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Your search for Matthew Stenger matches 419 pages

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gynecologic cancers
issues in oncology

No Reduction in Quality of Life With Addition of Bevacizumab to Chemotherapy in GOG 240 Trial in Advanced Cervical Cancer

The phase III Gynecologic Oncology Group (GOG) 240 trial showed that the addition of bevacizumab (Avastin) to chemotherapy prolonged survival in patients with advanced cervical cancer. An analysis reported in The Lancet Oncology by Penson et al showed no reduction in quality of life among patients...

breast cancer
issues in oncology

Immune Gene Profile Strongly Associated With Benefit of Adjuvant Trastuzumab in HER2-Positive Breast Cancer

In a study reported in the Journal of Clinical Oncology, Perez et al found that an immune function gene profile was associated with significantly improved relapse-free survival among patients with early-stage HER2-positive breast cancer who had trastuzumab (Herceptin) added to adjuvant chemotherapy ...

issues in oncology

Age-Related Clonal Hematopoiesis Associated With Increased Risk of All-Cause Mortality, Heart Disease, and Stroke, as Well as Blood Cancer

In a study reported in The New England Journal of Medicine, Jaiswal et al found somatic mutations associated with hematologic cancers at increasing frequency with increasing age, with presence of the mutations being associated with increased risk of hematologic cancers, all-cause mortality,...

hematologic malignancies
issues in oncology

Clonal Hematopoiesis With Somatic Mutations Increases With Age and Increases Risk of Hematologic Cancer and Mortality

In a study reported in The New England Journal of Medicine, Genovese et al found that clonal hematopoiesis with somatic mutations is increasingly common with greater age and is associated with increased risk of hematologic cancer. The presence of such clonal hematopoiesis in apparently healthy...

colorectal cancer
issues in oncology

Genetic Diagnosis by Exome Sequencing Feasible for Familial Colorectal Cancer

In a study reported in the Journal of Clinical Oncology, Chubb et al found that genetic diagnosis of high-penetrance susceptibility to colorectal cancer can be achieved in a sizeable proportion of familial colorectal cancer cases via exome sequencing for germline mutations. Study Details The...

issues in oncology

Poor Geographic Accessibility of Advanced Cancer Clinical Trial Sites

It is estimated that approximately 2% to 7% of U.S. adult patients with cancer participate in clinical trials, and poor geographic accessibility of clinical trial sites contributes to this low participation. In a study reported in JAMA Internal Medicine, Galsky et al found that approximately 40% to ...

leukemia
issues in oncology

Allogeneic Stem Cell Transplantation Prolongs Recurrence-Free Survival in NPM1-Mutant AML

In an analysis of the Study Alliance Leukemia (SAL) AML 2003 trial reported in the Journal of Clinical Oncology, Röllig et al found that allogeneic stem cell transplantation significantly prolonged recurrence-free survival in patients with NPM1-mutant acute myeloid leukemia (AML). NPM1...

supportive care
issues in oncology

Cognitive Behavioral Therapy Improves Insomnia After Cancer Treatment With No Difference in Combination With Placebo or Armodafinil

In a study reported in Journal of Clinical Oncology, Roscoe et al found that cognitive behavioral therapy combined with placebo or the wakefulness-promoting agent armodafinil (Nuvigil) had similar beneficial effects on insomnia and sleep quality in cancer survivors. Study Details In the study, 96 ...

colorectal cancer
issues in oncology

ASCO Endorses ESMO Guideline on Hereditary Colorectal Cancer Syndromes

Approximately 5% to 6% of cases of colorectal cancer are associated with germline mutations conferring an inherited predisposition for disease. As reported by Stoffel et al in the Journal of Clinical Oncology, ASCO has endorsed, with qualifying statements, the European Society for Medical Oncology...

issues in oncology

Asian Cancer Survivors Report Poorer Care Communication and Care Quality

In a study reported in the Journal of Clinical Oncology, Palmer et al found that Asian cancer survivors reported poorer care communication and care quality compared with white patients. Study Details The study involved 1,196 survivors of breast, prostate, colorectal, ovarian, and endometrial...

