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Your search for Jo Cavallo matches 82 pages

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breast cancer

Chemotherapy Plus Targeted Therapy Reduces Recurrence in Women With Early-Stage HER2-Positive Breast Cancer

A phase II clinical study of adjuvant paclitaxel and trastuzumab (Herceptin) in women with stage I HER2-positive breast cancer has found the 3-year rate of survival free from invasive disease was 98.7%. The findings may help establish the combination therapy as the first standard treatment approach ...

breast cancer

DNA Vaccine Targeting Mammaglobin-A Produces Robust Immune Response in Metastatic Breast Cancer

In a phase I study, a DNA vaccine targeting the breast cancer–associated antigen mammaglobin-A (MAM-A) was found to be safe and effective in eliciting immune responses in women with metastatic breast cancer. Preliminary evidence also suggests that the vaccine improved progression-free...

breast cancer

Study Finds No Link Between Wearing a Bra and Breast Cancer

Despite conjecture in the lay media that wearing a bra may be a risk factor for breast cancer based on the potential for bras to interfere with lymph circulation and drainage, hampering the removal of waste and toxins, there were few scientific studies investigating the issue. Now, a new study by...

breast cancer

Study Finds Significant Increase in Bilateral Mastectomies Despite Lack of Survival Benefit

Results from a large population-based study of 189,734 women diagnosed with early-stage breast cancer in California show the percentage opting for a bilateral mastectomy has increased substantially over the past decade even though the procedure was not associated with a lower risk of death than...

breast cancer
issues in oncology

Danish Study Finds an Increased Risk of Developing Breast Cancer in Women With Previous False-Positive Mammography

Although studies have shown that women with a false-positive result from mammography screening have an increased risk of developing breast cancer later in life compared with women who only have negative results, a new Danish study examined how much of the excess risk was due to misclassification...

breast cancer

NSAID Use May Reduce Risk of Breast Cancer Recurrence in Overweight and Obese Women

Obesity is associated with a worse breast cancer prognosis and elevated levels of inflammation, including greater cyclooxygenase-2 (COX-2) expression and activity in adipose-infiltrating macrophages. Data from a new study finds that overweight and obese women who regularly used aspirin or other...

breast cancer
issues in oncology

Regular, Moderate Physical Activity Decreases Breast Cancer Risk in Postmenopausal Women

Postmenopausal women who in the previous 4 years had undertaken the equivalent of at least 4 hours of walking per week had a 10% decreased risk of invasive breast cancer compared with women who were less active, according to a new study. The findings suggest that regular physical activity, even of...

issues in oncology
breast cancer
issues in oncology

Gene Signature May Predict Which Breast Cancer Patients Will Benefit From Tamoxifen

A novel approach using ChIP-seq and RNA-seq analysis in combination with RNA expression data has identified a gene called USP9X that may predict which patients with estrogen receptor–positive breast cancer will benefit from tamoxifen therapy after surgery. The gene signature the researchers...

breast cancer

Study Compares Tamoxifen Gel Applied to the Breast With Oral Tamoxifen in Women With DCIS

A randomized, double-blind, placebo-controlled phase II trial comparing the antiproliferative effect of transdermal 4-hydroxytamoxifen gel (4-OHT), a potent antiestrogenic metabolite of tamoxifen, applied to the breast and oral tamoxifen in women with ductal carcinoma in situ (DCIS), has found the...

breast cancer

Combining Multiple Imaging Approaches Can Better Distinguish Malignant and Benign Breast Tumors and Reduce Unnecessary Biopsies

A new study found that an imaging technique called multiparametric 18fluorodeoxyglucose positron-emission tomography magnetic resonance imaging (18FDG PET-MRI), which combines four imaging approaches, can better distinguish malignant breast tumors from those that are benign, compared with imaging...

issues in oncology
breast cancer

Novel Blood-Based Biomarkers May Predict Breast Cancer Recurrence and Treatment Response

