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Your search for Matthew Stenger matches 419 pages

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breast cancer
issues in oncology

Four-Gene Model Predicts Response to Aromatase Inhibitor Therapy for Breast Cancer

As reported in the Journal of Clinical Oncology, Turnbull et al identified a four-gene predictive model of response to aromatase inhibitor therapy that was highly predictive of response on the basis of pretreatment and 2-week on-treatment measurements. The classifier was a significant predictor of...

prostate cancer
issues in oncology

Transient Adverse Quality-of-Life Impact of Radiotherapy Added to Androgen-Deprivation Therapy in Locally Advanced Prostate Cancer

In a study reported in the Journal of Clinical Oncology, Brundage et al found that the addition of radiotherapy to androgen-deprivation therapy in patients with locally advanced prostate cancer in the NCIC CTG PR3/MRC PR07 trial had a transient negative impact on health-related quality of life over ...

issues in oncology
prostate cancer
issues in oncology
issues in oncology

Whole-Exome Sequencing Identifies Biologically Informative Alterations in the Majority of Metastatic Cancers

In a study reported in JAMA Oncology, Beltran et al found that whole-exome sequencing of metastatic and treatment-resistant cancers revealed biologically informative alterations in the majority of cases. Although treatment recommendations could be made in the majority of cases, treatment was guided ...

breast cancer
issues in oncology
issues in oncology
issues in oncology

Large Survival Disparity Within 2 Years of Diagnosis for Black vs White Women With ER-Positive Breast Cancer

In a study assessing factors in racial/ethnic survival disparities in breast cancer reported in the Journal of Clinical Oncology, Warner et al found that black women with estrogen receptor (ER)-positive breast cancer were significantly more likely to die from the disease within the first 2 years of ...

cns cancers
issues in oncology

Assay Permits Rapid Molecular Characterization of Glioma

As reported in JAMA Oncology, Shankar et al developed a rapid genotyping assay to detect single nucleotide variants in telomerase reverse transcriptase (TERT) promoter and isocitrate dehydrogenase 1 (IDH1) genes that may assist in intraoperative decisions to perform definitive neurosurgical...

palliative care
issues in oncology
skin cancer
issues in oncology

Pooled Analysis Shows Similar Efficacy of Nivolumab in BRAF V600–Mutant and BRAF Wild-Type Advanced Melanoma

A pooled analysis of four clinical trials of nivolumab (Opdivo) in advanced melanoma, reported by Larkin et al in JAMA Oncology, suggested similar response rates in patients with BRAF V600–mutant and BRAF wild-type disease. Study Details The retrospective analysis included data from adult...

colorectal cancer
issues in oncology

Specific Mutations in KRAS Codon 12 Associated With Poorer Overall Survival in Patients With Colorectal Liver Metastases

In a single-institution study reported in JAMA Surgery, Margonis et al found that particular KRAS codon 12 mutations were associated with significantly poorer overall survival among patients with colorectal liver metastases. Study Details This retrospective study included data from 331 patients...

breast cancer
issues in oncology

Denosumab Reduces Clinical Fracture Risk in Postmenopausal Women Receiving Aromatase Inhibitors

In a phase III trial (ABCSG-18) reported in The Lancet, Gnant et al found that adjuvant denosumab (Xgeva) reduced the risk of clinical fracture in women with breast cancer receiving aromatase inhibitor therapy. Study Details In the double-blind study, 3,420 women from Austria and Sweden with...

issues in oncology
issues in oncology
issues in oncology
issues in oncology

Low Enrollment in Genomically Matched Clinical Trials After Genomic Testing

In an analysis reported in the Journal of Clinical Oncology, Meric-Bernstam and colleagues at The University of Texas MD Anderson Cancer Center found that a small minority of patients with potentially actionable genes identified in large-scale testing were enrolled onto clinical trials targeting...

supportive care
issues in oncology

Need for Mental Health Services for Parents Who Lose a Child to Cancer

In a study reported in the Journal of Clinical Oncology, Lichtenthal et al found that parents who have lost a child to cancer report wanting and frequently using mental health services, although barriers to seeking care exist and retention in care is suboptimal. Study Details The cross-sectional...