supportive care
issues in oncology

Management of Cancer Pain Has Improved but Remains Inadequate

In a study reported in the Journal of Clinical Oncology, Greco et al updated a 2008 systematic review on cancer pain management. Improvements were seen between 2008 and 2013, but approximately one-third of patients still do not receive pain medication adequate for reported pain intensity. Changes...

skin cancer
issues in oncology

Somatic Tumor Neoepitopes as Basis for Response to CTLA-4 Inhibition in Melanoma

The molecular determinants of benefit from immune checkpoint inhibitor treatment have not been characterized. In a study reported in The New England Journal of Medicine, Snyder et al found that benefit of the anti–cytotoxic T-lymphocyte antigen 4 (CTLA-4) antibodies ipilimumab (Yervoy) and...

issues in oncology

Abstract ‘Spin’ Affects Interpretation of Trial Outcome

In the SPIIN study reported in the Journal of Clinical Oncology, Boutron et al found that spin in the abstract of an article reporting results of a randomized controlled trial in cancer increased clinician rating of the benefit of the experimental treatment in the trial. Study Details In the...

colorectal cancer
gynecologic cancers
issues in oncology

Cancer Risk Associated With Lynch Syndrome PMS2 Mutation in European Cohort

The effects of PMS2 germline mutations are less well understood than those of other Lynch syndrome–associated mismatch repair gene mutations. In a European cohort study reported in the Journal of Clinical Oncology, ten Broeke et al found that risks of colorectal cancer and endometrial cancer...

breast cancer
issues in oncology

Telephone Peer-Support Program Reduces Breast Cancer Distress for Women Carrying BRCA Mutation

In an Australian study reported in the Journal of Clinical Oncology, White et al found that a telephone-based peer-support intervention reduced breast cancer distress among women with a BRCA1 or BRCA2 gene mutation. Study Details In the study, 207 mutation carriers reporting interest in talking...

colorectal cancer
issues in oncology

Colon Cancer Gene-Expression Risk Scores Contribute Little to Prognostic Ability of Established Risk Factors

In a study reported in the Journal of the National Cancer Institute, Di Narzo et al found that individual colon cancer gene-expression risk scores contributed little to the prognostic ability of traditional risk factors. Study Details The study involved evaluation of four gene-expression risk...

cns cancers
issues in oncology

Germline SUFU Mutations Cause Gorlin Syndrome and Increase Risk for Childhood Medulloblastoma

In a study to identify causative mutations in patients with Gorlin syndrome without PTCH1 mutations, Smith et al found that germline mutations in SUFU were associated with Gorlin syndrome and with increased likelihood of Gorlin syndrome–associated childhood medulloblastoma. The study is...

breast cancer
issues in oncology

High Frequency of Inherited Mutations in Susceptibility Genes in a Triple-Negative Breast Cancer Cohort Unselected for Family History of Breast Cancer

In a study reported in Journal of Clinical Oncology, Couch et al found a high frequency of inherited mutations in breast cancer susceptibility genes in a cohort of women with triple-negative breast cancer unselected for family history of breast or ovarian cancer. In the study, the frequency of...

issues in oncology

Cigarette Smoking Associated With Changes in Inflammation Markers

In a study reported in the Journal of the National Cancer Institute, Shiels et al found significant changes in levels of inflammatory/immune markers in current cigarette smokers vs nonsmokers. There was a significant relationship between time since quitting and return to nonsmoker levels for...

breast cancer
issues in oncology

Effect of Computer-Aided Detection in Mammography Screening on Cost and DCIS Diagnosis in Medicare Population

In a study reported in a research letter in JAMA Surgery, Fenton et al found that a sizable proportion of ductal carcinoma in situ (DCIS) diagnoses are attributable to computer-aided detection in mammography screening in the Medicare population and that use of computer-aided detection in this...

issues in oncology

CONCORD-2 Study Reveals Wide Variability in Global Cancer Survival Rates

As reported in The Lancet by Allemani et al, the CONCORD-2 study of global cancer survival indicates improvements in survival in many countries in colorectal, breast, and prostate cancers, persistent poor outcomes in lung and liver cancers, and wide variability in survival in many cancers. The...

