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issues in oncology

Representation of Minorities and Women in Oncology Clinical Trials From 2003 to 2016

In a study reported in the Journal of Oncology Practice, Duma et al found that African American, Hispanic, older, and female patients were underrepresented in oncology clinical trials during the period of 2003 to 2016. Study Details The study involved analysis of enrollment data from all cancer...

issues in oncology

Survival as Quality Metric in Cancer Care

In a National Cancer Data Base study reported in the Journal of Oncology Practice, Shulman et al found little difference in risk-adjusted cancer mortality rates among individual hospitals, suggesting survival may not be an ideal quality metric at the individual hospital level. However, survival was ...

issues in oncology

Worldwide Cancer Incidence and Mortality Among Persons Aged 20 to 39 in 2012

In a study reported in The Lancet Oncology, Fidler et al found that cancer burden was higher worldwide among women vs men aged 20 to 39 in 2012 and that the incidence was higher but mortality lower in very high vs low Human Development Index regions. Study Details The study involved data from the ...

issues in oncology

Changes in Uninsured Status Among Nonelderly Cancer Patients Under the Affordable Care Act

In a research letter in JAMA Oncology, Soni et al reported reductions in the proportion of nonelderly adult cancer patients who were uninsured between 2010 and 2013 vs 2014, after institution of the Affordable Care Act (ACA). Study Details The study used data from the Surveillance, Epidemiology,...

issues in oncology

Racial/Ethnic Disparities in Cancer-Specific Survival in California

In a study using California Cancer Registry data reported in the Journal of Clinical Oncology, Ellis et al found that the stage at diagnosis was the greatest contributor to racial/ethnic disparities in cancer-specific survival, with neighborhood socioeconomic status and marital status also being...

issues in oncology

Changes in Insurance Coverage and Diagnosis Stage After Affordable Care Act Implementation

Jemal et al found decreases in the percentage of uninsured patients and trends toward earlier diagnosis among nonelderly patients with cancer after implementation of the Affordable Care Act (ACA). Their findings were reported in the Journal of Clinical Oncology. Study Details The study used...

issues in oncology

Psychological Outcomes in Adolescents With a Parent Dying of Cancer

In a study in the Swedish population reported by Beernaert et al in the Journal of Clinical Oncology, distrust in the end-of-life care provided to a parent with cancer was associated with long-term adverse emotional/psychological effects among bereaved adolescents. Study Details The study...

issues in oncology

Survival After In-Hospital Cardiac Arrest in Patients With Advanced Cancer

In a study reported in the Journal of Oncology Practice, Bruckel et al found that among patients with in-hospital cardiac arrest, those with advanced cancer had lower survival rates and were more frequently designated Do Not Attempt Resuscitation (DNAR) within 48 hours after return of spontaneous...

issues in oncology

Factors in Discontinuation of Palliative Radiotherapy

In a study reported by Puckett et al in the Journal of Oncology Practice, factors associated with premature discontinuation of palliative radiotherapy in cancer patients included poorer performance status, higher number of prescribed radiotherapy fractions, and treatment site other than bone...

issues in oncology

Guideline-Based Statin Eligibility and Cancer Risk

A study in the offspring and third-generation cohorts of the Framingham Heart Study showed that eligibility for statin therapy was associated with an increased risk for cancer and cancer mortality. These findings were reported by Pursnani et al in the Journal of Clinical Oncology. Study Details...

issues in oncology

New Model for Estimating Glomerular Filtration Rate and Accurately Dosing Carboplatin in Cancer Patients

Janowitz et al have developed a new model for estimating glomerular filtration rate (GFR) that improves accuracy compared with chromium-51 (51Cr) EDTA excretion measurements and accuracy of carboplatin dosing compared with other published models in cancer patients. Their findings were reported in...

issues in oncology

Understanding of Stage and Cancer Status Among Patients in a Community-Based Cancer Institute

As reported by Sivendran et al in the Journal of Oncology Practice, half of patients in a large community-based cancer institute did not know their stage of cancer, and one-third did not know of their cancer-free/in-remission status. Study Details The study involved 208 adult patients treated at...

issues in oncology

Factors Associated With Near-Miss/Safety Incidents in Cancer Radiotherapy

In a single-institution case-control analysis reported in the Journal of Oncology Practice, Judy et al found that complexity of procedure or schedule was a significant factor in near-miss or safety incidents involving cancer patients undergoing radiotherapy. Study Details The study involved a...

