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gynecologic cancer
colorectal cancer
head and neck cancer
issues in oncology
issues in oncology

100% of NCI-Designated Cancer Centers Endorse the Promotion of the HPV Vaccination for Cancer Prevention

All National Cancer Institute (NCI)-designated cancer centers have united to support human papillomavirus (HPV) vaccination. A team of HPV experts drafted a consensus statement that advises widespread use of HPV vaccines to prevent cancer. HPV causes cancer of the cervix, anus, and throat. The HPV ...

head and neck cancer

Couple Pledges $10 Million Gift to MD Anderson’s Head and Neck Cancer Center

The University of Texas MD Anderson Cancer Center in Houston, Texas, recently announced that Charles and Daneen Stiefel, of Raleigh, North Carolina, have pledged $10 million to the Head and Neck Cancer Center at MD Anderson. In honor of their generosity, the institution will name the Charles and...

head and neck cancer

The Center of Who We Are

The following essay by Eric M. Genden, MD, is adapted from The Big Casino: America’s Best Cancer Doctors Share Their Most Powerful Stories, which was coedited by Stan Winokur, MD, and Vincent Coppola and published in May 2014. The book is available on Amazon.com and thebigcasino.org.   There’s...

head and neck cancer

ESMO Asia 2015: Immunotherapy and Targeted Therapy Provide New Options for Difficult-to-Treat Head and Neck Cancer

Novel strategies are being explored for difficult-to-treat and advanced head and neck cancer—the most heterogeneous group of malignancies that are generally associated with poor survival—and encouraging results have been presented in two trials at the first European Society for Medical...

head and neck cancer
issues in oncology

Patients With Thyroid Cancer Report Poor Quality of Life Despite ‘Good’ Diagnosis

Thyroid cancer survivors report poor quality of life after diagnosis and treatment compared with other patients who are diagnosed with more lethal cancers, according to new research from the University of Chicago Medicine. The findings, published by Aschebrook-Kilfoy et al in the journal Thyroid,...

head and neck cancer
survivorship

Depressed Head and Neck Cancer Patients 3.5 Times Less Likely to Survive, Have Higher Recurrence Risk

Depression is a significant predictor of 5-year survival and recurrence in head and neck cancer patients, according to a new study from The University of Texas MD Anderson Cancer Center. These findings, published by Shinn et al in Psychosomatic Medicine, represent one of the largest reported...

kidney cancer
lung cancer
skin cancer
lymphoma
kidney cancer
head and neck cancer

Kidney Failure and Its Treatment May Impact Cancer Risk

For patients with kidney failure, poor kidney function and immunosuppressant medications may increase their risk of developing different types of cancer. The findings, which are published by Yanik et al in the Journal of the American Society of Nephrology, suggest the need for persistent cancer...

head and neck cancer
issues in oncology

Researchers Discover SEC23B, Gene Associated With Cowden Syndrome, Contributes to Thyroid Cancer Risk

Cleveland Clinic researchers have discovered a gene associated with Cowden syndrome, an inherited condition that carries high risks of thyroid, breast, and other cancers, and a subset of noninherited thyroid cancers. These findings were published by Yehia et al in the American Journal of Human...

head and neck cancer
supportive care

ASTRO 2015: Frequent Post-Treatment Follow-up by Advance Practice Nurses Improves Care for Patients With High-Risk Head and Neck Cancer

For high-risk patients who receive chemoradiotherapy for head and neck cancer, frequent follow-up appointments conducted by advance practice nurses (APNs) in a clinical outpatient setting allowed for more intensive symptom management, resulting in fewer post-treatment emergency room visits and...

head and neck cancer
issues in oncology

ASTRO 2015: Reduced-Intensity Chemoradiotherapy May Be as Effective as Current Standard for Patients With HPV-Related Oropharynx Cancer

For some patients with human papillomavirus (HPV)-related cancer of the tonsils and tongue, reduced-intensity radiation therapy and chemotherapy may be as effective as standard-dose radiation and chemotherapy, and result in fewer acute side effects, according to research presented by Chera et al...