breast cancer
issues in oncology

More Than 40% of U.S. Women Have Mammographically Dense Breasts

In a study reported in the Journal of the National Cancer Institute, Sprague et al found that more than 40% of U.S. women have mammographically dense breasts, with the prevalence being inversely proportional to age and body mass index (BMI). As noted by the authors: “National legislation is...

issues in oncology

Cigarette Smoking Before Diagnosis of First Cancer Is Associated With Increased Risk of Second Cancers

In a study reported in the Journal of Clinical Oncology, Shiels et al found that prediagnostic smoking among survivors of stage I lung cancer or bladder, kidney, or head/neck cancer was associated with increased risk of second lung, bladder, kidney, and head and neck cancer. Study Details The...

issues in oncology
survivorship

Advanced-Practice Nurse Telephone Counseling Improves Rate of Cardiomyopathy Screening in At‑Risk Adult Survivors of Pediatric Cancer

In the ECHOS trial reported in the Journal of Clinical Oncology, Hudson et al found that the addition of two tailored telephone counseling sessions by an advanced-practice nurse to a mailed personalized survivorship care plan including cardiac screening recommendations resulted in a greater than...

colorectal cancer
issues in oncology

Wide Geographic Variation in Use of Laparoscopic Colectomy for Colon Cancer

There has been a dramatic increase in the use of laparoscopic colectomy for colon cancer. In a Medicare data study reported in the Journal of Clinical Oncology, Reames and colleagues found that use of laparoscopic colectomy varied from 0% to 66.8% across hospital referral regions in the United...

supportive care
issues in oncology

Absence of Residual Thrombosis After 6 Months of Low–Molecular Weight Heparin Indicates Low Risk for Recurrent Cancer-Related Deep-Vein Thrombosis

In an Italian study (Cancer-DACUS) reported in the Journal of Clinical Oncology, Napolitano et al found that patients with no residual vein thrombosis after 6 months of low–molecular weight heparin for a first episode of cancer-related deep-vein thrombosis of the lower limbs had low risk for...

lung cancer
issues in oncology

Crizotinib Highly Active in ROS1-Rearranged NSCLC

In a study reported in The New England Journal of Medicine, Shaw et al found that crizotinib (Xalkori) produced a high response rate in patients with ROS1-rearranged non–small cell lung cancer (NSCLC). Chromosomal rearrangements in ROS1, which encodes the proto-oncogene receptor tyrosine...

breast cancer
issues in oncology

Analysis Suggests 70-Gene Signature Strategy Is Not Cost-Effective in Adjuvant Decisions in Patients With Node-Negative Breast Cancer

In a French analysis reported in the Journal of Clinical Oncology, Bonastre and colleagues found that use of the 70-gene signature (MammaPrint) was unlikely to be cost-effective in deciding whether to administer adjuvant therapy in patients with node-negative breast cancer. Use of Adjuvant! Online...

lung cancer
issues in oncology

Predictive Ability of CT Screen-Detected Nodule Volume, Diameter, and Volume-Doubling for Lung Cancer in NELSON Trial

The Dutch and Belgian NELSON trial is assessing the effect of increasing interval low-dose computed tomography (CT) screening for lung cancer on lung cancer mortality. In an analysis among screened Dutch participants reported in Lancet Oncology, Horeweg and colleagues identified screen-detected...

lung cancer
issues in oncology

Performance of Lung Cancer Low-Dose CT Screening With Increasing Screening Interval in NELSON Trial

The Dutch and Belgian NELSON trial is assessing the effect of increasing interval low-dose computed tomography (CT) screening for lung cancer on lung cancer mortality. In an analysis of screening test performance among Dutch participants reported in Lancet Oncology, Horeweg and colleagues found...

issues in oncology
breast cancer

CLEOPATRA Analysis Shows That HER2 Is Sole Marker Suitable for Selection of Pertuzumab/Trastuzumab-Based Treatment in Metastatic Breast Cancer

