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Your search for Matthew Stenger matches 81 pages

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issues in oncology
supportive care

Patient Perceptions of Management of Cancer-Related Pain, Fatigue, and Emotional Distress in Community Oncology Centers

In a study reported in the Journal of Clinical Oncology, Smith et al found that a high proportion of patients in community cancer centers did not report discussing, getting advice, or receiving desired help for cancer-related pain, fatigue, or emotional distress. The study involved surveys of...

supportive care

CALM Psychotherapeutic Intervention Reduces Depression in Patients With Advanced Cancer

In a study reported in the Journal of Clinical Oncology, Rodin et al found that a manualized psychotherapeutic intervention (Managing Cancer and Living Meaningfully, CALM) was successful in reducing depressive symptoms in patients with advanced cancer. CALM is novel, brief, tailored...

solid tumors
supportive care

Prognostic Model for Malignant Pleural Effusion

As reported in The Lancet Oncology, Psallidas et al developed a model that is predictive of 3-month survival in patients with malignant pleural effusion. Study Details The PROMISE study involved an analysis of 5 independent data sets from randomized trials to discover, validate, and prospectively ...

supportive care

Predictors of Posthospital Care Transitions in Advanced Cancer

In a study reported in the Journal of Clinical Oncology, Lage and colleagues found that among patients with advanced cancer who had an unplanned hospital admission, those discharged to hospice or post–acute care facilities had a worse symptom burden and physical function and worse survival...

supportive care

Sperm Banking for Adolescent Males With Newly Diagnosed Cancer

In a study reported in the Journal of Clinical Oncology, Klosky et al identified factors associated with sperm banking among adolescent males with newly diagnosed cancer who were at increased risk for treatment-related fertility loss. The study included 146 adolescents aged 13 to 22 years (mean...

supportive care
symptom management

Olanzapine Combination Reduces Nausea and Vomiting in Patients Receiving Highly Emetogenic Chemotherapy

In a phase III trial reported by Navari et al in The New England Journal of Medicine, the addition of the antipsychotic agent olanzapine vs placebo to dexamethasone, aprepitant, or fosaprepitant, and a 5-hydroxytryptamine type 3–receptor antagonist reduced nausea and improved antiemetic...

supportive care
symptom management

Impact of Systemic Inflammation on Quality of Life in Advanced Cancer

In a study reported in the Journal of Clinical Oncology, Laird et al found that increased systemic inflammation was associated with poorer patient-reported quality of life independent of performance status. Study Details The study involved data from 2,520 adult patients in a biobank of patients...

supportive care

Family-Focused Therapy Continued Into Bereavement Benefits High-Risk Families

Family-focused grief therapy continued into bereavement reduced the severity of complicated grief and the risk of prolonged grief disorder among high-risk families of dying cancer patients, according to a report by Kissane et in the Journal of Clinical Oncology. Study Details In the trial,...

supportive care

Cancer and Fertility Program Improves Patient Satisfaction With Information on Fertility Risks and Preservation

A cancer and fertility program established at Memorial Sloan Kettering Cancer Center (MSKCC) improves patient satisfaction with information received regarding fertility risks and preservation options, according to a report by Kelvin et al in the Journal of Clinical Oncology. Designed to support...

breast cancer
supportive care

Epoetin Alfa vs Best Standard of Care in Treatment of Anemia in Patients With Metastatic Breast Cancer Receiving Chemotherapy

Use of epoetin alfa (Epogen, Procrit) vs best standard of care to treat anemia did not achieve noninferiority for investigator-assessed progression-free survival in patients receiving chemotherapy for metastatic breast cancer, reported Leyland-Jones et al in the Journal of Clinical Oncology....

gynecologic cancers
supportive care
symptom management

Fosaprepitant Combination Reduces Risk of Emesis During Chemoradiotherapy for Cervical Cancer

The addition of fosaprepitant (Emend) to palonosetron and dexamethasone reduced the risk of emesis during 5 weeks of chemoradiotherapy for cervical cancer, according to the phase III GAND-emesis trial reported in The Lancet Oncology by Ruhlmann et al. Study Details In the double-blind trial, 234...