Researchers have developed a quantitative multiplexed methylation-specific polymerase chain reaction assay called cMethDNA for a panel of 10 breast cancer–specific genes. The blood-based assay was found to be highly sensitive in detecting advanced breast cancer and monitoring tumor burden and ...

breast cancer

I-SPY 2 Results Identify Subset of Breast Cancer Patients Most Likely to Benefit From Neratinib

Findings from the I-SPY 2 randomized phase II clinical trial for women with newly diagnosed stage II breast cancer show that a neoadjuvant regimen containing the investigational drug neratinib, a pan-HER inhibitor, and standard chemotherapy is beneficial for patients with hormone...

breast cancer

Long-Term Study Finds Fertility Drugs Do Not Increase Breast Cancer Risk

A large study of over 12,000 women who took clomiphene citrate or gonadotropins for the treatment of infertility has found no increase in breast cancer risk over 30 years of follow-up, compared with women who were not treated with these medications. The study by Brinton et al is published in Cancer ...

breast cancer

ASCO Issues Updated Recommendations for Sentinel Lymph Node Biopsy in Early-Stage Breast Cancer

A review by ASCO’s Update Committee of new data from randomized clinical trials has led to a change in recommendations for the use of sentinel lymph node biopsy in patients with early-stage breast cancer. The updated guideline will enable more women with early-stage breast cancer to avoid the ...

breast cancer

Patient-Centered Outcomes Research Institute Develops Prioritized Research Agenda for the Management of DCIS

There is currently a lack of reliable methods for distinguishing ductal carcinoma in situ (DCIS) that would never become symptomatic from DCIS that is likely to progress to life-threatening invasive cancer. Spurred by uncertainty about the optimal clinical management of DCIS, researchers have...

issues in oncology
breast cancer
bladder cancer
issues in oncology

Molecular Features of Invasive Bladder Cancer Resemble Those of Breast Cancer

Using whole-genome mRNA-expression profiling, researchers have identified three molecular subtypes of muscle-invasive bladder cancers that shared molecular features with basal and luminal breast cancers. The findings have important implications for prognostication, the future clinical development...

breast cancer
issues in oncology

Study Identifies Possible Genetic Markers in Breast Cancer Brain Metastases

Scientists from the Translational Genomics Research Institute (TGen) have uncovered the possible genetic origins of breast cancers that metastasize to the brain. The compendium of new genetic targets may be be used to identify potential methods of diagnosis and novel therapeutics for patients with...

breast cancer
issues in oncology

Following USPSTF Mammography Screening Guidelines Could Save Billions of Dollars and Result in More Women Screened

Although controversial, reducing mammography screening frequency from annually to biennially for women aged 50 to 74 could save the health-care system billions of dollars annually and screen 15% more women compared with the current practice, according to a cost analysis by O’Donoghue et al....

breast cancer

New Findings Contradict Current Understanding of How to Manage Breast Biopsy Abnormalities

A long-term follow-up study by Hartmann et al of patients with two types of breast tissue abnormalities—atypical ductal hyperplasia and atypical lobular hyperplasia—suggests that both abnormalities have the same potential to advance to breast cancer. The findings could help improve...

breast cancer

New Mathematical Model Helps Predict Tumor Evolution and Treatment Effectiveness

A study by Almendro et al analyzed breast cancer tumors before and after treatment for important characteristics, including chromosome copy number, the presence or absence of certain protein markers, and their proliferative capacity. The scientists then used the data to develop computational models ...

issues in oncology
breast cancer

Higher Levels of HSET Linked to More Aggressive Breast Cancers and Worse Outcomes in African American Women

Data from a study by Ritu Aneja, PhD, Associate Professor in the Department of Biology at Georgia State University in Atlanta, and colleagues indicate that overexpression of the protein HSET is a valuable prognostic biomarker in African American women with breast cancer, but not in Caucasian...

