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Your search for Matthew Stenger matches 419 pages

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breast cancer
issues in oncology

Study Finds No Improvement in Diagnostic Accuracy of Digital Screening Mammography With Computer-Aided Detection

In a study reported in JAMA Internal Medicine, Lehman et al found no difference in the diagnostic accuracy of digital screening mammography with vs without computer-aided detection. Study Details The study assessed the accuracy of digital screening mammography interpreted with (n = 495,818) vs...

colorectal cancer
issues in oncology

Women’s Health Initiative Clinical Trial Suggests Endogenous Estrogens May Protect Against Colorectal Tumorigenesis in Postmenopausal Women

In a nested case-control study in the Women’s Health Initiative Clinical Trial, reported in Journal of the National Cancer Institute by Murphy et al, endogenous estrogen levels were inversely associated with and sex hormone–binding globulin (SHBG) levels were positively associated with...

issues in oncology
prostate cancer
issues in oncology

Decreased Prostate-Specific Antigen Screening and Rate of Diagnosis in Early-Stage Prostate Cancer

Recent data indicated that the rates of prostate-specific antigen (PSA) screening and diagnosis of early-stage prostate cancer have decreased since a 2012 U.S. Preventive Services Task Force (USPSTF) statement (released in October 2011) gave a grade D recommendation against PSA screening for all...

breast cancer
issues in oncology

Systematic Review Informing ACS Updated Guideline for Breast Cancer Screening in Women at Average Risk

Findings of a systematic review of the benefits and harms of breast cancer screening commissioned by the American Cancer Society (ACS) to inform its updated guideline on screening in average-risk women were reported in JAMA by Myers et al of the Duke Evidence Synthesis Group. Their findings were...

issues in oncology
kidney cancer

Molecular Characterization of Papillary Renal Cell Carcinoma Shows Differences Between Type 1 and 2 Tumors

Comprehensive molecular characterization of primary papillary renal cell carcinoma, reported in The New England Journal of Medicine by The Cancer Genome Atlas Research Network, showed that type 1 and 2 papillary renal cell carcinomas were distinct types of disease based on differences in genetic...

issues in oncology
breast cancer

Elevated C-Reactive Protein May Be Associated With Increased Breast Cancer Risk in Postmenopausal Women Not Using Hormone Therapy

In a study reported in the Journal of the National Cancer Institute, Gunter and colleagues found that increased levels of the inflammatory marker C-reactive protein (CRP) were associated with increased risk of breast cancer in postmenopausal women not using hormone therapy. No associations of...

prostate cancer
issues in oncology

Meta-Analysis Indicates Noninferiority of Overall Survival With Intermittent vs Continuous Androgen-Deprivation Therapy in Prostate Cancer

In a meta-analysis reported in JAMA Oncology, Magnan et al found that intermittent androgen-deprivation therapy was noninferior to continuous androgen-deprivation therapy with respect to overall survival in patients with prostate cancer. Study Details A literature review identified 22 articles...

issues in oncology
pancreatic cancer

Phase II Study Shows No Benefit of Adding Vismodegib to Gemcitabine in Metastatic Pancreatic Cancer

In a phase II study reported in the Journal of Clinical Oncology, Catenacci et al found no benefit of adding vismodegib (Erivedge) to gemcitabine in patients with metastatic pancreatic cancer. Sonic hedgehog (SHH), an activating ligand of the smoothened receptor (SMO) inhibited by vismodegib, has...

breast cancer
issues in oncology

Less Favorable Characteristics for Breast Cancer Diagnosed After Biennial vs Annual Screening in Premenopausal Women

In a study reported in JAMA Oncology, Miglioretti et al found that diagnosis of breast cancer after biennial vs annual mammography screening was associated with a higher risk of less favorable tumor prognostic characteristics among premenopausal women. They also noted a nonsignificantly higher risk ...

colorectal cancer
issues in oncology

10-Year Results of MOSAIC Trial Show Continued Survival Benefit of Adjuvant FOLFOX4 in Stage III Colon Cancer

Ten-year results of the MOSAIC trial, reported in the Journal of Clinical Oncology by André et al show a continued overall survival benefit with adjuvant FOLFOX4 (fluorouracil [5-FU] leucovorin plus oxaliplatin) vs 5-FU/leucovorin in patients with stage III colon cancer and in the entire...

