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solid tumors

Factors in Clonal Evolution of Chemotherapy-Resistant Urothelial Carcinoma Identified

Faltas et al identified factors in the clonal evolution of chemotherapy-resistant urothelial carcinoma, according to a study reported in Nature Genetics. Findings included wide intrapatient mutational heterogeneity and enrichment for clonal mutations involving L1 cell–adhesion molecule...

solid tumors

Bishoy M. Faltas, MD, on Advanced Urothelial Carcinoma: Generating a Neoantigen Map

Bishoy M. Faltas, MD, of Weill Cornell Medical College, discusses his team’s work using whole exome sequencing, which may have important implications for selecting patients for immunotherapeutic approaches (Abstract 354).

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