head and neck cancer
issues in oncology

Disparities in Outcomes for Children With Retinoblastoma May Suggest Unequal Access to Primary Care

Disparities in outcomes for children with retinoblastoma suggest unequal access to primary care, researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center reported in a study published by Truong et al in JAMA Pediatrics. Although virtually all the children in the study...

head and neck cancer

ECC 2015: Pembrolizumab in Patients With Advanced Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Trial

Pembrolizumab (Keytruda), an anti–PD-1 therapy, may be effective as monotherapy in patients with advanced unresectable nasopharyngeal carcinoma whose tumors express programmed cell death-ligand 1 (PD-L1). Data from a phase Ib study, KEYNOTE-028, showed an overall response rate of 22.2% in 27...

head and neck cancer
survivorship

ECC 2015: Association Between Primary Surgery and Survival Benefit in Patients With Advanced Throat Cancers

Patients with cancers of the mid and lower throat may have higher survival rates if their initial treatment includes surgery, according to new research (Abstract 2804) presented at the 2015 European Cancer Congress in Vienna, Austria. Researchers explained that a nationwide study in Taiwan found...

issues in oncology
head and neck cancer

Researchers Discover Novel Marker for Retinoblastoma

A new marker already linked to other types of cancer was found to play a role in the most common childhood primary tumor inside the eye, researchers at the University of Michigan Health System have found. Their findings were published by Khan et al in Laboratory Investigation. Retinoblastoma is a...

head and neck cancer

Persistent HPV16 DNA in Post-Treatment Oral Rinse Associated With Poor Prognosis in HPV-Related Oropharyngeal Carcinoma

In a prospective cohort study reported in JAMA Oncology, Rettig et al found that persistent human papillomavirus (HPV) type 16 DNA in post-treatment oral rinses was associated with a poorer prognosis in patients with HPV-related oropharyngeal cancer. The study included 124 patients treated with...

head and neck cancer
issues in oncology

Susceptibility Gene Identified for Familial Nonmedullary Thyroid Cancer

As reported in The New England Journal of Medicine, Gara et al identified a germline HABP2 mutation as a susceptibility gene for familial nonmedullary thyroid cancer. Identification of HABP2 Variant In a kindred study, whole-exome sequencing was performed using peripheral blood DNA from affected...

issues in oncology
head and neck cancer
issues in oncology

Researchers Decode Molecular Action of Combination Therapy for Anaplastic Thyroid Cancer

In their bid to find the best combination of therapies to treat anaplastic thyroid cancer, researchers at Mayo Clinic's Florida campus demonstrated that all histone deacetylase (HDAC) inhibitors are not created equal. In testing multiple HDAC inhibitors in combination with the chemotherapy drug...

head and neck cancer
issues in oncology

30-Year Study Shows Moderate Hormone Suppression May Be Sufficient in Thyroid Cancer

A study of long-term thyroid cancer outcomes shows, among other findings, that moderate suppression of thyroid-stimulating hormone, which drives the disease, may be as beneficial as more extreme hormone suppression. Extreme thyroid-stimulating hormone suppression is associated with increased side...

head and neck cancer

Two-Thirds of Patients With Locally Advanced Laryngeal Cancer Not Receiving Recommended Treatment

Despite findings of previous studies and published guidelines, nearly two-thirds of patients with T4a laryngeal cancer are not receiving a total laryngectomy—the recommended form of treatment—and, as a result, have significantly worse survival rates vs those treated with a total...

issues in oncology
head and neck cancer
issues in oncology
issues in oncology

DNA Shed From Head and Neck Tumors Detected in Blood and Saliva

On the hunt for better cancer screening tests, Johns Hopkins scientists led a proof-of-principle study that successfully identified tumor DNA shed in the blood and saliva of 93 patients with head and neck cancer. A report on the findings was published by Wang et al in Science Translational...

