“The clinical question addressed by the guideline is: What are the optimum prevention and treatment approaches in the management of chemotherapy-induced neuropathies in adult cancer survivors?”
ASCO has released a clinical practice guideline on prevention and treatment of chemotherapy-induced peripheral neuropathy in adult cancer patients, published in the Journal of Clinical Oncology.1
The guidelines resulted from the efforts of an expert panel, with representation from the fields of medical oncology, community oncology, nursing, pain research, genetics, neurology, pharmacology, patient representation, and guideline methodology. Charles Loprinzi, MD, of the Mayo Clinic, Rochester, Minnesota, and Dawn Hershman, MD, of Columbia University Medical Center, New York, were the panel co-chairs.
The overall incidence of the condition is estimated at close to 40% in patients treated with multiple agents, with reported rates varying according to chemotherapy regimens, duration of exposure, and assessment methods. Regimens associated with higher risk are those including platinum drugs, vinca alkaloids, bortezomib (Velcade), and taxanes.
The clinical question addressed by the guideline is: What are the optimum prevention and treatment approaches in the management of chemotherapy-induced neuropathies in adult cancer survivors? Guideline development involved a systematic literature search to identify randomized controlled trials in management of chemotherapy-induced peripheral neuropathy. The search identified 1,252 potentially relevant citations, of which 250 were examined in detail, with 48 trials meeting eligibility criteria for use as the evidentiary basis for guideline recommendations. The trials were reported between 1990 and 2013.
A total of 42 studies provided information on 19 different interventions for the prevention of chemotherapy-induced peripheral neuropathy; 6 studies provided information on 6 different agents evaluated in treatment of established neuropathy. The outcomes of interest in analysis of evidence were the incidence and severity of neuropathy, neurophysiologic measures, patient-reported outcomes, and quality of life. The trials generally were small and heterogeneous, often with sample sizes not sufficiently large to detect clinically important differences in outcomes, and usually were not directly comparable due to use of different outcomes and measurements.
Due to lack of high-quality, consistent evidence, the guidelines do not recommend any agents for use in prevention of chemotherapy-induced peripheral neuropathy. The guidelines specify that clinicians should not offer the following agents for prevention of peripheral neuropathy in cancer patients undergoing treatment with neurotoxic agents:
The guidelines provide a moderate strength recommendation for treatment of chemotherapy-induced peripheral neuropathy with duloxetine (intermediate strength of evidence, moderate evidence of efficacy, and low evidence of harm).
No recommendations (recommendation = inconclusive) could be made on the use of the following agents, although the guidelines consider it reasonable to try tricyclic antidepressants, gabapentin, and a topical gel treatment containing baclofen, amitriptyline, and ketamine in select patients:
For tricyclic antidepressants, gabapentin, and the compounded topical gel, use should occur after discussion with patients about the limited evidence of efficacy in chemotherapy-induced peripheral neuropathy, potential harms and benefits, cost, and patient preferences. The guidelines state that further research on use of these agents in chemotherapy-induced peripheral neuropathy is warranted.
The guidelines make a moderate recommendation against use of lamotrigine (intermediate strength of evidence, no evidence of efficacy, low evidence of harm) in treatment of chemotherapy-induced peripheral neuropathy. ■
Disclosure: For full disclosures of the authors, visit jco.ascopubs.org.
1. Hershman DL, Lacchetti C, Dworkin RH, et al: Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol. April 17, 2014 (early release online).
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