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SABCS 2014: High Tumor Immune Cell Levels May Identify HER2-Positive Breast Cancer Patients Who Might Benefit From Chemotherapy Alone

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Key Points

  • Patients with high levels of tumor-infiltrating lymphocytes had an 80% decreased chance of disease recurrence after a median follow-up of 4.4 years.
  • The level of tumor-infiltrating lymphocytes had no impact on the benefit of adding trastuzumab to chemotherapy.

Women with HER2-positive breast cancer who had high levels of immune cells in their tumors had a decreased risk of cancer recurrence after treatment with chemotherapy alone compared with their counterparts who had low levels of tumor-infiltrating immune cells, according to data presented at the 2014 San Antonio Breast Cancer Symposium (Abstract S1-06). There was no association between tumor-infiltrating immune cell levels and recurrence-free survival among women who received chemotherapy and the HER2-targeted therapy trastuzumab (Herceptin).

“There are two main findings from our study,” said Edith A. Perez, MD, Deputy Director at large for the Mayo Clinic Cancer Center and the Serene M. and Frances C. Durling Professor at Mayo Clinic College of Medicine, based in Jacksonville, Florida. “First, patients with high levels of tumor-infiltrating immune cells did well with chemotherapy alone. Second, the level of tumor-infiltrating immune cells had no impact on the benefit of adding trastuzumab to chemotherapy.”

Phase III Trial

Among 489 women with early-stage, HER2-positive breast cancer who were randomly assigned in the phase III clinical trial N9831 to chemotherapy alone, those with high levels of tumor-infiltrating immune cells had an 80% decreased chance of disease recurrence after a median follow-up of 4.4 years. Among the 456 patients randomly assigned to chemotherapy and trastuzumab, the chance of disease recurrence was the same irrespective of the levels of tumor-infiltrating immune cells.

“We have previously reported that adding trastuzumab to chemotherapy significantly improved recurrence-free and overall survival in N9831,” said Dr. Perez. “However, not all patients benefited from addition of trastuzumab, and some did well with chemotherapy alone. These results suggest that levels of tumor-infiltrating immune cells may provide a biomarker to identify patients who might do well without trastuzumab, but we must conduct additional large clinical trials before we can consider changing clinical practice and omitting HER2-targeted therapy from the treatment regimens for patients who have high levels of tumor-infiltrating immune cells.

Next Steps

“We were somewhat surprised by our finding that high levels of tumor-infiltrating immune cells were not associated with increased benefit among women receiving trastuzumab because a previous study had shown that this was the case,” continued Dr. Perez. “However, the previous study had many fewer cases and lower statistical power.”

The investigators analyzed primary tumor samples obtained prior to patients initiating chemotherapy or chemotherapy and trastuzumab treatment. Samples were considered to have high levels of tumor-infiltrating immune cells if 60% or more of cells in the sample section being analyzed were immune cells.

In future analysis, Dr. Perez and her colleagues will look at the different subtypes of immune cells and determine if any subtype in particular is associated with improved patient outcomes.

This study was supported by funds from the 26.2 With Donna Foundation and the Breast Cancer Research Foundation. Dr. Perez reported no potential conflicts of interest

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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