breast cancer
issues in oncology

New Mutation Found in the Estrogen Receptor May Cause Resistance to Breast Cancer Treatment

Most patients with estrogen receptor–positive metastatic breast cancer who initially respond to endocrine treatments will eventually develop resistance to the therapies. A study by Ido Wolf, MD, Head of the Oncology Department at the Tel Aviv Sourasky Medical Center in Israel, and colleagues...

breast cancer

Measuring Hormone Levels Could Improve Risk Assessment for Breast Cancer

The inclusion of multiple hormones—rather than just adding one or two individually—in breast cancer risk prediction models may improve prediction of the disease and could help better identify women who would benefit from chemoprevention, according to a study by Shelley S. Tworoger, PhD, ...

breast cancer

Long-Distance Travel for Cancer Care Is Linked to Later-Stage Breast Cancer Diagnosis

The longer a woman with breast cancer has to travel to reach a comprehensive cancer center, the more likely she is to have later-stage disease at diagnosis, and the more likely she is to have a mastectomy, according to study by medical student Krishan Jethwa and colleagues from the University of...

breast cancer

Increased Physical Activity and Walking Reduces Breast Cancer Risk

A large epidemiology study of postmenopausal women by researchers at the American Cancer Society (ACS) has found that women who participated in at least 1 hour of vigorous physical activity every day had a 25% lower risk of breast cancer, and those who walked for at least 7 hours per week had a 14% ...

breast cancer

Breast Cancer Rates Are Rising Among African American Women

Although, historically, white women aged 40 years and older have had the highest incidence rates of breast cancer, the rising rate of breast cancer among African American women—especially among women aged 50 to 59—is narrowing the gap, according to a study by American Cancer Society...

breast cancer
issues in oncology

USPSTF Issues Final Recommendation Statement on Medications for the Risk Reduction of Primary Breast Cancer in Women

The U.S. Preventive Services Task Force (USPSTF) released today its final recommendation statement on medications to reduce the risk of primary breast cancer in women. Clinicians are recommended to prescribe risk-reducing medications, such as tamoxifen or raloxifene, for women who are at increased...

breast cancer

Low Adherence to Tamoxifen Therapy Increases Risk of Breast Cancer Recurrence and Early Death

Colin McCowan, PhD, of the University of Glasgow, and colleagues analyzed the prescription records of 1,263 women with breast cancer between 1993 and 2000 to determine how often they took their prescription of adjuvant tamoxifen following surgery and for how long. Women who filled less than 80% of...

breast cancer
issues in oncology

Experts Discuss Challenges in Counseling Patients About Contralateral Prophylactic Mastectomy

Many factors play into why women diagnosed with breast cancer often choose overly aggressive treatment even when there is little evidence to show clinical benefit: the shock and fear of suddenly being confronted with a major health threat, the impression of having to make treatment decisions...

breast cancer

Study Shows Isoflavone Exposure Has Little Effect on Breast Cancer Risk or Recurrence

According to a review of studies examining the impact of isoflavones in soyfoods on breast cancer risk, clinical evidence indicates that exposure to isoflavones, which are classified as both phytoestrogens and selective estrogen receptor modulators, has little effect on the markers of breast cancer ...

breast cancer
health-care policy
legislation

Two Bills before Congress Aim to Fight Breast Cancer and End Disparities in Care

Members of Congress are considering two bills that could advance cures for breast cancer and provide better education for women grappling with decisions about their treatment options. Accelerating the End of Breast Cancer Act Accelerating the End of Breast Cancer Act of 2013 (S. 865/H.R. 1830)...

breast cancer

Radiation Raises Risk of Heart Disease in Women Treated for Breast Cancer

A population-based case control study of major coronary events in 2,168 women who underwent radiotherapy for breast cancer between 1958 and 2001 in Sweden and Denmark found a direct link between radiation dose and the occurrence of ischemic heart disease years later. Study Details The study,...

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