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Showing 101 - 150Nearly 20% of Patients With Ovarian Cancer Do Not Undergo Surgery
Nearly 20% of women with ovarian cancer do not undergo surgery, despite it being a standard part of treatment recommendations, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The findings, which suggest that women may live four times longer with...
New ASCO Cervical Cancer Guidelines Address Global Resource Disparities
On May 25, ASCO issued its first clinical practice guideline on invasive cervical cancer. This resource-stratified guideline is the first of its kind from ASCO, offering treatment recommendations tailored to resource availability. Access to cervical cancer care varies between regions of the...
Combining Two FDA-Approved Diagnostic Tests Increased Detection of High-Grade Cervicovaginal Lesions
Cytopathology researchers at Houston Methodist Hospital recently found that combining two diagnostic tests—the Papanicolau (Pap) and high-risk human papillomavirus (hrHPV)—dramatically decreased the chance of missing tumors and high-grade lesions by sevenfold. Zhou et al published...
AACR 2016: RAF-Targeted Therapeutic BGB-283 Shows Early Promise Against Tumors With BRAF and RAS Mutations
The new investigational anticancer therapeutic BGB-283, which targets the RAF family of proteins, was safe, tolerable, and showed signs of clinical activity in patients who had a range of types of cancer with mutations in BRAF, KRAS, and NRAS, according to results from a phase I clinical trial...
ASCO Urges Aggressive Efforts to Increase HPV Vaccination and Prevent Cancer
Use of human papillomavirus (HPV) vaccines should be rapidly expanded to protect thousands of young people in the United States—and millions worldwide—from life-threatening cancers, ASCO said April 11 in a policy statement. Published by Bailey et al in the Journal of Clinical Oncology,...
SGO 2016: Advanced Ovarian Cancer Caused by Genetic Mutations Linked to Better PFS and OS Following Treatment Including Bevacizumab
Women with advanced ovarian cancer caused by genetic mutations—including in BRCA1 and BRCA2—lived significantly longer than those who did not have a mutation following treatment with a chemotherapy regimen that included bevacizumab (Avastin). According to a study, those with BRCA1 and a ...
Sparing Ovaries and Removing Fallopian Tubes May Cut Cancer Risk, but Few Have Procedure
During hysterectomies for noncancerous conditions, removing both fallopian tubes while keeping the ovaries may help protect against ovarian cancer and preserve hormonal levels, but few women receive this surgical option, according to a new study by Yale School of Medicine researchers. Published by ...
100% of NCI-Designated Cancer Centers Endorse the Promotion of the HPV Vaccination for Cancer Prevention
All National Cancer Institute (NCI)-designated cancer centers have united to support human papillomavirus (HPV) vaccination. A team of HPV experts drafted a consensus statement that advises widespread use of HPV vaccines to prevent cancer. HPV causes cancer of the cervix, anus, and throat. The HPV ...
New NCCN Guidelines for Vulvar Cancer Available
The National Comprehensive Cancer Network (NCCN) has published new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for vulvar cancer; these NCCN Guidelines® are currently available as Version 1.2016. The NCCN Drugs & Biologics Compendium (NCCN Compendium®) has been...
New Method to Improve Preoperative Diagnosis of Ovarian Cancer Based on Ultrasound
In a landmark study, investigators from Europe proposed a new and simple method to assess the risk of malignancy of women with an adnexal mass. The method identified between 89% and 99% of patients with ovarian cancer using the results of ultrasound examination, which can be obtained in referral...
HPV Vaccine Uptake Is Highest Among Girls in High-Poverty and Majority Hispanic Communities
Adolescent girls living in high-poverty communities and majority Hispanic communities were more likely to have received at least one dose of a human papillomavirus (HPV) vaccine than those living in low-poverty communities and in communities of other racial and ethnic compositions. These findings...
Follow-up Times for Colorectal Cancer Screening Abnormalities Lag Behind Others
Follow-up times of abnormal screening exams were shorter for breast cancer than they were for colorectal and cervical cancers, according to a recent study involving more than 1 million individuals who underwent these screenings. Recently published by Tosteson et al in the Journal of General...