palliative care
colorectal cancer
head and neck cancer

Development of New Blood Vessels Not Essential to Growth of Lymph Node Metastases

While the use of antiangiogenesis drugs that block the growth of new blood vessels can improve the treatment of some cancers, clinical trials of their ability to prevent the development of new metastases have failed. Now a study from the Massachusetts General Hospital (MGH) Cancer Center may have...

issues in oncology
breast cancer
head and neck cancer
gynecologic cancer
issues in oncology
bladder cancer
issues in oncology

Immune Signaling Protein May Have Opposing Roles in Breast Cancer Development

Researchers at The University of Texas MD Anderson Cancer Center have discovered that inhibiting the immune receptor protein TLR4 may not be a wise treatment strategy in all cancers, as research now shows TLR4 can either promote or inhibit breast cancer cell growth depending on mutations in...

issues in oncology
head and neck cancer

Lymph Nodes Signal More Aggressive Thyroid Cancer, Even in Young Patients

Patients older than age 45 with thyroid cancer that has spread to neck lymph nodes have long been considered at higher risk of dying, but the same has not been true for younger patients. Now researchers at the Duke Cancer Institute and the Duke Clinical Research Institute have found that...

issues in oncology
head and neck cancer
issues in oncology

HPV Serum Antibodies May Predict Survival and Disease Progression in Patients With HPV-Positive Oropharyngeal Cancer

A study by Dahlstrom et al investigating the usefulness of serum antibodies to human papillomavirus (HPV)-16 DNA antigens as predictors of survival for patients with oropharyngeal carcinoma has found that E1, NE2, and E6 antibody positivity were all strongly associated with improved overall and...

head and neck cancer

ASCO 2015: Elective Neck Dissection Improves Early Oral Cancer Survival

A randomized phase III study resolves long-standing questions about the optimal timing of neck lymph node surgery for patients with early-stage oral cancer by showing that elective neck dissection both improves survival and lowers recurrence rates compared to therapeutic neck dissection performed...

head and neck cancer

ASCO 2015: Pembrolizumab Produces Clinically Meaningful Response in Patients With Recurrent or Metastatic Head and Neck Cancer

Immunotherapy with pembrolizumab (Keytruda) produced a clinically meaningful overall response rate in a study among 132 patients with recurrent or metastatic squamous cell carcinoma of the head and neck. The overall objective response rate was 24.8%, and 57% of patients experienced some tumor...

head and neck cancer

Updated Meta-Analysis Confirms Survival Benefit of Adding Chemotherapy to Radiotherapy in Nasopharyngeal Cancer

In an updated patient-level meta-analysis reported in The Lancet Oncology, Blanchard et al of the Meta-Analysis of Chemotherapy in Nasopharyngeal Carcinoma (MAC-NPC) collaborative group found that the addition of chemotherapy to radiotherapy improved overall survival in patients with nasopharyngeal ...

gynecologic cancer
solid tumors
gynecologic cancer
head and neck cancer
issues in oncology

Nine-Valent HPV Vaccine Protects Against 80% of Cervical Cancers

The new nine-valent human papillomavirus (HPV) vaccine (Gardasil 9) can potentially prevent 80% of cervical cancers in the United States, if given to all 11- or 12-year-old children before they are exposed to the virus. Additionally, the new vaccine, which includes seven cancer-causing...

head and neck cancer

Afatinib Improves Progression-Free Survival vs Methotrexate in Platinum-Treated Recurrent or Metastatic Head and Neck Cancer

In the phase III LUX-Head & Neck 1 trial reported in The Lancet Oncology, Machiels et al found that afatinib (Gilotrif) improved progression-free survival vs methotrexate in patients with recurrent or metastatic squamous cell carcinoma of the head and neck progressing after first-line platinum...

gynecologic cancer
head and neck cancer
issues in oncology

AACR 2015: HPV Vaccine Provides Protection at Multiple Sites, Even Among Some Previously Exposed Patients