In an analysis in the CLEOPATRA trial population reported in the Journal of Clinical Oncology, Baselga et al found that HER2 was the only biomarker suitable for use in selecting patients for first-line pertuzumab (Perjeta)/trastuzumab (Herceptin)-based treatment in patients with HER2-positive...

supportive care
issues in oncology

Adding Aprepitant to Granisetron/Dexamethasone Reduces Chemotherapy-Induced Nausea and Vomiting After High-Dose Melphalan Conditioning in Myeloma

In a phase III trial reported in the Journal of Clinical Oncology, Schmitt et al found that adding aprepitant to granisetron and dexamethasone significantly reduced chemotherapy-induced nausea and vomiting in myeloma patients undergoing high-dose melphalan conditioning and autologous stem cell...

issues in oncology
prostate cancer

AR-V7 in Circulating Tumor Cells Associated With Resistance to Enzalutamide and Abiraterone in Prostate Cancer

The androgen receptor isoform encoded by splice variant 7 is constitutively active as a transcription factor, despite lacking the ligand-binding domain that is the target of enzalutamide (Xtandi) and abiraterone (Zytiga). In a study reported in The New England Journal of Medicine, Antonarakis et al ...

breast cancer
issues in oncology

Little Molecular Difference and No Prognostic Effect of Clinical HER2 Status in Context of Intrinsic Breast Cancer Subtypes

In a study reported in the Journal of the National Cancer Institute, Prat et al found that there was little difference in downstream gene or protein expression according to intrinsic breast cancer subtypes among clinical HER2-positive vs -negative breast cancers and that clinical HER2 status did...

colorectal cancer
issues in oncology

Modeling Study Critical of Intensive Colonoscopy Screening in Medicare Population

A modeling study reported in JAMA Internal Medicine by van Hees and colleagues showed that  colonoscopy screening at intervals shorter than 10 years or continuing past 75 years of age in the Medicare population is associated with a reduced net health benefit from a societal perspective. Study ...

colorectal cancer
issues in oncology

Low Incidence of Colorectal Cancer, Elevated Rate of Postprocedure Hospitalization in Elderly Patients Undergoing Surveillance Colonoscopy

In a retrospective cohort study reported in JAMA Internal Medicine, Tran et al found a low rate of colorectal cancer and a relatively high rate of postprocedure hospitalization in elderly patients undergoing surveillance colonoscopy. Study Details The study involved patients aged ≥ 50 years...

breast cancer
issues in oncology

Analysis of Randomized Bisphosphonate Osteoporosis Trials Indicates No Reduction in Risk of Postmenopausal Breast Cancer

Observational studies have suggested a potential effect of bisphosphonate treatment for osteoporosis in reducing risk of breast cancer in postmenopausal women. However, an analysis of the randomized FIT trial of alendronate and HORIZON-PFT trial of zoledronic acid reported in JAMA Internal Medicine ...

lung cancer
issues in oncology

ALK-Positivity Prevalence on Immunohistochemistry and FISH in Resected Stage I to III Lung Adenocarcinoma

The European Thoracic Oncology Platform Lungscape ALK project is investigating the prevalence and prognostic impact of ALK-positivity in resected lung adenocarcinoma in a primarily European population. As reported in the Journal of Clinical Oncology by Blackhall and colleagues, the project has...

cns cancers
issues in oncology

Study Detects New ALK Mutations at Neuroblastoma Relapse

In a study reported in the Journal of Clinical Oncology, Schleiermacher et al found ALK mutations at relapse of neuroblastoma that were not present at diagnosis. They also found that subclonal mutations may be present at diagnosis with clonal expansion observed at relapse. The study involved...

colorectal cancer
issues in oncology

NORCCAP Trial Shows Reduced Colorectal Cancer Incidence and Mortality With Flexible Sigmoidoscopy Screening at 11-Year Follow-up

The Norwegian Colorectal Cancer Prevention Trial comparing colorectal cancer screening with flexible sigmoidoscopy vs no screening showed no reduction in colorectal cancer incidence or mortality after 7 years of follow-up. As reported by Holme et al in JAMA, the 11-year follow-up shows significant...

prostate cancer
issues in oncology

ERSPC 13-Year Follow-up: Reduction in Prostate Cancer Mortality With PSA Screening, but High Overdiagnosis Rates Remain a Concern, Say Authors