issues in oncology

Twitter Use at the ASCO Annual Meeting

As reported by Pemmaraju et al in the Journal of Oncology Practice, use of Twitter at the ASCO Annual Meeting has increased dramatically between 2011 and 2016. The investigators conducted a retrospective review of publicly available tweets collected by Nephrology On-Demand Analytics for the ASCO...

issues in oncology

Predictors of Adherence to Oral Chemotherapy

In a single-center study reported in the Journal of Oncology Practice, Jacobs et al found that improved satisfaction with clinician communication and treatment was the strongest predictor of treatment adherence in patients receiving oral anticancer medication. Study Details The prospective study...

issues in oncology

ASCO Research Statement: Tapping the Potential of Observational Research

In a research statement reported in the Journal of Clinical Oncology by Visvanathan et al, ASCO has outlined steps for incorporating high-quality observational research into the evidence base for clinical decision-making. As stated by the authors: “ASCO believes that high-quality...

issues in oncology

Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Postmenopausal Women

In a population-based trial reported in JAMA, Lappe et al found that dietary supplementation with vitamin D3 and calcium did not significantly reduce the incidence of all cancers over 4 years among postmenopausal women aged ≥ 55 years. Study Details In the double-blind trial, 2,303 healthy...

issues in oncology

Factors Associated With Early Death in Childhood Cancer

In a study reported in the Journal of Clinical Oncology, Green et al found that risk factors for death within 1 month of diagnosis of childhood cancer included age up to 1 year, specific diagnoses, and minority race/ethnicity. The study involved analysis of data from SEER (Surveillance,...

issues in oncology

Trends in Cancer Mortality in the United States and U.S. Counties From 1980 to 2014

In a study reported in JAMA, Mokdad et al found that cancer mortality rates have dropped from 240.2 to 192.0/100,000 population between 1980 and 2014. Mortality rates varied widely among U.S. counties for various cancers. The report covers 29 cancers in 3,144 counties. Summarized here are findings...

issues in oncology

Predicting Outcomes in Older Patients With Cancer

In the French ELCAPA14 study reported in the Journal of Clinical Oncology, Ferrat et al found that four frailty classifications performed well in predicting outcomes in a cohort of patients aged ≥ 70 years with various cancers. Study Details The study involved 763 in- or outpatients with...

issues in oncology

Potential Biomarker of Recurrent Venous Thromboembolism in Cancer Patients Receiving Anticoagulant Therapy

In a biomarker analysis of the CATCH trial reported in the Journal of Clinical Oncology, Khorana et al found that elevated circulating tissue factor levels were associated with an increased risk of recurrent venous thromboembolism in cancer patients on anticoagulant therapy. CATCH was a randomized ...

solid tumors
issues in oncology

Genome-Based Model for Adjusting Radiotherapy Dose Shows Promise

In a retrospective cohort–based study reported in The Lancet Oncology, Scott et al found that individual patient genomic-adjusted radiation dose was associated with outcomes across different cancer types. Study Details In the study, gene-expression–based radiation-sensitivity index...

issues in oncology

Customer Response to Personal Genomic Testing for Cancer Risk

In a study reported in the Journal of Clinical Oncology, Gray et al found that most people receiving cancer-related data through direct-to-consumer personal genomic testing tended not to change health or screening behaviors when an elevated risk was identified. The study involved baseline and...

issues in oncology

Concerns About Safety of Generic Oncology Drugs Made in Developing Countries

In a Lancet Oncology article, Yang et al examined clinical, policy, safety, and regulatory considerations for generic oncology drugs focusing on the United States, Canada, European Union (EU), Japan, China, and India. Available data do not identify safety concerns in the United States, Canada, EU,...

prostate cancer
issues in oncology

Study Reports No Association Between Vasectomy and Prostate Cancer Incidence or Mortality

In an analysis of the Cancer Prevention Study II (CPS-II) study cohort reported in the Journal of Clinical Oncology, Jacobs et al found no significant association between vasectomy and overall prostate cancer incidence or mortality. A recent prospective study had shown an association of vasectomy...

issues in oncology

Decisional Regret After Initial Treatment Decisions Among Parents of Children With Cancer

Racial/ethnic minority parents were more likely to express regret about initial cancer treatment decisions for their children, according to a study reported in the Journal of Clinical Oncology. Mack et al found that factors associated with less decisional regret included receiving high-quality...

issues in oncology

ASCO and AACI Collaborate on Initiative to Reduce Administrative and Regulatory Burden in Cancer Clinical Trials