lung cancer
issues in oncology

Reported Hospitalization Rate in Patients Receiving Systemic Therapy for Metastatic NSCLC Much Higher in Real-World vs Clinical Trial Setting

In a study reported in JAMA Oncology, Prince et al found that the hospitalization rate among patients receiving systemic therapy for metastatic non–small cell lung cancer (NSCLC) was much higher in observational studies vs clinical trials among studies reporting hospitalization rates. Study...

breast cancer
issues in oncology
issues in oncology

Most Women Undergoing BRCA Genetic Testing Do Not Receive Pretest Genetic Counseling

In the ABOUT study reported in JAMA Oncology, Armstrong et al found that the majority of BRCA-tested women in a commercially insured population responding to a questionnaire about their experience had not received genetic counseling from a genetics clinician prior to testing. The study was...

supportive care
issues in oncology

Dexamethasone Reduces Pain Flare After Palliative Radiotherapy for Bone Metastases

In a Canadian phase III trial reported in The Lancet Oncology, Chow et al found that prophylactic dexamethasone reduced the incidence of radiation-induced pain flare compared with placebo in patients receiving palliative radiotherapy for bone metastases. Study Details In this double-blind trial,...

issues in oncology
issues in oncology
issues in oncology

Few Oncology Drugs Approved on Surrogate Endpoints Currently Have Evidence of Survival Benefit

In a study reported in a research letter in JAMA Internal Medicine, Kim and Prasad found that few oncology drugs receiving FDA approval on the basis of surrogate endpoints currently have evidence of an overall survival benefit. In the study, all approvals from January 1, 2008, through December 31, ...

leukemia
issues in oncology

Reduced Relapse but No Quality-of-Life Benefit With ATRA/Arsenic Trioxide vs ATRA/Idarubicin in Acute Promyelocytic Leukemia

In a UK-based phase III trial (AML17) reported in The Lancet Oncology, Burnett et al found that a chemotherapy-free regimen of arsenic trioxide plus all-trans retinoic acid (ATRA) did not improve quality of life, the primary endpoint, vs ATRA plus idarubicin in patients with acute promyelocytic...

breast cancer
issues in oncology

29-Year Single-Center Longitudinal Experience Indicates 2% Annual Risk of Breast Cancer in Lobular Carcinoma in Situ

As reported by King et al in the Journal of Clinical Oncology, 29-year longitudinal experience at Memorial Sloan Kettering Cancer Center indicates an annual 2% risk of breast cancer in women with lobular carcinoma in situ. Risk was reduced with chemoprevention. Study Details The study involved...

colorectal cancer
issues in oncology

Extended RAS Mutation Testing in Metastatic Colorectal Cancer to Predict Response to Anti-EGFR Antibody Therapy

As reported in the Journal of Clinical Oncology by Allegra et al, ASCO has issued a provisional clinical opinion (PCO) update on extended RAS mutation testing in metastatic colorectal cancer to predict response to anti-EGFR monoclonal antibody treatment. The update revises a 2009 PCO and is based...

issues in oncology

Cardiovascular Prevention Trial Shows Reduction in Invasive Breast Cancer Risk With Mediterranean Diet Supplemented by Extra-Virgin Olive Oil

As reported in JAMA Internal Medicine by Toledo et al, a large Spanish primary prevention nutrition intervention trial in patients at high cardiovascular risk (PREDIMED) showed a large reduction in risk for invasive breast cancer among women 60 to 80 years of age who were randomly assigned to the...

breast cancer
issues in oncology

Breast Tumor Genomic Characteristics Suggest More Aggressive Biology in African American vs White Women

In a study reported in the Journal of Clinical Oncology, Keenan et al found that African American women with breast cancer had greater intratumor genetic heterogeneity, a higher frequency of TP53 mutation, and higher risk for basal tumors compared with white women, with the characteristics...

lung cancer
issues in oncology

Study Finds No Disease-Free Survival Improvement With Adjuvant Erlotinib in EGFR-Expressing NSCLC

