Heinz-Josef Lenz, MD
Heinz-Josef Lenz, MD, of the University of Southern California in Los Angeles, said the results of the ONO-4538 trial were impressive in light of this challenging patient population. “You see a significant benefit in a highly refractory gastric cancer population,” he said.
Dr. Lenz cautioned: “Don’t get stuck on the median, because the median did not give the full benefit. You see a continuous separation of the survival curves, and as you know, the hazard ratio is the combined differences of both curves over the whole course of survival—the cumulative effect.”
Future studies should focus on identifying subgroups of patients whose response to nivolumab drove the overall results of ONO-4538, Dr. Lenz said. ■
Disclosure: Dr. Lenz reported no potential conflicts of interest.
These results indicate that nivolumab could be a new treatment option for patients with heavily pretreated advanced gastric cancer and also provide a strong rationale to explore nivolumab in earlier lines of treatment.— Yoon-Koo Kang, MD
Gastric cancer can...!-->!-->