The 13-year follow-up of the European Randomized Study of Screening for Prostate Cancer (ERSPC), reported by Schröder et al in The Lancet, showed that prostate-specific antigen (PSA) screening in men aged 55 to 69 years is associated with a 21% reduction in risk of prostate cancer mortality...

lung cancer
issues in oncology

Comprehensive Molecular Profiling of Lung Adenocarcinoma

The Cancer Genome Atlas Research Network has recently reported its comprehensive molecular profiling of lung adenocarcinoma in Nature. Findings included a high rate of somatic mutations including alterations in tumor-suppressor genes, chromatin-modifying genes, and RNA-splicing genes and suggested...

cns cancers
issues in oncology

Successful Vemurafenib Treatment of Progressive BRAF V600E–Mutated Anaplastic Pleomorphic Xanthoastrocytoma

The BRAF inhibitor vemurafenib (Zelboraf) is approved for treatment of BRAF-mutated metastatic melanoma. There are reports indicating that vemurafenib may be active in the treatment of intracranial neoplasms with BRAF mutations. As reported in the Journal of Clinical Oncology, Lee et al from...

prostate cancer
issues in oncology

Enzalutamide Increases Time to First Skeletal-Related Event and Improves Quality-of-Life Outcomes in Castration-Resistant Prostate Cancer

In the phase III international AFFIRM trial, enzalutamide (Xtandi) was shown to improve overall survival vs placebo in men with metastatic castration-resistant prostate cancer after progression on docetaxel. In an analysis of secondary endpoints reported in The Lancet Oncology, Fizazi et al found...

myelodysplastic syndromes
issues in oncology

TP53, TET2, and DNMT3A Mutations Predict Poorer Survival After Hematopoietic Stem Cell Transplant in Patients With Myelodysplastic Syndrome

It is unclear whether somatic mutations that are strongly associated with phenotype and prognosis in myelodysplastic syndrome are also predictive of outcome after allogeneic hematopoietic stem cell transplantation. In a study reported in the Journal of Clinical Oncology, Bejar et al found that...

breast cancer
issues in oncology

Study Quantifies Risk of Hereditary Breast Cancer in Carriers of PALB2 Mutations

In a study reported in The New England Journal of Medicine, Antoniou et al identified lifetime risk of breast cancer in families with germline loss-of-function mutations in PALB2. Estimated cumulative risk among female mutation carriers was 14% by 50 years of age and 35% by 70 years of age....

issues in oncology

Medicaid or No Insurance Associated With Worse Cancer-Specific Survival in Nonelderly Patients

In a study reported in the Journal of Clinical Oncology, Walker et al found that among nonelderly patients with the top 10 most lethal cancers, those with Medicaid or no insurance were more likely to present with advanced disease and less likely to receive cancer-directed surgery or radiation...

colorectal cancer
issues in oncology

Large Differences in Survival According to Hospital Risk-Adjusted Margin Positivity Rate Status in Rectal Cancer Surgery

Risk-adjusted margin positivity rate has been suggested for use as a rectal cancer surgery quality metric. In an observational cohort study reported in the Journal of Clinical Oncology, Massarweh et al from The University of Texas MD Anderson Cancer Center identified risk-adjusted margin positivity ...

breast cancer
issues in oncology
issues in oncology

Increases Seen in Use of Digital Mammography and Related Screening Costs in Medicare Population, but No Increase in Early Detection

In a study of use of breast cancer screening modalities in the Medicare population reported in the Journal of the National Cancer Institute, Killelea et al found significant increases in use of digital image acquisition and computer-aided detection and cost of screening, but no increase in rate of...

head and neck cancer
issues in oncology

Combined BRAF V600E and TERT Promoter Mutations Identify Aggressive and Recurrent Papillary Thyroid Cancer

In a study reported in Journal of Clinical Oncology, Xing et al found that the combined presence of BRAF V600E and TERT C228T mutations was associated with increased risk of recurrence and poor disease-free survival in patients with papillary thyroid cancer. The retrospective study included 365...

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