Vaccination of women aged 18 to 25 with the human papillomavirus (HPV) vaccine resulted in strong protection against future infection at three anatomic sites among women without prior HPV exposure and may still offer some protection in those with evidence of prior exposure. These findings were...

head and neck cancer
issues in oncology

Study Finds Large Disparities in Survival Among Adolescents and Young Adults With Differentiated Thyroid Cancer

A large, diverse study of 16,827 adolescents and young adults with differentiated thyroid cancer has found that African Americans and Hispanics were six times and three times more likely, respectively, to die of their cancer than Caucasians. Residing in low-socioeconomic neighborhoods, insurance...

gynecologic cancer
head and neck cancer
issues in oncology
cost of care

Increasing Number of Boys Vaccinated Against HPV Could Protect More People at the Same Price

Public health programs that devote a portion of their funding to encourage more boys to be vaccinated against human papillomavirus (HPV)—rather than merely attempting to raise coverage among girls—may ultimately protect more people for the same price, a study from Duke University...

head and neck cancer

Stereotactic Body Radiotherapy Plus Cetuximab Appears Safe, Effective in Previously Irradiated Recurrent Head and Neck Squamous Cell Carcinoma

In patients with previously irradiated recurrent squamous cell carcinoma of the head and neck, the combination of stereotactic body radiation therapy plus cetuximab (Erbitux) appears to be safe and effective, according to a study by Vargo et al in the International Journal of Radiation Oncology...

head and neck cancer

Erythropoietin Plus Radiation Therapy Does Not Improve Local-Regional Control in Anemic Patients With Head and Neck Cancer

Long-term analysis of Radiation Therapy Oncology Group (RTOG) 9903 demonstrates that the addition of erythropoietin did not improve local-regional control for anemic patients with head and neck squamous cell carcinoma who receive radiation therapy or chemoradiation, according to a study published...

head and neck cancer
issues in oncology

Effect of Smoking and Alcohol Consumption on Feeding Tube Duration in Head and Neck Cancer Patients

Current smoking and heavy alcohol consumption appear to be risk factors for prolonged use of a gastrostomy tube in patients with head and neck cancer undergoing radiotherapy or chemoradiotherapy. The findings were published in a report by O’Shea et al in JAMA Otolaryngology-Head & Neck...

head and neck cancer

Thyroid Cancer Rare in Patients With Asymptomatic Benign Nodules

A prospective, multicenter, observational study involving 992 consecutive patients with one to four asymptomatic, sonographically or cytologically benign thyroid nodules found that “the majority of nodules exhibited no significant size change during 5 years of follow-up or they actually...

breast cancer
head and neck cancer

New Analysis Reports Increased Risk of Thyroid Cancer After Breast Cancer Diagnosis

Breast cancer survivors are at increased risk of developing thyroid cancer, especially within 5 years of their breast cancer diagnosis, according to a new analysis of a large national database. The study results were presented at the Endocrine Society's 97th Annual Meeting. “Recognition of...

head and neck cancer

Improved TNM Prediction of Survival in HPV‑Related Oropharyngeal Carcinoma

In a study reported in the Journal of Clinical Oncology, Huang et al showed that recursive portioning analysis (RPA) could be used to provide TNM stage grouping with improved prediction of survival in patients with human papillomavirus (HPV)-related nonmetastatic oropharyngeal carcinoma. ...

head and neck cancer

FDA Approves Lenvatinib for Progressive Radioiodine-Refractory Differentiated Thyroid Cancer

The U.S. Food and Drug Administration (FDA) today granted approval to lenvatinib (Lenvima) to treat patients with progressive, differentiated thyroid cancer whose disease progressed despite receiving radioactive iodine therapy. Lenvatinib is a tyrosine kinase inhibitor that binds to multiple sites...

head and neck cancer

Lenvatinib Shows Promise for Patients With Radioiodine-Refractory Thyroid Cancer in Phase III Study

In a phase III study led by researchers at The University of Texas MD Anderson Cancer Center, the oral antiangiogenic therapy lenvatinib has shown dramatic improvement in progression-free survival in patients with advanced radioiodine-refractory thyroid cancer. Their findings are published by...

