Everolimus and fulvestrant is another standard-of-care option, and with the evidence from this trial, I won’t have to fight insurance companies for reimbursement.— Virginia Kaklamani, MD
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How can the results of this trial be applied to clinical practice? Press conference moderator, Virginia Kaklamani, MD, of the University of Texas Health Science Center in San Antonio, said: “The landscape has changed. Now we treat postmenopausal hormone receptor–positive, HER2-negative metastatic breast cancer with letrozole and palbociclib [Ibrance] first line. What do we do for second-line therapy? We would not use another aromatase inhibitor. We could use fulvestrant [Faslodex] or exemestane plus everolimus [Afinitor].”
“This study suggests that everolimus and fulvestrant is a new option for second-line therapy. It is another standard-of-care option, and with the evidence from this trial, I won’t have to fight insurance companies for reimbursement,” Dr. Kaklamani said. ■
Disclosure: Dr. Kaklamani reported no potential conflicts of interest.
The addition of everolimus (Afinitor) to fulvestrant (Faslodex) doubled progression-free survival in postmenopausal women with hormone receptor–positive, HER2-negative metastatic breast cancer resistant to aromatase inhibitor therapy compared with fulvestrant plus placebo, according to the...