kidney cancer
issues in oncology
issues in oncology

16-Gene Assay Recurrence Score Predicts Recurrence After Surgery for Localized Renal Cell Carcinoma

In a study reported in The Lancet Oncology, Rini et al developed a 16-gene assay and recurrence score that predicted postsurgery outcome in patients with stage I to III clear cell renal cell carcinoma. Development Phase In the development phase, examination of the association between expression...

leukemia
issues in oncology

DNMT3A Mutations Predict Poorer Outcome in Younger Adults With AML Irrespective of NPM1 Genotype, but Type of Mutation Matters

In a UK study reported in the Journal of Clinical Oncology, Gale et al found that presence of DNMT3A mutations was associated with poorer prognosis in young adults with cytogenetic intermediate-risk acute myeloid leukemia (AML) irrespective of the presence of NPM1 mutation. Poorer outcome was found ...

lung cancer
issues in oncology

Pooled Analysis Shows Activity of Afatinib Differs in NSCLC According to Uncommon EGFR Mutations

In a pooled analysis of the LUX-Lung 2, 3, and 6 trials reported in The Lancet Oncology, Yang et al found that the activity of afatinib (Gilotrif) differed according to uncommon EGFR mutations in advanced non–small cell lung cancer (NSCLC). Most patients with EGFR-mutant NSCLC have deletion...

gynecologic cancers
issues in oncology

Risk Algorithm Using Serial CA-125 Measurements Increases the Number of Screen-Detected Ovarian Cancers

As reported in the Journal of Clinical Oncology by Menon et al, findings in the United Kingdom Collaborative Trial of Ovarian Cancer Screening indicate that the number of screen-detected ovarian cancers is doubled by using the risk of ovarian cancer algorithm (ROCA) with serial CA-125 measurements...

cns cancers
issues in oncology

Addition of Bevacizumab to Radiotherapy and Temozolomide Does Not Worsen Health-Related Quality of Life in Glioblastoma Patients

In the phase III AVAglio trial, the addition of bevacizumab (Avastin) to radiotherapy and temozolomide improved progression-free survival in patients with newly diagnosed glioblastoma. As reported by Taphoorn et al in the Journal of Clinical Oncology, bevacizumab treatment did not worsen...

issues in oncology
breast cancer

Higher Tumor-Infiltrating Lymphocyte Level Associated With Better Outcomes in HER2-Positive Early Breast Cancer Independent of Neoadjuvant Treatment

In an analysis of the NeoALTTO trial reported in JAMA Oncology, Salgado et al found that a higher level of tumor-infiltrating lymphocytes was associated with improved pathologic compete response rate and event-free survival independent of neoadjuvant treatment received in patients with...

breast cancer
issues in oncology

Minority of Medicare Patients Have Adequate Cardiac Monitoring During Adjuvant Trastuzumab-Based Chemotherapy for Breast Cancer

In a study reported in the Journal of Clinical Oncology, Chavez-MacGregor et al found that the majority of older breast cancer patients receiving trastuzumab (Herceptin)-based chemotherapy do not receive adequate cardiac monitoring. Study Details The study involved 2,203 patients aged ≥...

breast cancer
issues in oncology

Polish Study Shows Inherited PALB2 Mutation Confers Greater Risk and Poorer Outcome of Breast Cancer

In a Polish prospective cohort analysis reported in The Lancet Oncology, Cybulski et al found that PALB2 mutation carriers had increased risk of breast cancer and that those with breast cancer had significantly reduced long-term survival.  Study Details In the study, genotyping for two...

breast cancer
supportive care
issues in oncology

Omega-3 Fatty Acids and Placebo Reduce Aromatase Inhibitor–Related Musculoskeletal Pain in Early Breast Cancer

In the SWOG S0927 trial reported in the Journal of Clinical Oncology, Hershman et al found that both omega-3 fatty acids and placebo resulted in marked persistent reductions in aromatase inhibitor–related arthralgia among patients with early breast cancer, with no difference between...

breast cancer
issues in oncology

Physical Activity Programs Produce Benefits in Patients Receiving Adjuvant Therapy for Breast Cancer