As reported in the Journal of Clinical Oncology, Vose et al have provided a summary of the groundwork of an initiative by ASCO and the Association of American Cancer Institutes (AACI) to identify and reduce administrative and regulatory burdens in the conduct of cancer clinical trials. The...

breast cancer
issues in oncology

Potential Link Between Obesity and Cardiotoxicity From Anthracyclines Alone or With Trastuzumab for Breast Cancer

Obesity and being overweight were associated with an increased risk of cardiotoxicity in women receiving treatment with anthracyclines and sequential anthracyclines/trastuzumab (Herceptin) for breast cancer, according to a systematic review and meta-analysis reported in the Journal of Clinical...

solid tumors
issues in oncology

Increased Obesity Rates Reported in Adults With a History of Cancer

In a population-based study reported in the Journal of Clinical Oncology, Greenlee et al found that rates of obesity have increased more in patients with a history of cancer than in the general population. These rates were particularly high among survivors of colorectal and breast cancers and black ...

palliative care
issues in oncology

Hematologic Oncologists Surveyed on Quality Measures of End-of-Life Care and Barriers to Such Care

In a study reported in the Journal of Clinical Oncology, Odejide et al surveyed hematologic oncologists to identify acceptable end-of-life-care quality measures and asked the clinician to identify barriers to such care. Respondents considered unrealistic patient expectations the top barrier to...

issues in oncology

Lifestyle Pattern May Be Associated With Cancer Risk in White Adults

In a study reported in JAMA Oncology, Song and Giovannucci found that a “healthy lifestyle pattern” was associated with a reduced risk for carcinomas among white adults. Study Details The study included data from the Nurses’ Health Study and the Health Professionals Follow-up...

lymphoma
issues in oncology

European Study Suggests No Benefit of GnRH in Preserving Ovarian Function and Fertility in Young Women With Lymphoma

In long-term follow-up of a European trial reported by Demeestere et al in the Journal of Clinical Oncology, gonadotropin-releasing hormone (GnRH) agonist treatment during chemotherapy in young women with lymphoma was not associated with reduced premature ovarian failure or an improved pregnancy...

issues in oncology

Study Finds Poor Understanding of Illness in Patients With Advanced Cancer

Few patients with advanced cancer and a short life expectancy have an accurate understanding of their illness, according to a study reported in the Journal of Clinical Oncology by Epstein et al. Study Details The study involved 178 patients from 9 U.S. cancer centers who had advanced cancers...

issues in oncology
cost of care

Global Economic Crisis May Be Linked to Increased Cancer Mortality

The global economic crisis has been associated with increased unemployment and reduced public-sector expenditure on health care. In a study reported in The Lancet, Maruthappu et al found that the global economic crisis beginning in 2008 was also associated with a large excess in cancer mortality...

hematologic malignancies
issues in oncology

Four-Biomarker Panel Identified for Chronic Graft-vs-Host Disease

In a study reported in the Journal of Clinical Oncology, Yu et al identified a four-biomarker panel that was predictive of chronic graft-vs-host disease after allogeneic hematopoietic cell transplantation. Discovery Cohort In the study, a quantitative proteomics approach was used to compare...

issues in oncology

Leisure-Time Physical Activity Reduces Risk of Multiple Cancer Types

In a study reported in JAMA Internal Medicine, Moore et al found that greater leisure-time physical activity was associated with a reduced risk for many types of cancer. Study Details The study used pooled data on 1.44 million adults from 12 prospective U.S. and European cohorts with...

breast cancer
solid tumors
issues in oncology

Racial Disparities in Early Supportive Medication Use and End-of-Life Care Among Medicare Patients With Stage IV Breast Cancer

In a study reported in the Journal of Clinical Oncology, Check et al identified disparities in supportive medication use and end-of-life care between black and white Medicare patients with stage IV breast cancer. Study Details The study involved SEER (Surveillance, Epidemiology, and End...

gynecologic cancers
issues in oncology

ASCO Statement on Human Papillomavirus Vaccination for Cancer Prevention

As reported in the Journal of Clinical Oncology by Bailey et al, ASCO has released a statement on increasing human papillomavirus (HPV) vaccination to prevent HPV-related cancers in the United States. In the United States, HPV is estimated to cause approximately 99.7% of cervical cancers, 60% of...

solid tumors
hematologic malignancies
issues in oncology
survivorship

Increased Risk of Cardiovascular Disease Among Survivors of Some Adult-Onset Cancers

In a study using managed-care organization data reported in the Journal of Clinical Oncology, Armenian et al found that survivors of adult-onset multiple myeloma, non-Hodgkin lymphoma, lung/bronchus cancer, and breast cancer had an increased risk for subsequent cardiovascular disease. Study...