In the phase III RADIANT trial reported in the Journal of Clinical Oncology, Kelly et al found no disease-free survival improvement with adjuvant erlotinib (Tarceva) vs placebo in patients with EGFR-expressing stage IB to IIIA non–small cell lung cancer (NSCLC). However, there was evidence of ...

colorectal cancer
issues in oncology

Study Finds Racial Differences in BRAF/KRAS Mutation and Disease-Free Survival in Patients With Stage III Colon Cancer

In a study reported in the Journal of the National Cancer Institute, Yoon et al found that among patients with stage III colon cancer in the Alliance N0147 trial, Asians had the lowest rate of BRAF/KRAS mutations and longer disease-free survival vs whites among patients with N2 disease and that...

issues in oncology
gynecologic cancers
issues in oncology

Study Explores Link Between MAPK Pathway Alteration and Long-Term Response to MEK Inhibitor in Serous Ovarian Cancer

In a study reported in the Journal of Clinical Oncology, Grisham et al identified a novel alteration in the MAP2K1 gene encoding for MEK1 that appeared to explain a complete response ongoing for more than 5 years in a patient treated with the MEK inhibitor selumetinib for metastatic low-grade...

leukemia
myelodysplastic syndromes
issues in oncology

Study Explores Link Between Allele Expression and Risk of Graft-vs-Host Disease in Transplant Recipients

In a study reported in The New England Journal of Medicine, Petersdorf et al found a greater risk of acute graft-vs-host disease among hematopoietic cell transplant recipients with the high-expression rs9277534G allele linked to mismatched HLA-DPB1 who received transplants from donors with the...

leukemia
issues in oncology

Persistent Leukemia-Associated Mutations After Induction Therapy Predict Poorer Outcome in AML

In a study reported in JAMA, Klco et al found that persistence of leukemia-associated mutations in ≥ 5% of bone marrow cells at remission predicted poorer outcome among patients with acute myeloid leukemia (AML), including those with intermediate-risk disease. Study Details In the study,...

breast cancer
supportive care
survivorship
issues in oncology

Sham and Real Electroacupuncture Reduce Hot Flashes vs Gabapentin and Pill Placebo in Breast Cancer Survivors

In a study assessing placebo effects reported in the Journal of Clinical Oncology, Mao et al found that sham electroacupuncture produced a greater reduction in hot flashes than placebo pills and gabapentin, with the greatest reduction being achieved with real electroacupuncture. Study Details In...

lymphoma
issues in oncology

Integration of Mutation Status to FLIPI Improves Risk Stratification for Patients Receiving First-Line Immunochemotherapy for Follicular Lymphoma

In a study reported in The Lancet Oncology, Pastore et al found that the addition of mutation status of seven genes to the Follicular Lymphoma International Prognostic Index (FLIPI) and Eastern Cooperative Oncology Group (ECOG) performance status produced a clinicogenetic model (m7-FLIPI) with high ...

breast cancer
health-care policy
issues in oncology

Introduction of Generic Aromatase Inhibitors Reduces Decline in Adherence in Medicare D Breast Cancer Patients Without Low-Income Subsidy

Adherence to aromatase inhibitor treatment for breast cancer declines over time. In a study reported in the Journal of the National Cancer Institute, Neuner et al found that introduction of generic aromatase inhibitors resulted in a reduction in decline in adherence among patients with breast...

issues in oncology
lymphoma

Digital Gene Expression Cell of Origin Assay Shows High Prognostic Ability in Diffuse Large B-Cell Lymphoma

In a study reported in the Journal of Clinical Oncology, Scott et al found that the digital gene expression–based Lymph2Cx assay produced concordant cell of origin assignments in formalin-fixed paraffin-embedded tissue biopsies from patients with diffuse large B-cell lymphoma and showed high...

supportive care
issues in oncology

Rolapitant Reduced Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Highly Emetogenic Cisplatin-Based Chemotherapy

In two phase III trials reported in The Lancet Oncology, Rapoport et al found that the addition of rolapitant to serotonin (5-HT3) receptor antagonist and dexamethasone treatment significantly improved complete response rates in prevention of chemotherapy-induced nausea and vomiting in patients...

