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issues in oncology
head and neck cancer

Lymph Nodes Signal More Aggressive Thyroid Cancer, Even in Young Patients

Patients older than age 45 with thyroid cancer that has spread to neck lymph nodes have long been considered at higher risk of dying, but the same has not been true for younger patients. Now researchers at the Duke Cancer Institute and the Duke Clinical Research Institute have found that...

head and neck cancer

ASCO 2015: Elective Neck Dissection Improves Early Oral Cancer Survival

A randomized phase III study resolves long-standing questions about the optimal timing of neck lymph node surgery for patients with early-stage oral cancer by showing that elective neck dissection both improves survival and lowers recurrence rates compared to therapeutic neck dissection performed...

head and neck cancer

ASCO 2015: Pembrolizumab Produces Clinically Meaningful Response in Patients With Recurrent or Metastatic Head and Neck Cancer

Immunotherapy with pembrolizumab (Keytruda) produced a clinically meaningful overall response rate in a study among 132 patients with recurrent or metastatic squamous cell carcinoma of the head and neck. The overall objective response rate was 24.8%, and 57% of patients experienced some tumor...

gynecologic cancers
solid tumors
gynecologic cancers
head and neck cancer
issues in oncology

Nine-Valent HPV Vaccine Protects Against 80% of Cervical Cancers

The new nine-valent human papillomavirus (HPV) vaccine (Gardasil 9) can potentially prevent 80% of cervical cancers in the United States, if given to all 11- or 12-year-old children before they are exposed to the virus. Additionally, the new vaccine, which includes seven cancer-causing...

gynecologic cancers
head and neck cancer
issues in oncology

AACR 2015: HPV Vaccine Provides Protection at Multiple Sites, Even Among Some Previously Exposed Patients

Vaccination of women aged 18 to 25 with the human papillomavirus (HPV) vaccine resulted in strong protection against future infection at three anatomic sites among women without prior HPV exposure and may still offer some protection in those with evidence of prior exposure. These findings were...

gynecologic cancers
head and neck cancer
issues in oncology
cost of care

Increasing Number of Boys Vaccinated Against HPV Could Protect More People at the Same Price

Public health programs that devote a portion of their funding to encourage more boys to be vaccinated against human papillomavirus (HPV)—rather than merely attempting to raise coverage among girls—may ultimately protect more people for the same price, a study from Duke University...

head and neck cancer

Erythropoietin Plus Radiation Therapy Does Not Improve Local-Regional Control in Anemic Patients With Head and Neck Cancer

Long-term analysis of Radiation Therapy Oncology Group (RTOG) 9903 demonstrates that the addition of erythropoietin did not improve local-regional control for anemic patients with head and neck squamous cell carcinoma who receive radiation therapy or chemoradiation, according to a study published...

head and neck cancer
issues in oncology

Effect of Smoking and Alcohol Consumption on Feeding Tube Duration in Head and Neck Cancer Patients

Current smoking and heavy alcohol consumption appear to be risk factors for prolonged use of a gastrostomy tube in patients with head and neck cancer undergoing radiotherapy or chemoradiotherapy. The findings were published in a report by O’Shea et al in JAMA Otolaryngology-Head & Neck...

breast cancer
head and neck cancer

New Analysis Reports Increased Risk of Thyroid Cancer After Breast Cancer Diagnosis

Breast cancer survivors are at increased risk of developing thyroid cancer, especially within 5 years of their breast cancer diagnosis, according to a new analysis of a large national database. The study results were presented at the Endocrine Society's 97th Annual Meeting. “Recognition of...

head and neck cancer

FDA Approves Lenvatinib for Progressive Radioiodine-Refractory Differentiated Thyroid Cancer

The U.S. Food and Drug Administration (FDA) today granted approval to lenvatinib (Lenvima) to treat patients with progressive, differentiated thyroid cancer whose disease progressed despite receiving radioactive iodine therapy. Lenvatinib is a tyrosine kinase inhibitor that binds to multiple sites...

head and neck cancer

Lenvatinib Shows Promise for Patients With Radioiodine-Refractory Thyroid Cancer in Phase III Study

In a phase III study led by researchers at The University of Texas MD Anderson Cancer Center, the oral antiangiogenic therapy lenvatinib has shown dramatic improvement in progression-free survival in patients with advanced radioiodine-refractory thyroid cancer. Their findings are published by...

head and neck cancer
issues in oncology

Study Uncovers Range of Molecular Alterations in Head and Neck Squamous Cell Carcinomas, New Potential Drug Targets