In the Dutch PACES trial reported in the Journal of Clinical Oncology, van Waart et al found that both a moderate/high-intensity supervised exercise program and a low-intensity home-based program provided benefits vs usual care in women undergoing adjuvant chemotherapy for breast cancer. Benefits,...

pancreatic cancer
issues in oncology

Germline BRCA Mutations Found in Almost 5% of Patients With Pancreatic Adenocarcinoma

In a study reported in the Journal of Clinical Oncology, Holter et al found that 4.6% of a large clinic population of patients with pancreatic adenocarcinoma harbored pathogenic germline BRCA mutations. The study involved analysis of 306 unselected, consecutive, incident patients with pancreatic...

issues in oncology

ASCO Provisional Clinical Opinion Update: HBV Screening for Cancer Patients Before Cancer Therapy

As reported in the Journal of Clinical Oncology by Hwang et al, ASCO has released a provisional clinical opinion update on screening of cancer patients for hepatitis B virus (HBV) infection before cancer treatment to reduce the risk of HBV reactivation. The ASCO consensus panel providing the update ...

breast cancer
issues in oncology

Dutch Analysis Questions Breast Cancer Protective Effect of Salpingo-Oophorectomy in Healthy BRCA1/2 Mutation Carriers

In a Dutch study reported in the Journal of the National Cancer Institute, Heemskerk-Gerritsen et al in the Hereditary Breast and Ovarian Cancer in the Netherlands (HEBON) study group found no apparent reduction in the risk for breast cancer with salpingo-oophorectomy in healthy BRCA1/2 mutation...

issues in oncology

High Symptom Distress in Children With Advanced Cancer

As reported in the Journal of Clinical Oncology by Wolfe et al, the Pediatric Quality of Life and Evaluation of Symptoms Technology (PediQUEST) study found a high prevalence of disease symptoms in children with advanced cancer, with most symptoms being associated with high distress level. Study...

lung cancer
issues in oncology

Targeted Massively Parallel Sequencing Study Indicates Similarity of Somatic Driver Mutations in NSCLC for African American vs European Ancestry

In a study reported in the Journal of Clinical Oncology, Araujo et al used targeted massively parallel sequencing to produce an in-depth molecular profile of non–small cell lung cancer (NSCLC) in African Americans. Comparison with findings in patients of European/white ancestry with NSCLC...

breast cancer
issues in oncology

CEP17 or TOP2A Aberrations Predict Benefit of Adjuvant Anthracycline-Based Chemotherapy in Breast Cancer

In a study reported in the Journal of Clinical Oncology, Bartlett et al found that the presence of duplication of chromosome 17 pericentromeric alpha satellite, measured by a centromere enumeration probe (CEP17), and TOP2A aberrations predicted benefit of anthracycline-based adjuvant therapy in...

prostate cancer
issues in oncology

Enzalutamide Improves Patient-Reported Outcomes and Time to Skeletal-Related Event vs Placebo in PREVAIL Trial

The PREVAIL trial showed that enzalutamide (Xtandi) improved overall survival and progression-free survival vs placebo in asymptomatic/minimally symptomatic chemotherapy-naive patients with metastatic castration-resistant prostate cancer. In analyses reported in The Lancet Oncology, Loriot et al...

colorectal cancer
issues in oncology

Frequency of Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer Not Meeting Criteria for Li-Fraumeni Syndrome

In a study reported in JAMA Oncology, Yurgelun et al identified germline TP53 mutations in multiple patients with early-onset colorectal cancer from the Colon Cancer Family Registry who did not meet clinical criteria for Li-Fraumeni syndrome. Li-Fraumeni syndrome is associated with increased risk...

hepatobiliary cancer
issues in oncology

Statin Use Is Associated With Reduced Risk of Primary Liver Cancer in Low-Prevalence Setting

In a study reported in the Journal of the National Cancer Institute, McGlynn et al found that statin use was associated with a reduced risk of primary liver cancer in a setting of low liver cancer prevalence. Other studies have shown a preventive benefit of statin therapy in regions of the world...