supportive care
issues in oncology

Rolapitant Reduced Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Moderately Emetogenic Chemotherapy or Anthracycline/Cyclophosphamide

In a phase III study reported in The Lancet Oncology, Schwartzberg et al found that the addition of rolapitant to serotonin (5-HT3) receptor antagonist and dexamethasone treatment significantly improved complete response rates in prevention of chemotherapy-induced nausea and vomiting in patients...

gynecologic cancers
issues in oncology

Analysis Indicates That Tubal Ligation Is Associated With Lower Endometrial Cancer Stage at Diagnosis and Improved Survival

In an analysis from the NRG Oncology/Gynecologic Oncology Group 210 trial reported in the Journal of the National Cancer Institute, Felix et al found that tubal ligation, which should impede transtubal passage of cells, was associated with lower stage of endometrial cancer at presentation and...

breast cancer
issues in oncology

Hypofractionation of Breast Radiotherapy Associated With Reduced Acute Toxicity

In an analysis reported in JAMA Oncology, Jagsi et al found that hypofractionation of whole-breast radiotherapy was associated with reduced acute toxicity compared with conventional fractionation. Study Details The study involved data on physician-assessed toxic effects and patient-reported...

breast cancer
issues in oncology
issues in oncology

Most Stage-Specific Survival Improvement in Women With Breast Cancer Under Age 70 Is Not Explained by Tumor Size or Estrogen Receptor Status

In an analysis reported in the Journal of Clinical Oncology, Park et al found that most of the improvement in breast cancer–specific mortality observed over time in the United States is not explained by tumor size or estrogen receptor status in women aged < 70 years, suggesting a major...

breast cancer
issues in oncology

Reduced Short-Term Effects With Hypofractionated Whole-Breast Irradiation After Breast-Conserving Surgery

In a randomized trial reported in JAMA Oncology, Shaitelman et al found that hypofractionated whole-breast irradiation resulted in reduced short-term effects compared with conventional fractionation in women with stage 0 to II breast cancer undergoing breast-conserving surgery. Study Details In...

head and neck cancer
issues in oncology

Susceptibility Gene Identified for Familial Nonmedullary Thyroid Cancer

As reported in The New England Journal of Medicine, Gara et al identified a germline HABP2 mutation as a susceptibility gene for familial nonmedullary thyroid cancer. Identification of HABP2 Variant In a kindred study, whole-exome sequencing was performed using peripheral blood DNA from affected...

gynecologic cancers
issues in oncology

Oral Contraceptives May Offer Long-Term Protection From Endometrial Cancer

In an individual-patient meta-analysis reported in The Lancet Oncology, the Collaborative Group on Epidemiological Studies on Endometrial Cancer found that oral contraceptive use was associated with long-term protection from endometrial cancer. Reduction in risk was greater for carcinomas than...

lung cancer
issues in oncology

Sequencing Studies Show High Frequency of Actionable MET Mutations in Pulmonary Sarcomatoid Carcinoma

In a study reported in the Journal of Clinical Oncology by Liu et al, next-generation sequencing revealed a high frequency of actionable MET mutations in patients with pulmonary sarcomatoid carcinoma. Study Details In the study, whole-exome sequencing was used in a discovery set of 10 patients...

health-care policy
issues in oncology
issues in oncology

ASCO Statement: Improving the Evidence Base for Treating Older Adults With Cancer

Older persons are the fastest growing segment of the U.S. population and account for the majority of cancer diagnoses and deaths and the majority of cancer survivors. However, since this population is underrepresented in clinical trials, the evidence base for treating older patients is poor. As...

breast cancer
issues in oncology

17-Year Follow-up Indicates Early but Not Overall Reduction in Breast Cancer Mortality With Annual Mammography Screening at Age 40-49 Years

The 17-year follow-up in the UK Age trial, reported in The Lancet Oncology by Moss et al, indicated a reduction in breast cancer mortality during the first 10 years after diagnosis but not thereafter among women invited for annual mammography screening from age 40 to 49 years compared with...

issues in oncology
prostate cancer

Biomarker Signature May Predict Aggressive Disease in African American Men With Prostate Cancer