Investigators with The Cancer Genome Atlas (TCGA) Research Network have discovered genomic differences—with potentially important clinical implications—in human papillomavirus (HPV)-associated head and neck cancers. These findings were reported in Nature. The researchers also uncovered ...

head and neck cancer
issues in oncology

Head and Neck Cancers in Young Adults More Likely to Be a Result of Inherited Factors

Data from 25 case-control studies and separate analyses show that head and neck cancers in young adults are more likely to occur as a result of inherited factors rather than lifestyle factors, such as smoking or drinking alcohol, according to a new study by Toporcov et al published in the...

head and neck cancer

Oral Human Papillomavirus Infection More Likely to Persist in Older Men

Oral infection with human papillomavirus 16 (HPV16), which is the type of HPV most frequently linked to HPV-driven head and neck cancers, was more likely to persist 12 or more months in men older than 45 than in those younger than 45, according to a study reported by Pierce Campbell et al in...

head and neck cancer

FDA Grants Lenvatinib Priority Review Designation for Advanced Thyroid Cancer

The U.S. Food and Drug Administration (FDA) has accepted for review the New Drug Application for lenvatinib mesylate as a treatment for progressive radioactive iodine–refractory differentiated thyroid cancer and granted the application Priority Review status. Lenvatinib is an oral multiple...

head and neck cancer
issues in oncology

Study Finds Potential Link Between BRCA1/2 Mutations and Salivary Gland Cancer

The risk of developing cancer in a salivary gland might be higher in people with BRCA1 or BRCA2 mutations, which are associated with breast and ovarian cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital...

head and neck cancer

Lymphatic Mapping Agent Receives Orphan Drug Designation for Head and Neck Cancers

Navidea Biopharmaceuticals, Inc, recently announced that technetium 99m tilmanocept (Lymphoseek Injection) has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for use in sentinel lymph node detection in patients with cancer of the head and neck. The designation...

head and neck cancer

Blood and Saliva Tests Help Predict Recurrence of HPV-Related Oral Cancer

Physicians at Johns Hopkins have developed blood and saliva tests that help accurately predict recurrences of HPV-linked oral cancers in a substantial number of patients. The tests screen for DNA fragments of the human papillomavirus (HPV) shed from cancer cells lingering in the mouth or other...

head and neck cancer
issues in oncology

Researchers Identify Genetic Mutations Linked to Salivary Gland Tumors

Research conducted at the Florida campus of The Scripps Research Institute (TSRI) has discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that...

head and neck cancer

New Molecular Test Increases Odds of Correct Surgery for Thyroid Cancer Patients

The routine use of a molecular testing panel developed at the University of Pittsburgh Medical Center greatly increases the likelihood of performing the correct initial surgery for patients with thyroid nodules and cancer, reported researchers from the University of Pittsburgh Cancer Institute. The ...

head and neck cancer

Antipain Agent Shrinks Oral Cancers, Sparing Healthy Tissue

Mouse models of human oral cancer treated with an agent called capsazepine showed dramatic tumor shrinkage without damage to surrounding tissues, researchers from the School of Dentistry and School of Medicine at The University of Texas Health Science Center at San Antonio found. The findings by...

head and neck cancer

FDA Approves Radioactive Diagnostic Imaging Agent to Help Determine the Extent of Head and Neck Cancer in the Body

The U.S. Food and Drug Administration today approved a new use for technetium 99m tilmanocept (Lymphoseek Injection), a radioactive diagnostic imaging agent used to help doctors determine the extent to which squamous cell carcinoma has spread in the body’s head and neck region. In 2013,...

head and neck cancer

Hyperfractionated Radiation Therapy Improves Local-Regional Control Without Increasing Late Toxicity in Locally Advanced Head and Neck Cancer

Patients with locally advanced squamous cell carcinoma of the head and neck treated with hyperfractionated radiation therapy experienced improved local-regional control and, with patients censored at 5 years, improved overall survival with no increase in late toxicity, according to a study...

head and neck cancer

Study Examines Protein Expression Biomarkers in HPV-Negative Squamous Cell Carcinomas of the Head and Neck

A quartet of proteins that play critical roles in cell replication, cell death, and DNA repair could lead to better targets for therapy against treatment-resistant head and neck squamous cell cancers. In a study presented this week at the American Association for Cancer Research (AACR) Annual...