breast cancer
issues in oncology

Platinum Monotherapy Particularly Active in BRCA1/2-Mutant Metastatic Triple-Negative Breast Cancer

In the phase II TBCRC009 trial reported in the Journal of Clinical Oncology, Isakoff et al found that platinum monotherapy was active in treatment of metastatic triple-negative breast cancer, particularly in cases with BRCA1/2 mutation, and that an assay of genomic instability characteristic of...

issues in oncology

Weak Relationship Between Surgical Oncologic Perioperative Morbidity and Publicly Reported Hospital Quality and Satisfaction Measures

In a study reported in the Journal of the National Cancer Institute, Wright et al found a weak relationship between measures of patient satisfaction and quality and surgical oncologic perioperative outcomes at the hospital level. Study Details In the study, the Nationwide Inpatient Sample...

issues in oncology

Low Use of Decision Aids for Localized Prostate Cancer by Radiation Oncologists and Urologists

In a survey study reported in JAMA Internal Medicine, Wang et al found that a minority of responding radiation oncologists and urologists used decision aids for localized prostate cancer in clinical practice. Study Details In the study, a survey regarding use of and attitudes toward decision aids ...

supportive care
issues in oncology

No Differences in Patient-Reported Outcomes or Resource Use With Early vs Delayed Initiation of Palliative Care Intervention

In the ENABLE III study reported in the Journal of Clinical Oncology, Bakitas et al found that early vs delayed initiation of a palliative care intervention did not result in improved patient-reported outcomes or resource use. Early initiation was associated with better 1-year survival. Study...

supportive care
issues in oncology

Reduced Family Caregiver Depression With Early vs Delayed Palliative Care Intervention for Caregivers

In the ENABLE III study reported in the Journal of Clinical Oncology, Dionne-Odom et al found that early vs delayed use of a palliative care intervention for family caregivers of patients with advanced cancer reduced caregiver depression scores and caregiver stress burden. No differences in...

breast cancer
issues in oncology

Insufficient Awareness of Breast Density and Its Impact on Breast Cancer Detection and Risk

In a study reported in the Journal of Clinical Oncology, Rhodes et al found that only about half of screening-age women had awareness of breast density and adequate knowledge of its impact on breast cancer detection and risk. Breast density is an important factor contributing to false-negative...

lung cancer
issues in oncology

Decline in Proportion of Lung Cancer Patients Meeting Screening Criteria

In a study reported in a research letter in JAMA, Wang et al found that the proportion of patients with lung cancer who would have met U.S. Preventive Services Task Force (USPSTF) criteria for low-dose computed tomography (CT) lung screening decreased significantly between the periods of 1984 to...

solid tumors
issues in oncology

Comprehensive Genomic Profiling Shows Distribution of Targetable Alterations in Carcinomas of Unknown Primary Site

In a study reported in JAMA Oncology, Ross et al found potentially targetable genomic alterations in most carcinomas of unknown primary site using comprehensive genomic profiling. Adenocarcinomas of unknown primary site frequently harbored receptor tyrosine kinase/Ras/MAPK pathway alterations....

breast cancer
issues in oncology

Reduced Mammography Rates 3 Years After 2009 U.S. Preventive Services Task Force Guidelines Changes

In a study reported in the Journal of Clinical Oncology, Wharam et al found that estimated mammography rates were lower than predicted in white, Hispanic, and Asian women since the U.S. Preventive Services Task Force (USPSTF) changed its screening recommendations in November 2009. The guidelines...

lung cancer
issues in oncology

Outcomes of Phase II Basket Trial of Molecular Profiling and Targeted Therapy in Advanced Thoracic Malignancies

In a basket trial (CUSTOM) reported in the Journal of Clinical Oncology, Lopez-Chavez et al performed molecular profiling of tumors in patients with advanced non–small cell lung cancer (NSCLC), small cell lung cancer, or thymic malignancies and assigned those in any of five actionable...

breast cancer
issues in oncology

MRI Screening More Sensitive Than Mammography and Ultrasound for Familial Breast Cancer Irrespective of Age, Mutation Status, or Breast Density