In a study reported in Journal of Clinical Oncology, Yamoah et al identified a biomarker signature that may predict aggressive disease in African American men with prostate cancer. Study Details In the study, distribution of mRNA expression levels of 20 biomarkers associated with prostate cancer...

issues in oncology
breast cancer

Pretreatment TNF Level May Be Associated With Memory Impairment in Women With Newly Diagnosed Breast Cancer

In a study reported in the Journal of the National Cancer Institute, Patel et al found that inflammatory cytokine levels were associated with poorer memory function in women with newly diagnosed breast cancer, with higher pretreatment levels of soluble tumor necrosis factor (TNF) receptor type ...

issues in oncology

ASCO Statement: A Conceptual Framework to Assess the Value of Cancer Treatment Options

As reported by Schnipper et al in the Journal of Clinical Oncology, the ASCO Value in Cancer Care Task Force has released an ASCO statement detailing a conceptual framework to assess the value of cancer treatment options. The aim of ASCO in developing the framework is to encourage more...

issues in oncology

Emergency Department Febrile Neutropenia Pathway for Patients With Cancer Reduces Time to Antibiotic Administration

In a study reported in the Journal of Oncology Practice, Keng et al at Cleveland Clinic found that institution of an emergency department febrile neutropenia pathway for patients with cancer reduced the time to antibiotic administration compared with historical and direct admission cohorts....

breast cancer
issues in oncology

County-Based Analysis Suggests Widespread Overdiagnosis of Breast Cancer in Mammography Screening

In a study reported in JAMA Internal Medicine, Harding et al found that on the county level in the United States, mammography screening for breast cancer is associated with an increase in detection of small breast cancers but no reduction in breast cancer mortality. Study Details This ecologic...

colorectal cancer
issues in oncology

Reemergence of Racial Disparity in Use of Adjuvant Chemotherapy in Stage III Colon Cancer

In an analysis reported in the Journal of Clinical Oncology, Murphy et al found that disparity in the use of adjuvant chemotherapy in white vs black patients with stage III colon cancer may have recently reemerged after a trend of increasing use in both racial groups.   Changes in Use Over...

issues in oncology
colorectal cancer

Circulating DNA and Protein Biomarkers May Be Associated With Benefit of Regorafenib in Metastatic Colorectal Cancer

In a retrospective study reported in The Lancet Oncology, Tabernero et al used commercially available BEAMing technology to assess plasma tumor DNA and protein levels in a subgroup of patients from the CORRECT trial of regorafenib (Stivarga) in metastatic colorectal cancer and examined the...

breast cancer
issues in oncology

Successful Preservation of Fertility After Aromatase Inhibitor Treatment and Ovarian Stimulation in Women With Breast Cancer

In a study reported in the Journal of Clinical Oncology, Oktay et al found that fertility could be preserved in women with breast cancer via embryo freezing after concurrent aromatase inhibitor treatment and ovarian stimulation. In the study, 131 women with stage ≤ III breast cancer underwent...

colorectal cancer
issues in oncology

Modeling Indicates Greater Benefit Without Greater Cost for Increased Colorectal Adenoma Detection Rate in Colonoscopy Screening

In a study reported in JAMA by Meester et al, microsimulation modeling of data from a U.S. community-based health-care system showed that colorectal cancer incidence and mortality were reduced with increased adenoma detection rate in colonoscopy screening, with no increase in total costs. Study...

cns cancers
issues in oncology

Molecular Classification of Glioma Based on IDH Mutation, 1p/19q Codeletion, and TERT Promoter Mutation Status

In a study reported in The New England Journal of Medicine, Eckel-Passow et al identified a molecular classification scheme for gliomas based on IDH mutation, codeletion of chromosome arms 1p and 19q (1p/19q codeletion), and TERT promoter mutation status. Molecular Classification The study...

breast cancer
issues in oncology

Differences in Patient-Reported Outcomes but Not Global Quality of Life With Exemestane vs Tamoxifen in Early Breast Cancer With Ovarian Suppression

In a pooled analysis of the TEXT and SOFT trials reported in The Lancet Oncology, Bernhard et al found no difference in global quality of life with exemestane vs tamoxifen in women with early breast cancer undergoing ovarian suppression. The two agents were associated with differences in specific...

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