head and neck cancer

Prognosis of HPV-Positive Head and Neck Cancer Varies According to Tumor Site

Patients with cancer of the throat and who are positive for the human papillomavirus (HPV) have a good prognosis, but until now the effect of being HPV-positive on the prognosis of tumors located elsewhere in the head and neck was unknown. A new study presented at the 33rd Conference of the...

head and neck cancer

Oropharyngeal Cancer Patients Report Benefit in Salivary Function With Reduction of Radiation Dose to Bilateral Submandibular Lymph Nodes

For head and neck cancer patients undergoing radiation therapy, a reduction in the amount of radiation treatment volume to the submandibular (level IB) lymph nodes resulted in better patient-reported salivary function, according to research presented today at the 2014 Multidisciplinary Head and...

head and neck cancer

Patients With Oropharyngeal Cancer Report Decreased Quality of Voice and Speech After Treatment

Patients with oropharyngeal cancer treated with combined chemotherapy and radiation therapy reported a decrease in their voice and speech quality for up to 1 year after the completion of treatment, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium....

head and neck cancer

Distant Metastases Occur Later and in More Subsites in Patients With HPV-Positive Squamous Cell Carcinoma of the Oropharynx

Patients with human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx had a longer time to development of distant metastasis after initial treatment, and had more metastatic sites in more atypical locations compared to HPV-negative patients, according to research presented...

head and neck cancer

HPV-Positive Oropharyngeal Cancer Associated With Higher Overall Survival Rate After Progression Than HPV-Negative Disease

A retrospective analysis of patients with oropharyngeal cancer with recurrence of disease after primary therapy in the Radiation Therapy Oncology Group (RTOG) studies 0129 and 0522 found that human papillomavirus (HPV)-positive patients had a higher overall survival rate than HPV-negative patients, ...

head and neck cancer

Obesity Linked to Poor Survival in Patients With Tongue Cancer

Cancer experts from Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College are collaborating to understand the link between obesity and cancer. Most recently, their research has yielded an interesting association: Obesity prior to diagnosis is associated with a fivefold increase...

head and neck cancer

Intensity-Modulated Radiation Therapy Improves Survival in Patients With Head and Neck Cancer

Patients with cancers of the head and neck who received intensity-modulated radiation therapy experienced improved outcomes, as well as reduced toxicities, compared to patients receiving conventional radiation therapy, according to findings published online in Cancer by Beadle et al. The study is...

head and neck cancer
issues in oncology

U.S. Preventive Services Task Force Issues Final Recommendations on Screening for Oral Cancer

The U.S. Preventive Services Task Force (USPSTF) today released its final recommendation statement on screening for oral cancer in adults without signs or symptoms of oral cancer who are seen by primary care providers. This recommendation focuses on primary care professionals and is not a...

head and neck cancer

Certain Symptom Clusters After Surgery for Esophageal Cancer Predict Poor Prognosis

A new study has found that several months after surgery for esophageal cancer, different symptoms cluster together in different types of patients. In addition, patients with certain symptom clusters have an increased risk of dying from their disease. The findings by Wikman et al were published...

head and neck cancer

FDA Approves Sorafenib to Treat Late-Stage Differentiated Thyroid Cancer

The U.S. Food and Drug Administration today expanded the approved uses of sorafenib (Nexavar) to treat late-stage differentiated thyroid cancer. The new indication is for patients with locally recurrent or metastatic, progressive differentiated thyroid cancer that no longer responds to radioactive...

head and neck cancer

Smoking Increases Risk of Death for Nasopharyngeal Carcinoma Survivors

Survivors of nasopharyngeal carcinoma who are former or current smokers are more likely to have their disease progress, relapse, or spread, and are more likely to die of their disease, compared with survivors of nasopharyngeal carcinoma who have never smoked, according to a study published in...

head and neck cancer

ASTRO: Intensity Modulated Proton Therapy May Preserve Quality of Life in Patients With Oropharyngeal Cancer

A new study from researchers at The University of Texas MD Anderson Proton Therapy Center found that the use of feeding tubes in patients with oropharyngeal cancer treated with intensity modulated proton therapy decreased by more than 50% compared to patients treated with intensity modulated...

head and neck cancer
supportive care

Swallowing Exercises Preserve Function in Patients Receiving Radiation for Head and Neck Cancer

A study from UCLA's Jonsson Comprehensive Cancer Center (JCCC) has found that patients with head and neck cancer receiving radiation as part of their treatment were less likely to suffer unwanted side effects such as worsening of diet, need for a feeding tube, or narrowing of the throat passage if...