issues in oncology

Families of Cancer Decedents See Early Hospice, ICU Avoidance, and Death Outside the Hospital as Better End-of-Life Care

Families of patients dying with lung or colorectal cancer judged end-of-life care as better when it was less aggressive, involved earlier hospice, avoided intensive care unit (ICU) admission, and included death outside of the hospital, according to a study reported by Wright et al in JAMA. Study...

palliative care
issues in oncology
global cancer care

Site of Death, Health-Care Utilization, and Hospital Expenditures for Patients Dying With Cancer in Developed Countries

In a study reported in JAMA, Bekelman et al assessed the site of death, health-care utilization, and hospital expenditures among patients aged ≥ 65 years dying with cancer in Belgium, Canada, England, Germany, the Netherlands, Norway, and the United States. The United States had lower...

breast cancer
issues in oncology

ASCO Clinical Practice Guideline Update on Ovarian Suppression/Adjuvant Endocrine Therapy in Hormone Receptor–Positive Breast Cancer

As reported in the Journal of Clinical Oncology by Burstein et al, ASCO has released a clinical practice guideline update on ovarian suppression as part of the extant guideline on adjuvant endocrine therapy in hormone receptor–positive breast cancer. The update is based on an update panel...

survivorship
cns cancers
issues in oncology

Increased Risk of Severe Neurocognitive Impairment in Adult Survivors of Pediatric CNS Tumors

As reported in the Journal of Clinical Oncology by Brinkman et al, a study in the St. Jude Lifetime Cohort showed that adult survivors of pediatric central nervous system (CNS) tumors are at increased risk of severe neurocognitive impairment. Study Details The study involved 224 survivors of CNS...

supportive care
issues in oncology

UK Trial Shows Little Benefit of Pregabalin Combined With Palliative Radiotherapy for Cancer-Induced Bone Pain

In a UK study reported in the Journal of Clinical Oncology, Fallon et al found no improvement with pregabalin vs placebo combined with concurrent palliative radiotherapy in relieving cancer-induced bone pain. Study Details In the double-blind trial, 233 patients with bone metastases who were...

issues in oncology

Higher Risk of Cancer Mortality in Solid-Organ Transplant Recipients

In a study reported in JAMA Oncology, Acuna et al found a nearly threefold increased risk of cancer mortality in solid-organ transplant recipients compared with the general population in Ontario, Canada. Study Details The population-based cohort study included data from 11,061 patients who...

survivorship
issues in oncology

Material and Psychological Financial Hardship for U.S. Cancer Patients

In a population-based study reported in the Journal of Clinical Oncology, Yabroff et al found that cancer and its treatment were associated with material financial hardship for 29% and psychological financial hardship for 32% of patients aged 18 to 64 years in the United States. Financial hardship...

breast cancer
issues in oncology

UK Study Suggests Association Between Screen-Detected Ductal Carcinoma in Situ and Reduced Invasive Interval Breast Cancers

In a UK retrospective population-based study reported in The Lancet Oncology, Duffy et al found a significant inverse association between the detection of ductal carcinoma in situ in breast cancer screening and the incidence of invasive interval cancers diagnosed within 3 years after screening....

gynecologic cancers
issues in oncology

UK Study Suggests Potential Mortality Benefit of Ovarian Cancer Screening in Postmenopausal Women

As reported in The Lancet by Jacobs et al, the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) suggests there may be a mortality benefit of ovarian cancer screening in postmenopausal women. Study Details In the trial, 202,546 postmenopausal women aged 50 to 74 years from 13 centers...

solid tumors
issues in oncology

Increased Risk of Carcinoma of Unknown Primary and Other Cancers in Relatives of Patients With This Type of Cancer

In a study from the Utah Cancer Registry reported in JAMA Oncology, Samadder et al found an increased risk of carcinoma of unknown primary and other cancers in relatives of patients with this type of cancer. Study Details The study was a nested case-control study including 4,160 patients with a...

gynecologic cancers
gynecologic cancers
issues in oncology

Study Shows ACA Coverage Expansion Resulted in Increased Cervical Cancer Diagnosis at Early Stage in Young Women

In a study reported in a research letter in JAMA, Robbins et al found evidence that the Affordable Care Act Dependent Coverage Expansion (ACA-DCE) has resulted in increased diagnosis of cervical cancer at an early stage and increased use of fertility-sparing treatments in women aged 21 to 25 years. ...

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