Access to Minimally Invasive Hysterectomies in Early Uterine Cancer Remains Persistently Limited
A new study led by Johns Hopkins researchers shows wide racial and economic disparities in access to minimally invasive hysterectomies for early uterine cancer in the United States. This is despite years of accumulating evidence that the procedures to remove the uterus are linked to fewer...
Study Identifies Ovarian Cancer Cell Hierarchy
Can any cancer cell form another tumor, or is it only select cancer stem cells that give rise to new cancer cells? The answer, a new study finds, is both. Researchers at the University of Michigan Comprehensive Cancer Center looked at human ovarian cancer cells, and found that, for the most part,...
Risk of Undetected Cancer in Gynecologic Surgery Higher Than Previously Thought
Minimally invasive gynecologic surgeries have advantages for patients, including shorter hospital stays, quicker recoveries, and less pain. However, power morcellation, a technique that cuts the uterus or fibroid into small pieces in order to extract them from the abdomen through a small incision,...
Researchers Find Experimental Drug Reduces Ascites With Minimal Side Effects in Preclinical Studies
Women who have ovarian cancer often develop a condition called ascites, which is a buildup of fluids in the abdomen. The most common treatment for ascites is puncturing the abdomen and manually draining the fluid, which is painful, risky, and must be repeated every few weeks. University of...
Healthy Diet May Reduce Risk of Ovarian Cancer in African American Women
A healthy diet may reduce the risk of ovarian cancer in African American women, according to data presented at the Eighth American Association for Cancer Research (AACR) Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held November...
Previous Oral Contraceptive Use May Be Associated With Better Outcomes in Patients With Ovarian Cancer
Patients who develop ovarian cancer appear to have better outcomes if they have a history of oral contraceptive use, according to a study by Mayo Clinic researchers published by Jatoi et al in BMC Cancer. “Multiple studies from a variety of sources have indicated that oral contraceptives are ...
Protein CK5 a Marker for Cisplatin-Resistant Ovarian Cancer
A University of Colorado Cancer Center study recently published by Corr et al in the International Journal of Gynecological Cancer shows that protein cytokeratin 5 (CK5), known to be a marker of poor prognosis in breast cancer, also marks ovarian cancers likely to be resistant to the common...
ASTRO 2015: Image-Guided Intensity-Modulated Radiation Therapy Reduces Bowel Side Effects in Cervical Cancer Patients
For cervical cancer patients undergoing postsurgical radiation therapy, image-guided intensity-modulated radiation therapy (IMRT) resulted in a 14% reduction in moderate-to-severe bowel side effects when compared to conventional three-dimensional conformal radiation therapy (3D CRT), according to...
Bariatric Surgery May Resolve Precancerous Uterine Lining Changes in Obese Women
A study evaluating the effects of bariatric surgery on obese women most at risk for cancer has found that the weight-loss surgery slashed participants' weight by one-third and eliminated precancerous uterine growths in those who had them. Other effects included improving patients' physical quality...
Study Questions Cost-Effectiveness of Universal BRCA Screening
Women who are carriers of mutated BRCA genes are known to have a significantly higher risk for developing breast and ovarian cancers than those who do not have the mutations. A viewpoint published recently in JAMA Oncology by researchers at the University of California Los Angeles questioned...
Beta-Blockers May Prolong Survival in Women With Ovarian Cancer
In a first-of-its-kind study, researchers demonstrated a benefit in overall survival among patients with epithelial ovarian cancer receiving generic beta-blocker heart medications. Survival was shown to be greatest among those prescribed first-generation nonselective beta-blockers. According to...
Imaging Probe May Be More Accurate Than the Best External Detector for Early Cervical Cancer Diagnosis
An endovaginal magnetic resonance imaging technique is more accurate at detecting early-stage cervical cancer than the best available external detection technique, a new study reported. Researchers at The Institute of Cancer Research and The Royal Marsden Hospital found that using an...
Black Women Less Likely Than Women of Other Races and Ethnicities to Survive Endometrial Cancer
Non-Hispanic black women with endometrial cancer had worse outcomes than women of other racial/ethnic groups diagnosed with the same subtype of endometrial cancer and at the same stage of disease, according to a study published by Cote et al in Cancer Epidemiology, Biomarkers & Prevention....
Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment
Multigene testing of women who tested negative for BRCA1 and BRCA2 found some of them harbored other harmful genetic mutations—most commonly, moderate-risk breast and ovarian cancer genes, as well as Lynch syndrome genes (which increase the risk of ovarian cancer)—according to an...