supportive care
issues in oncology

UK Trial Shows Little Benefit of Pregabalin Combined With Palliative Radiotherapy for Cancer-Induced Bone Pain

In a UK study reported in the Journal of Clinical Oncology, Fallon et al found no improvement with pregabalin vs placebo combined with concurrent palliative radiotherapy in relieving cancer-induced bone pain. Study Details In the double-blind trial, 233 patients with bone metastases who were...

breast cancer
supportive care
survivorship

Risk Factors for Lymphedema in Patients Treated for Breast Cancer

In a study reported in the Journal of Clinical Oncology, Ferguson et al found that cellulitis in the affected arm, but not blood draws, injections, trauma to the affected arm, or air travel, was associated with an increased risk of lymphedema in women treated for breast cancer. Study Details In...

breast cancer
supportive care

No Association Seen Between New or Worsening Aromatase Inhibitor–Related Musculoskeletal or Vasomotor Symptoms and Relapse-Free Survival

Retrospective analyses of the ATAC, TEAM, and BIG 1-98 adjuvant endocrine therapy trials in breast cancer have suggested that treatment-emergent endocrine symptoms may be associated with superior survival outcomes. However, in a study reported in the Journal of Clinical Oncology, Stearns et al...

breast cancer
supportive care

Telephone and In-Person Counseling for Weight Loss Effective in Women Treated for Breast Cancer

In the LEAN (Lifestyle, Exercise, and Nutrition) study reported in the Journal of Clinical Oncology, Harrigan et al found that telephone and in-person weight loss counseling was effective in reducing weight and C-reactive protein level in overweight or obese women treated for breast cancer. In the ...

palliative care
supportive care
issues in oncology

Italian Study Shows Low-Dose Morphine Better Than Weak Opioids in Relieving Moderate Cancer Pain

In an Italian trial reported in the Journal of Clinical Oncology, Bandieri et al found that low-dose morphine provided better and more rapid pain relief than weak opioids in patients with moderate cancer pain. Study Details In the open-label 28-day trial, 240 adults with moderate cancer pain from ...

supportive care
issues in oncology
issues in oncology

Electronic Symptom Self-Reporting During Cancer Treatment May Be Associated With Better Quality of Life and Other Clinical Benefits

As reported in the Journal of Clinical Oncology by Basch et al, a trial conducted among patients receiving routine outpatient chemotherapy for advanced solid tumors at Memorial Sloan Kettering Cancer Center indicated that patient use of tablet computers to report common symptoms was associated with ...

breast cancer
supportive care

Chemotherapy-Induced Peripheral Neuropathy May Be Associated With Cerebral Perfusion and Gray Matter Changes

In a study reported in the Journal of Clinical Oncology, Nudelman et al found that increased chemotherapy-induced peripheral neuropathy symptoms at 1 month after completing treatment for breast cancer was associated with increased cerebral perfusion and increased gray matter density at 1 month....

supportive care
issues in oncology

Dexamethasone Reduces Pain Flare After Palliative Radiotherapy for Bone Metastases

In a Canadian phase III trial reported in The Lancet Oncology, Chow et al found that prophylactic dexamethasone reduced the incidence of radiation-induced pain flare compared with placebo in patients receiving palliative radiotherapy for bone metastases. Study Details In this double-blind trial,...

prostate cancer
supportive care

Similar Pain Outcome With Ibandronate vs Single-Dose Radiotherapy for Localized Metastatic Bone Pain in Prostate Cancer

In a UK phase III noninferiority trial reported in the Journal of the National Cancer Institute, Hoskin et al found similar effects of single-dose ibandronate and single-dose radiotherapy on localized metastatic bone pain in patients with prostate cancer. Study Details In the open-label trial,...

breast cancer
supportive care
survivorship
issues in oncology

Sham and Real Electroacupuncture Reduce Hot Flashes vs Gabapentin and Pill Placebo in Breast Cancer Survivors

