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GU Symposium 2016: Regular Aspirin Use May Reduce Risk of Dying From Prostate Cancer

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Key Points

  • After adjusting for differences in age, race, body mass index, and smoking status, men without a diagnosis of prostate cancer who took aspirin regularly (more than three tablets a week) had a 24% lower risk of developing lethal prostate cancer.
  • Aspirin did not affect the likelihood of being diagnosed with prostate cancer in general and high-grade prostate cancer or locally advanced prostate cancer in particular.
  • Among men with prostate cancer, regular aspirin use after diagnosis was associated with a 39% lower risk of dying from prostate cancer. In contrast, use of aspirin before diagnosis did not have a measurable benefit.

A large observational study has found that men who take aspirin regularly may have a lower risk of dying from prostate cancer. Men who took aspirin regularly after their prostate cancer diagnosis were less likely to die from the disease. However, aspirin did not affect the overall incidence of prostate cancer. The study was presented by Allard et al at the 2016 Genitourinary Cancers Symposium in San Francisco (Abstract 306).

“It is premature to recommend aspirin for prevention of lethal prostate cancer, but men with prostate cancer who may already benefit from aspirin’s cardiovascular effects could have one more reason to consider regular aspirin use,” said lead study author Christopher Brian Allard, MD, Urologic Oncology Fellow at Brigham and Women's Hospital and Massachusetts General Hospital. “When discussing potential benefits of aspirin with their doctors, in terms of both cardiovascular health and risk of prostate cancer death, men should also consider potential risks of regular aspirin use.”

Many studies have looked at medications and supplements that help reduce the risk of death from prostate cancer among healthy men or prolong survival of men with prostate cancer. Prior studies on aspirin and prostate cancer prevention have reported conflicting findings. According to the authors, this is the first study to specifically focus on prevention of lethal cancer, clarifying the role aspirin may play in prevention of advanced disease. 

Study Findings

The researchers analyzed data from 22,071 men enrolled in the Physicians’ Health Study. Over 27 years of follow-up, 3,193 men were diagnosed with prostate cancer. Of those, 403 men developed lethal prostate cancer, defined as metastatic disease or death from prostate cancer.

After adjusting for differences in age, race, body mass index, and smoking status, men without a diagnosis of prostate cancer who took aspirin regularly (more than three tablets a week) had a 24% lower risk of developing lethal prostate cancer. However, aspirin did not affect the likelihood of being diagnosed with prostate cancer in general and high-grade prostate cancer or locally advanced prostate cancer in particular.

Among men with prostate cancer, regular aspirin use after diagnosis was associated with a 39% lower risk of dying from prostate cancer. In contrast, use of aspirin before diagnosis did not have a measurable benefit.

“We think that aspirin probably prevents progression of prostate cancer to metastases,” said Dr. Allard. While the biologic basis for this protective effect is unknown, preclinical research suggests aspirin may prevent the spread of cancer to the bone.

Dr. Allard and his research team will continue to explore the ways aspirin decreases risk of prostate cancer death. Meanwhile, more research is needed to determine which men in particular would benefit from regular aspirin and what the optimal dose of aspirin is.

This study received funding from the Prostate Cancer Foundation and the National Institutes of Health/National Cancer Institute.

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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