head and neck cancer

No Benefit of Panitumumab Plus Radiotherapy vs Cisplatin-Based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

In the phase II CONCERT-2 trial reported in The Lancet Oncology, Giralt et al found that treatment with the EGFR inhibitor panitumumab (Vectibix) plus concurrent radiotherapy was associated with poorer local-regional control vs cisplatin chemoradiation in previously untreated patients with...

head and neck cancer

No Benefit of Adding Panitumumab to Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

In the phase II CONCERT-1 trial reported in The Lancet Oncology, Mesía et al found that adding the EGFR inhibitor panitumumab (Vectibix) to standard cisplatin chemoradiation provided no benefit in previously untreated patients with unresected stage III to IVB head and neck squamous cell...

head and neck cancer

Dabrafenib May Stimulate Radioiodine Uptake in Patients With Iodine-Refractory Papillary Thyroid Cancer

In patients with iodine-refractory papillary thyroid cancer, the addition of dabrafenib (Tafinlar) therapy was shown to stimulate radioiodine uptake in thyroid cancer cells, according to a report by Rothenberg et al in Clinical Cancer Research. This approach has the potential advantage of requiring ...

head and neck cancer
issues in oncology

Study Uncovers Range of Molecular Alterations in Head and Neck Squamous Cell Carcinomas, New Potential Drug Targets

Investigators with The Cancer Genome Atlas (TCGA) Research Network have discovered genomic differences—with potentially important clinical implications—in human papillomavirus (HPV)-associated head and neck cancers. These findings were reported in Nature. The researchers also uncovered ...

head and neck cancer
issues in oncology

Head and Neck Cancers in Young Adults More Likely to Be a Result of Inherited Factors

Data from 25 case-control studies and separate analyses show that head and neck cancers in young adults are more likely to occur as a result of inherited factors rather than lifestyle factors, such as smoking or drinking alcohol, according to a new study by Toporcov et al published in the...

head and neck cancer

Oral Human Papillomavirus Infection More Likely to Persist in Older Men

Oral infection with human papillomavirus 16 (HPV16), which is the type of HPV most frequently linked to HPV-driven head and neck cancers, was more likely to persist 12 or more months in men older than 45 than in those younger than 45, according to a study reported by Pierce Campbell et al in...

head and neck cancer

Nonoperative Management Should Be Used With Caution in Patients With Small Papillary Thyroid Tumors

In a population-based study of patients with thyroid cancer, 12.3% of patients with small papillary thyroid tumors experienced thyroid cancer–related deaths despite undergoing thyroidectomy, according to a report by Nilubol and Kebebew in the journal Cancer. From the results of this study,...

head and neck cancer

Institutional Experience Significantly Affects Overall Survival in Locally Advanced Head and Neck Cancer

In a study reported in the Journal of Clinical Oncology, Wuthrick et al found that patients with stage III or IV head and neck cancer in the Radiation Therapy Oncology Group (RTOG) 0129 trial who were treated at historically high-accruing centers in RTOG clinical trials had significantly better...

head and neck cancer

RTOG 0129 Long-Term Results: No Differences in Survival or Toxicity With Accelerated vs Standard Fractionation Plus Cisplatin in Head and Neck Cancer

As reported in the Journal of Clinical Oncology by Nguyen-Tan et al, long-term follow-up in the phase III Radiation Therapy Oncology Group (RTOG) 0129 trial indicates no difference in overall survival or late toxicity with use of accelerated vs standard radiation therapy plus cisplatin in patients...

head and neck cancer

BRAF V600E Mutation Predicts Recurrence of Papillary Thyroid Cancer

In a large retrospective study reported in the Journal of Clinical Oncology, Xing et al found that presence of the BRAF V600E mutation was an independent predictor of recurrence of papillary thyroid cancer. The study involved 2,099 patients with papillary thyroid cancer consecutively selected over ...

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