This is a provocative study, showing unexpected differences in acute skin reactions with conventional fractionation vs hypofractionation. Some studies have failed to show differences in acute toxicities between these two types of radiation therapy,” said Kenneth B. Roberts, MD, Professor of Therapeutic Radiology at Yale University School of Medicine, New Haven, Connecticut.
“In the past, there has been some undue concern about hypofractionation causing more toxicity. The concept behind this is that higher doses per fraction would be theorectically associated with greater toxicity. In fact, this study showed less acute toxicity and less skin reaction with hypofractionated radiation therapy. And a striking aspect of this study is that all patients received a breast boost. This study lends support that we can use a radiation regimen that is completed more quickly and is more convenient for patients. We are giving an equivalent therapy in terms of disease control and the patient is getting radiation within 4 weeks instead of 6½ weeks,” Dr. Roberts stated. ■
Disclosure: Dr. Roberts reported no potential conflicts of interest.
Hypofractionated whole-breast irradiation was associated with much less acute toxicity during radiation therapy compared with conventionally fractionated whole-breast irradiation and also led to improved physical well-being and less physician-reported and patient-reported fatigue 6 months later,...