In a study assessing placebo effects reported in the Journal of Clinical Oncology, Mao et al found that sham electroacupuncture produced a greater reduction in hot flashes than placebo pills and gabapentin, with the greatest reduction being achieved with real electroacupuncture. Study Details In...

supportive care
issues in oncology

Rolapitant Reduced Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Highly Emetogenic Cisplatin-Based Chemotherapy

In two phase III trials reported in The Lancet Oncology, Rapoport et al found that the addition of rolapitant to serotonin (5-HT3) receptor antagonist and dexamethasone treatment significantly improved complete response rates in prevention of chemotherapy-induced nausea and vomiting in patients...

supportive care
issues in oncology

Rolapitant Reduced Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Moderately Emetogenic Chemotherapy or Anthracycline/Cyclophosphamide

In a phase III study reported in The Lancet Oncology, Schwartzberg et al found that the addition of rolapitant to serotonin (5-HT3) receptor antagonist and dexamethasone treatment significantly improved complete response rates in prevention of chemotherapy-induced nausea and vomiting in patients...

supportive care

ASCO Clinical Practice Guideline Update: Recommendations for Using White Blood Cell Growth Factors

ASCO has issued a clinical practice guideline update on the use of hematopoietic colony-stimulating factors, as reported in the Journal of Clinical Oncology by Smith et al. This update to the ASCO 2006 guideline was based on a systematic review of randomized clinical trials, meta-analyses, and ...

supportive care

German Study Shows Urea Cream Better Than Antioxidant Ointment in Preventing Capecitabine-Associated Hand-Foot Syndrome

In a phase III study reported in the Journal of Clinical Oncology, Hofheinz et al found that 10% urea cream was better at preventing capecitabine-related hand-foot syndrome than a new ointment (Mapisal) available in Germany that contains several antioxidants and exhibits high radical protection....

supportive care
cost of care

Earlier Palliative Care Consultation Associated With Cost Savings

In a prospective cohort study reported in the Journal of Clinical Oncology, May et al found that earlier palliative care consultation for inpatients with advanced cancer was associated with lower total direct costs. Study Details The study included 969 patients with advanced cancer admitted to 5...

supportive care
issues in oncology

Need for Mental Health Services for Parents Who Lose a Child to Cancer

In a study reported in the Journal of Clinical Oncology, Lichtenthal et al found that parents who have lost a child to cancer report wanting and frequently using mental health services, although barriers to seeking care exist and retention in care is suboptimal. Study Details The cross-sectional...

breast cancer
supportive care
issues in oncology

Omega-3 Fatty Acids and Placebo Reduce Aromatase Inhibitor–Related Musculoskeletal Pain in Early Breast Cancer

In the SWOG S0927 trial reported in the Journal of Clinical Oncology, Hershman et al found that both omega-3 fatty acids and placebo resulted in marked persistent reductions in aromatase inhibitor–related arthralgia among patients with early breast cancer, with no difference between...

palliative care
pancreatic cancer
supportive care

German Trial Shows Reduced Risk of Venous Thromboembolism With Prophylactic Enoxaparin in Ambulatory Patients With Advanced Pancreatic Cancer

In the German CONKO-004 trial reported in the Journal of Clinical Oncology, Pelzer et al found that prophylactic treatment with the low-molecular-weight heparin enoxaparin reduced the risk of symptomatic venous thromboembolic events in ambulatory patients receiving first-line chemotherapy for...

cns cancers
supportive care

Donepezil Provides Modest Improvement in Cognitive Function Domains in Irradiated Brain Tumor Survivors

In a phase III trial reported in the Journal of Clinical Oncology, Rapp et al found that the neurotransmitter modulator donepezil may modestly improve some cognitive function domains in patients undergoing cranial irradiation for brain tumors. Improvements were greater in patients with greater...

supportive care
issues in oncology

No Differences in Patient-Reported Outcomes or Resource Use With Early vs Delayed Initiation of Palliative Care Intervention