In a single-center study reported in the Journal of Clinical Oncology, Riedl et al found that screening with magnetic resonance imaging (MRI) had greater sensitivity for detection of breast cancer in high-risk women vs mammography or ultrasound irrespective of age, mutation status, or breast...

colorectal cancer
issues in oncology

Greater Guideline Adherence, Better Survival, Absence of Racial Survival Disparity Among Colorectal Cancer Patients in Integrated Health-Care System

In a retrospective analysis reported in the Journal of Clinical Oncology, Rhoads et al found that treatment of colorectal cancer patients in an integrated health-care system was associated with greater compliance with National Comprehensive Cancer Network (NCCN) guidelines, better survival, and no...

prostate cancer
issues in oncology

Simulation Study Based on ERSPC Data Shows Greatest Cost-Effectiveness With Two to Three PSA Screenings Between 55 and 59 Years of Age

The European Randomized Study of Screening for Prostate Cancer (ERSPC) trial showed a significant 29% prostate cancer mortality reduction with prostate-specific antigen (PSA) screening but a marked negative impact on quality-adjusted life-years gained due to the effect of overdiagnosis on quality...

breast cancer
issues in oncology

Lower Household Net Worth and Black Race Associated With Nonadherence to Hormonal Therapy for Early-Stage Breast Cancer

In a study reported in the Journal of Clinical Oncology, Hershman et al found that nonadherence to adjuvant hormonal therapy for early-stage breast cancer was more common among black women and patients with lower household net worth, with the latter factor partly accounting for the racial...

colorectal cancer
issues in oncology

Colorectal Cancer Benefits With Flexible Sigmoidoscopy Screening in SCORE Trial Are Generalizable to Broader Population

The Italian SCORE trial is among several recent large European randomized trials showing the benefit of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality. In a study reported in the Journal of the National Cancer Institute, Senore et al found that characteristics of...

breast cancer
issues in oncology

Decision Aid Including Information on Overdetection Increases Informed Choice in Breast Screening and Reduces Intention to Be Screened

In a study reported in The Lancet, Hersch et al found that use of a decision aid containing information on overdetection in breast cancer screening was associated with an increased rate of informed choice regarding screening, a reduced rate of positive attitudes toward screening, and reduced...

issues in oncology

Patient Request/Demand for Clinically Inappropriate Intervention Uncommon in Outpatient Setting

Increases in medical costs are often attributed to ‘demanding’ patients. In a study reported in JAMA Oncology, Gogineni et al found that approximately 9% of patient encounters in outpatient oncology clinics included patient demands or requests for tests or treatment, that the majority...

lymphoma
issues in oncology

No Difference in Anxiety or Health-Related Quality of Life in NHL Patients Receiving Rituximab Maintenance vs Retreatment at Disease Progression

In an analysis among patients in the Eastern Cooperative Oncology Group (ECOG) E4402 trial (RESORT) reported in the Journal of Clinical Oncology, Wagner et al found no difference in anxiety or health-related quality of life in patients with low–tumor burden non-Hodgkin lymphoma who received...

breast cancer
issues in oncology

Higher Folate Intake Associated With Reduced Risk of Hormone Receptor–Negative Breast Cancer in Premenopausal Women

In an analysis from the European Prospective Investigation Into Cancer and Nutrition (EPIC) reported in the Journal of the National Cancer Institute, de Batlle and colleagues found reduced risks of estrogen receptor–negative and progesterone receptor–negative breast cancer for highest...

issues in oncology

TP53 Mutations Common in Pediatric Adrenocortical Carcinoma

In a Children’s Oncology Group study reported in the Journal of Clinical Oncology, Wasserman et al found that germline TP53 mutations are common in children with adrenocortical carcinoma, with mutations encoding proteins with greater loss of function being at increased risk of multiple...

colorectal cancer
issues in oncology

Active Smoking Increases Mortality in Nonmetastatic Colorectal Cancer, Both Pre- and Postdiagnosis

In a study reported in the Journal of Clinical Oncology, Yang et al found that current smoking was associated with increased colorectal cancer–specific and all-cause mortality among colorectal cancer patients in both the prediagnosis and postdiagnosis settings. Study Details The study...

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