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Skin Cancer

FDA Approves Avelumab for Metastatic Merkel Cell Carcinoma

The U.S. Food and Drug Administration (FDA) today granted accelerated approval to avelumab (Bavencio) for the treatment of adults and pediatric patients 12 years and older with metastatic Merkel cell carcinoma, including those who have not received prior chemotherapy. Avelumab is a programmed cell death ligand 1 (PD-L1)–blocking human IgG1 lambda monoclonal antibody. This is the first FDA-approved treatment for metastatic Merkel cell carcinoma, a rare, aggressive form of skin cancer.

Prostate Cancer

No Benefit From Older Standard-of-Care Drug in Adjuvant Chemotherapy for High-Risk Prostate Cancer, but Newer Trials Feasible

An older trial designed to evaluate the benefits of adjuvant therapy following radical prostatectomy in patients with high-risk prostate cancer showed no difference in overall or disease-free survival between 2 years of androgen-deprivation therapy and 2 years of androgen-deprivation therapy plus chemotherapy with mitoxantrone and prednisone.

Lung Cancer

Immunotherapy Combinations Gain Traction in Lung Cancer

Combining immunotherapies with each other or with other agents such as chemotherapy and growth factor inhibitors holds promise for better tapping their benefit in patients with lung cancer, data from several studies suggest. Results show that strategic combinations can achieve higher response rates, more durable responses, and may make immunotherapy an option for a broader population of patients. Here we review some of the data from three trials presented at the International Association for the Study of Lung Cancer 17th World Conference on Lung Cancer.


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Solid Tumors

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Expert Point of View: Ann H. Partridge MD, MPH

Ann H. Partridge MD, MPH, Director of Adult Cancer Survivorship Program at the Dana-Farber Cancer Institute, praised the “tremendous work” of Dr. Paskett and her colleagues but referred to the findings as “disappointing to say the least.”1

“Developing interventions to prevent or treat lymphedema ...

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FDA Approves Avelumab for Metastatic Merkel Cell Carcinoma

The U.S. Food and Drug Administration (FDA) today granted accelerated approval to avelumab (Bavencio) for the treatment of adults and pediatric patients 12 years and older with metastatic Merkel cell carcinoma, including those who have not received prior chemotherapy. Avelumab is a programmed cell...

Prostate Cancer

Paul L. Nguyen, MD, on Predicting Metastasis and Mortality

Fox Chase Junior Investigators Win Awards for Pilot Projects

Fox Chase Cancer Center is pleased to announce the results of its American Cancer Society Institutional Research Grant Pilot Project Competition for Junior Investigators. The competition was open to eligible junior faculty at Fox Chase and Temple University Hospital.

The awardees are Yibin...

Solid Tumors
Colorectal Cancer

Reducing Debilitating Symptoms of Advanced Colorectal Cancer

In a phase III trial reported in The Lancet Oncology, Tamas Hickish, MD, of Poole Hospital NHS Foundation Trust, Dorset, England, and colleagues found that treatment with MABp1, an antibody that targets interleukin 1α and exhibits antitumor activity, was associated with improvement in the composite ...

SSO 2017: Preclinical Trial Shows Intratumoral Vaccination Induces Antitumor Response in Pancreatic Cancer

Building on their previous research focusing on intratumoral vaccination for the most common form of pancreatic cancer, investigators from Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School have shown that in a mouse model of early-stage resected pancreatic...

Prostate Cancer

Paul L. Nguyen, MD, on Predicting Metastasis and Mortality

Health-Care Policy
Pain Management

ASCO Addresses New Policies That Threaten Access to Opioids

Since the mid-2000s, medication and illicit drug abuse in the United Sates has steadily increased, creating what has now been termed an “opioid epidemic.” In response, Congress and the Bush and Obama Administrations have launched intervention and regulatory proposals to help turn the troubling...

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IASLC Endorses Tobacco Reform Report Outlining Progress Toward Ending Adult Cigarette Smoking

The International Association for the Study of Lung Cancer (IASLC) has endorsed a report released by the Core Team for Tobacco Control that outlines key action items that can be taken immediately to accelerate progress toward ending cigarette smoking in adults.

Issuing their Executive Summary ...


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