In the ENABLE III study reported in the Journal of Clinical Oncology, Bakitas et al found that early vs delayed initiation of a palliative care intervention did not result in improved patient-reported outcomes or resource use. Early initiation was associated with better 1-year survival. Study...

supportive care
issues in oncology

Reduced Family Caregiver Depression With Early vs Delayed Palliative Care Intervention for Caregivers

In the ENABLE III study reported in the Journal of Clinical Oncology, Dionne-Odom et al found that early vs delayed use of a palliative care intervention for family caregivers of patients with advanced cancer reduced caregiver depression scores and caregiver stress burden. No differences in...

supportive care

Addition of Aprepitant to Ondansetron Effective in Preventing Chemotherapy-Induced Nausea and Vomiting in Pediatric Patients

In a phase III trial reported in The Lancet Oncology, Kang et al found that adding aprepitant to ondansetron with or without dexamethasone was effective in preventing chemotherapy-induced nausea and vomiting in pediatric patients receiving moderately or highly emetogenic chemotherapy. Study...

pancreatic cancer
supportive care
palliative care

Palliative Care Consultation Associated With Less Aggressive End-of-Life Care in Advanced Pancreas Cancer

In a study reported in the Journal of the National Cancer Institute, Jang et al found that palliative care consultation was associated with decreased use of chemotherapy near death and lower risks of ICU admission, multiple emergency department visits, and multiple hospitalizations near death in...

hepatobiliary cancer
supportive care

Urea-Based Cream Prevents Sorafenib-Associated Hand-Foot Skin Reactions in Chinese Patients With Advanced Hepatocellular Carcinoma

In a Chinese study reported in the Journal of Clinical Oncology, Ren et al found that prophylactic use of urea-based cream reduced the incidence of sorafenib (Nexavar)–associated hand-foot skin reactions in patients with advanced hepatocellular carcinoma. Urea-based creams are used to treat...

palliative care
supportive care

Meaning-Centered Group Psychotherapy Improves Psychological Well-Being in Patients With Advanced Cancer

In a randomized trial reported in the Journal of Clinical Oncology, Breitbart et al found that meaning-centered group psychotherapy significantly improved psychological well-being compared with supportive group psychotherapy in patients with advanced or terminal cancer. Meaning-centered group...

supportive care

ASCO Clinical Practice Guideline Update 2014: No Change to 2013 Venous Thromboembolism Prophylaxis and Treatment Guideline

As reported in the Journal of Clinical Oncology by Lyman et al, an ASCO update committee recommended no changes to the 2013 clinical practice guideline for venous thromboembolism (VTE) prophylaxis and treatment after review of 53 new publications in the area that became available between...

supportive care

Anamorelin Increases Lean Body Mass in Patients With Cancer Cachexia

In an integrated analysis of two phase II trials reported in The Lancet Oncology, Garcia et al found that treatment with anamorelin, an oral ghrelin-receptor agonist with appetite-enhancing and anabolic activity, produced a gain in lean body mass in patients with cancer anorexia-cachexia syndrome. ...

supportive care
issues in oncology

Cognitive Behavioral Therapy Improves Insomnia After Cancer Treatment With No Difference in Combination With Placebo or Armodafinil

In a study reported in Journal of Clinical Oncology, Roscoe et al found that cognitive behavioral therapy combined with placebo or the wakefulness-promoting agent armodafinil (Nuvigil) had similar beneficial effects on insomnia and sleep quality in cancer survivors. Study Details In the study, 96 ...

supportive care
issues in oncology

Management of Cancer Pain Has Improved but Remains Inadequate

In a study reported in the Journal of Clinical Oncology, Greco et al updated a 2008 systematic review on cancer pain management. Improvements were seen between 2008 and 2013, but approximately one-third of patients still do not receive pain medication adequate for reported pain intensity. Changes...

breast cancer
supportive care

Exercise Improves Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors

In the HOPE study reported in the Journal of Clinical Oncology, Irwin et al found that a program of aerobic exercise and strength training produced significant improvement in aromatase inhibitor–associated arthralgia in breast cancer survivors. Study Details In the study, 121 women with...

