TAP on Technology

 

Genetic Profiling in Non–Small Cell Lung Cancer

May 15, 2011, Volume 2, Issue 8

Approximately 2% to 7% of patients with non–small cell lung cancer (NSCLC) have tumors with oncogenic fusion genes consisting of portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene (EML4-ALK). In a study recently reported by K...

Lung Cancer Mutation Consortium Investigates Genetic Changes, Seeking to Reduce Associated Mortality

May 15, 2011, Volume 2, Issue 8

We have entered a new era in the management of patients with non–small cell lung cancer (NSCLC). To select the optimal therapy we must now distinguish between the histologic subtypes of NSCLC and we must know the genetic alterations in these cancers. Adequate biopsies are now required to ensure t...

Nanofluidic Proteomic Immunoassay for Measuring Oncoprotein Expression and Phosphorylation

May 1, 2011, Volume 2, Issue 7

Cancers are frequently associated with the abnormal expression and phosphorylation of oncogenes, and the ability to detect specific oncoproteins and their activated forms is a major goal in efforts to develop new treatments and methods for assessing response to treatments. Current methods for pro...

Robot-assisted Laparoscopic Radical Prostatectomy: Risks and Benefits

November 2010, Volume 1, Issue 6

With robot-assisted laparoscopic radical prostatectomy (LRP), the prostate gland can be removed via several 1- to 2-inch incisions in the patient's abdomen. The procedure involves use of a robotic system consisting of a device that holds surgical instruments and a laparoscopic camera (Fig. 1); t...

Multiparameter Gene Profile Assays for Predicting Recurrence of Colon Cancer

September 2010, Volume 1, Issue 4

This year saw the introduction of the first commercially available multiparameter gene profile assay for predicting risk of recurrence of colon cancer after surgery. The Oncotype DX colon cancer assay (Genomic Health) for predicting risk of recurrence in patients with stage II disease was l...

Multiparameter Breast Cancer Gene Profiling Assays

July 2010, Volume 1, Issue 2

Gene expression profiling is a technology for identifying genes potentially associated with disease prognosis and response to therapies. The technology identifies and quantifies cellular messenger RNA (mRNA), thus providing information on the global activity of genes producing the mRNA transcrip...

Proteomics, Cancer, and the Future of Tailored Therapy

June 2010, Volume 1, Issue 1

Proteomics is the study of the identity, properties, and functions of proteins. A proteome is the total set of proteins in a cell or organism, for example, just as a genome is the total set of genes in a cell or organism. Proteomics is more complicated than its sister science of genomics for a nu...

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