Long-Term Survival in Ovarian Cancer May Be Better Than Expected in Some Patients
Combing data collected on thousands of California patients with ovarian cancer, University of California Davis researchers have determined that almost one-third of patients survived at least 10 years after diagnosis. The findings upend the notion that women diagnosed with cancer of the ovaries...
Birinapant in Combination With Carboplatin May Be Effective Against Serous Ovarian Cancer
High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but it frequently recurs after the first line of treatment. A team of University of California, Los Angeles, researchers has discovered that a subset of tumor cells that don’t produce the protein CA125, ...
Protein Imbalance in Akt Pathway May Trigger Cancer
Cancer can be caused solely by protein imbalance within cells, a study of ovarian cancer has found. Until now, genetic aberrations have been seen as the main cause of almost all cancer. The research, published by Timsah et al in Oncogene, demonstrates that protein imbalance is a powerful prognostic ...
Modified Mullerian-Inhibiting Substance Suppresses Growth of Some Recurrent Ovarian Tumors in Mouse Model
Use of gene therapy to deliver a protein that suppresses the development of female reproductive organs may improve the survival of patients with ovarian cancer that has recurred after chemotherapy. In a study published by Pepin et al in PNAS Early Edition, a Massachusetts General Hospital (MGH)...
New Research Uncovers Key Molecule in Ovarian Cancer
Scientists at Lawson Health Research Institute have uncovered an important new target for ovarian cancer therapy. Contrary to current research, this new study found that LKB1, a molecule that regulates the metabolism of many adult cells, is important in the cancer's promotion and survival. These...
Noninvasive Prenatal Testing May Also Detect Some Maternal Cancers
A study published by Bianchi et al in the Journal of the American Medical Association (JAMA) showed that genetic test results revealed by noninvasive prenatal testing for fetal chromosomal abnormalities may detect underlying conditions in the mother, including cancer. The study reports on a case...
Study Links Leisure Time Sitting to Higher Risk of Specific Cancers and Total Cancer Risk in Women
Spending more leisure time sitting was associated with a higher risk of total cancer risk in women, specifically heightened multiple myeloma, breast, and ovarian cancer risk, according to a new study by the American Cancer Society. The higher risk was present even after taking into account body...
Extended-Field Intensity-Modulated Radiation Therapy for Cervical and Endometrial Cancers Does Not Increase Risk of Duodenal Toxicity
Women with cervical or endometrial cancer who require treatment to the para-aortic lymph nodes can safely receive extended-field intensity-modulated radiation therapy without increased risk of duodenal toxicity, according to a study by Xu et al in Practical Radiation Oncology. Extended-Field...
ASCO Endorses ASTRO Guideline on Radiation Therapy After Surgery for Endometrial Cancer
The American Society of Clinical Oncology (ASCO) issued an endorsement of the American Society for Radiation Oncology (ASTRO) clinical practice guideline on postoperative radiation therapy for women with endometrial (uterine) cancer. The endorsement was published by Meyer et al in the Journal of...
Immune Signaling Protein May Have Opposing Roles in Breast Cancer Development
Researchers at The University of Texas MD Anderson Cancer Center have discovered that inhibiting the immune receptor protein TLR4 may not be a wise treatment strategy in all cancers, as research now shows TLR4 can either promote or inhibit breast cancer cell growth depending on mutations in...
Single Dose of HPV-16/18 Vaccine May Prevent Cervical Cancer
A single dose of the recombinant human papillomavirus (HPV) bivalent (types 16 and 18) vaccine (Cervarix) appears to be as effective in preventing certain HPV infections as three doses, the currently recommended course of vaccination, concluded a study published by Kreimer et al in The Lancet...
ASCO 2015: IMGN853 Demonstrates Single-Agent Activity for Patients With Platinum-Resistant Ovarian Cancer
In a phase I trial, the investigational agent mirvetuximab soravtansine (IMGN853) was found to be active in patients with platinum-resistant ovarian cancer. ImmunoGen, Inc, announced the first clinical findings of this folate-receptor alpha (FRα)-targeting antibody-drug conjugate at the...
