Expert Point of View: Lloyd Damon, MD


Get Permission

Lloyd Damon, MD

Lloyd Damon, MD, Professor of Medicine at the University of California, San Francisco, discussed the study and noted that although ruxolitinib (Jakafi) is associated with a fair amount of anemia and thrombocytopenia, pacritinib did not increase these conditions in PERSIST-1. In fact, treatment was associated with a reduction in the need for transfusions. The lack of such toxicity allows pacritinib to be given to patients with low platelet counts, for whom ruxolitinib is not indicated or is used at a lower and possibly less effective dose.

For these reasons, he said, “Pacritinib is a very important agent for patients with advanced disease.” ■

Disclosure: Dr. Damon reported no potential conflicts of interest.

 


Related Articles

Pacritinib for Myelofibrosis: Effective in Patients With Thrombocytopenia

An emerging JAK inhibitor, pacritinib, appears not only effective in a broad population of patients with myelofibrosis but also among a subset with very low platelet counts, investigators from the global phase III PERSIST-1 trial reported at the 2015 ASCO Annual Meeting.1

“There is a huge unmet...

Advertisement

Advertisement



;
Advertisement

By continuing to browse this site you permit us and our partners to place identification cookies on your browser and agree to our use of cookies to identify you for marketing. Read our Privacy Policy to learn more.