head and neck cancer

Sorafenib Granted Priority Review for Differentiated Thyroid Cancer

Bayer HealthCare and Onyx Pharmaceuticals announced that the FDA has granted priority review designation to the supplemental new drug application of sorafenib (Nexavar) tablets for the treatment of locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer. The...

skin cancer
head and neck cancer

Omega-3 Fatty Acids May Aid in Treatment and Prevention of Skin and Oral Cancers

Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early- and late-stage oral and skin squamous cell carcinomas, according to new research from scientists at Queen Mary, University of London. The findings were published online...

gynecologic cancers
head and neck cancer
issues in oncology

HPV Vaccine Reduces Prevalence of Oral HPV Infections in Costa Rican Study

A new study by the International Agency for Research on Cancer (IARC), in partnership with Costa Rican investigators and the National Cancer Institute (NCI), shows for the first time that the vaccine against human papillomavirus (HPV) types 16 and 18, which is used to prevent cervical cancer, also...

head and neck cancer

Single Men, Smokers at Higher Risk for Oral HPV Infection

Smokers and single men are more likely to acquire oncogenic oral human papillomavirus (HPV), according to new results from the HPV Infection in Men (HIM) Study. Researchers from Moffitt Cancer Center, the National Cancer Institute, Mexico, and Brazil also reported that newly acquired oral HPV...

head and neck cancer

Increasing Incidence of Papillary Thyroid Cancer Linked to Overdiagnosis

The rapid increase in papillary thyroid cancer in the United States may not be linked to increase in occurrence, but instead may be linked to an increase in the diagnosis of precancerous conditions and to a person's insurance status, according to a study published online in Thyroid. "This [study]...

issues in oncology
head and neck cancer

Investigators Identify Promising Biomarker for Predicting HPV-related Oropharyngeal Cancer

Researchers have found that antibodies against the human papillomavirus (HPV) may help identify individuals who are at greatly increased risk of HPV-related cancer of the oropharynx, In their study, at least one in three individuals with oropharyngeal cancer had antibodies to HPV, compared to...

head and neck cancer
head and neck cancer

ASCO 2013: Sorafenib Stalls Growth of Treatment-resistant Differentiated Thyroid Cancer

A randomized phase III study found that the targeted drug sorafenib (Nexavar) stalls disease progression by 5 months in patients with metastatic differentiated thyroid cancer that has progressed despite standard radioactive iodine therapy. If approved in this setting by the U.S. Food and Drug...

gynecologic cancers
head and neck cancer

ASCO 2013: No Increased Risk of Oral HPV Infections Reported in Long-term Partners of Patients with HPV-positive Oropharyngeal Cancers

Spouses and long-term partners of patients diagnosed with human papillomavirus (HPV)-positive oropharyngeal cancer were no more likely to test positive for oral HPV infection than people in the general population and have a low risk of HPV-related oropharyngeal cancer, according to the Human Oral...

head and neck cancer

FDA Grants Fast Track Designation to SGX942 for the Treatment of Oral Mucositis

The FDA has granted fast track designation to the SGX942 development program for the treatment of oral mucositis as a result of radiation and/or chemotherapy treatment in patients with head and neck cancer. SGX942 is a fully synthetic, 5-amino acid peptide with high aqueous solubility and...

head and neck cancer
issues in oncology

Frequent Heartburn May Predict Cancers of the Throat and Vocal Cord

Frequent heartburn was positively associated with cancers of the throat and vocal cord among nonsmokers and nondrinkers, and the use of antacids, but not prescription medications, had a protective effect, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of...

head and neck cancer

Genetic Diversity Predicts Outcomes in Head and Neck Cancer

A new measure of the heterogeneity of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer.  In the May 20 issue of the journal Cancer, investigators at Massachusetts General Hospital (MGH) and Massachusetts Eye and Ear...

head and neck cancer

Chernobyl Follow-up Study Finds High Survival Rate among Young Thyroid Cancer Patients

More than a quarter of a century after the Chernobyl nuclear disaster, many children and teenagers who developed thyroid cancer due to radiation are in complete or near remission, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology ...

head and neck cancer

Study to Treat Deadly Form of Thyroid Cancer Shows Promise, Mayo Clinic Says

A combination of therapies may prove to be a promising advance for the treatment of anaplastic thyroid cancer based on results of a phase I clinical trial, said researchers at Mayo Clinic in Florida. Anaplastic thyroid cancer is one of the deadliest of all cancers. Nearly all patients diagnosed...

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