Study Shows Nearly 15 Million Women Live Prohibitively Far From Access to Gynecologic Cancer Care
More than one-third of counties in the United States are located more than 50 miles from the nearest gynecologic oncologist, making access to specialty care for ovarian and other gynecologic cancers difficult for nearly 15 million women. Although most of these “low-access” counties are...
ASCO 2015: Mismatch Repair Deficiency Predicts Response to Pembrolizumab Among Patients With Colorectal and Other Cancers
A phase II study identified the first genomic marker—mismatch repair deficiency—to predict clinical benefit of immune checkpoint blockade with the anti–PD-1 antibody pembrolizumab (Keytruda). Among 50 patients with colorectal cancer, 62% of the 25 patients with mismatch...
Women With Inherited KRAS-Variant Mutation May Be at Increased Breast Cancer Risk Due to Acute Estrogen Withdrawal
Researchers at UCLA Jonsson Comprehensive Cancer Center have discovered that for women with a relatively common inherited mutation, known as the KRAS-variant, abrupt lowering of estrogen may increase their breast cancer risk and impact breast cancer biology. Scientists also found that women with...
Nine-Valent HPV Vaccine Protects Against 80% of Cervical Cancers
The new nine-valent human papillomavirus (HPV) vaccine (Gardasil 9) can potentially prevent 80% of cervical cancers in the United States, if given to all 11- or 12-year-old children before they are exposed to the virus. Additionally, the new vaccine, which includes seven cancer-causing...
Frequent Aspirin Use Reduces Risk of Cervical Cancer by Nearly Half
Long-term and frequent use of aspirin is associated with significantly decreased risk of cervical cancer, according to a study led by researchers at Roswell Park Cancer Institute and published by Friel et al in the Journal of Lower Genital Tract Disease. Study Findings Aspirin use was associated...
Fallopian Tube Removal May Protect Premenopausal Women at High Risk for Ovarian Cancer From Some Surgical Side Effects
A new surgical approach that removes the fallopian tubes—while sparing the ovaries—may provide premenopausal women at high risk for ovarian cancer, particularly those with BRCA1/2 mutations, with a surgical option that minimizes cancer risk while also reducing some of the negative...
AACR 2015: New PARP Inhibitor Combination Shows Early Promise for a Wide Range of Cancer Patients
A combination of two molecularly targeted drugs, olaparib (Lynparza) and the investigational agent AZD5363, was safe and yielded responses in patients with a variety of cancer types, including breast, ovarian, and prostate cancers, regardless of BRCA1/2-mutation status, according to data from the...
AACR 2015: Olaparib and Investigational PI3K Inhibitor BKM120 Combination Active Against Ovarian and Breast Cancer Subtypes
Combination treatment with the poly ADP-ribose polymerase (PARP) inhibitor olaparib (Lynparza) and the investigational phosphatidylinositol-3-kinase (PI3K) inhibitor BKM120 was safe and yielded evidence of clinical benefit for women with triple-negative breast cancer and for those with high-grade...
AACR 2015: HPV Vaccine Provides Protection at Multiple Sites, Even Among Some Previously Exposed Patients
Vaccination of women aged 18 to 25 with the human papillomavirus (HPV) vaccine resulted in strong protection against future infection at three anatomic sites among women without prior HPV exposure and may still offer some protection in those with evidence of prior exposure. These findings were...
AACR 2015: Investigational CART-meso Immunotherapy Feasible for Patients With Advanced Cancers
Patients with advanced cancers who received mesothelin-directed chimeric antigen receptor–modified T cells (CART-meso), a type of investigational adoptive immunotherapy, tolerated the treatment well, and there was evidence that the infused immune cells persisted in the patients’ blood...
Increasing Number of Boys Vaccinated Against HPV Could Protect More People at the Same Price
Public health programs that devote a portion of their funding to encourage more boys to be vaccinated against human papillomavirus (HPV)—rather than merely attempting to raise coverage among girls—may ultimately protect more people for the same price, a study from Duke University...
Risk of Breast and Ovarian Cancers May Differ by BRCA1/2 Mutation Type
Women who have inherited mutations in BRCA1 or BRCA2 (BRCA1/2) have an increased risk of breast and ovarian cancers. However, little has been known about how cancer risks differ by BRCA1/2 mutation type. In a study involving more than 31,000 women who are carriers of disease-associated mutations...