supportive care
issues in oncology

Absence of Residual Thrombosis After 6 Months of Low–Molecular Weight Heparin Indicates Low Risk for Recurrent Cancer-Related Deep-Vein Thrombosis

In an Italian study (Cancer-DACUS) reported in the Journal of Clinical Oncology, Napolitano et al found that patients with no residual vein thrombosis after 6 months of low–molecular weight heparin for a first episode of cancer-related deep-vein thrombosis of the lower limbs had low risk for...

supportive care

Oral Rivaroxaban Has Efficacy Similar to Enoxaparin Plus Vitamin K Antagonist in Preventing Recurrent Venous Thromboembolism

In a subgroup analysis of the pooled results of the EINSTEIN-DVT and EINSTEIN-PE trials reported in The Lancet Haematology, Prins et al found that the recurrence rate for venous thromboembolism in cancer patients receiving anticoagulant therapy with oral rivaroxaban (Xarelto) was similar to that in ...

supportive care
issues in oncology

Adding Aprepitant to Granisetron/Dexamethasone Reduces Chemotherapy-Induced Nausea and Vomiting After High-Dose Melphalan Conditioning in Myeloma

In a phase III trial reported in the Journal of Clinical Oncology, Schmitt et al found that adding aprepitant to granisetron and dexamethasone significantly reduced chemotherapy-induced nausea and vomiting in myeloma patients undergoing high-dose melphalan conditioning and autologous stem cell...

supportive care

African Americans More Likely Than Whites to Receive Analgesic With Toxic Metabolite for Cancer Pain

A study reported by Meghani et al in the Journal of Clinical Oncology showed that African American patients with cancer pain are more likely than white patients to receive morphine, with its known 3- and 6-glucuronide neurotoxic metabolites, despite their higher reported risk for chronic kidney...

supportive care
issues in oncology

Corticosteroids Improve Fatigue, Appetite Loss, and Patient Satisfaction but Not Pain in Opioid-Treated Advanced Cancer Patients, Small Study Shows

In a small Norwegian study reported in the Journal of Clinical Oncology, Paulsen et al found that methylprednisolone treatment improved fatigue, appetite loss, and patient satisfaction but not pain in patients with advanced cancer receiving opioid treatment for pain. Study Details In the study,...

supportive care
survivorship

No Clinical Outcome Benefit With Aerobic Training Program in Cancer Patients With Heart Failure

In a retrospective analysis in the HF-ACTION trial reported in the Journal of Clinical Oncology, Jones et al found that a program of aerobic training did not reduce the rate of all-cause mortality or hospitalization in cancer patients with heart failure. Some evidence suggested that patients who...

supportive care

Long-Term Central Venous Catheter Use Associated With Three- to Sixfold Increased Risk of Infection in Older Patients With Cancer

In a retrospective SEER (Surveillance, Epidemiology, and End Results)/Medicare data analysis reported in the Journal of Clinical Oncology, Lipitz-Snyderman et al found that long-term central venous catheter use was associated with a three- to sixfold increase in risk of infection in older...

breast cancer
supportive care

HERA Trial 8-Year Follow-up Shows Low Rate of Trastuzumab-Associated Cardiac Dysfunction

In a study reported in Journal of Clinical Oncology, Azambuja et al found low rates of trastuzumab (Herceptin)-related cardiac dysfunction over a median of 8 years of follow-up in the HERceptin Adjuvant (HERA) trial. The majority of patients with cardiac dysfunction achieved acute recovery. Study...

supportive care

MEK Inhibitor Use Associated With Bilateral Subfoveal Neurosensory Retinal Detachment

As reported in JAMA Ophthalmology, McCannel and colleagues identified three cases of subfoveal neurosensory retinal detachment among patients receiving MEK inhibitor therapy for metastatic cancer in clinical trials requiring ophthalmologic examination at their institution. In all cases, the toxic...

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