Advertisement

Expert Point of View: Andrea Necchi, MD


Advertisement
Get Permission

Andrea Necchi, MD

Andrea Necchi, MD

Formal discussant of the EV-201 trial, Andrea Necchi, MD, of the Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy, found the data pending phase III studies promising: “This study explored enfortumab vedotin in a newly defined population who failed to respond to prior chemotherapy and a checkpoint inhibitor. These patients were highly pretreated. We will also have to determine whether the efficacy is reproducible with other antibody-drug conjugates. Toxicity favors antibody-drug conjugates. After checkpoint inhibitor failure, antibody-drug conjugates are in the best position as the next in line for the standard of care, but we still need biomarkers,” Dr. Necchi stated. 

DISCLOSURE: Dr. Necchi has received honoraria from Roche, Merck, AstraZeneca, Janssen, and Foundation Medicine; has served as a consultant/advisor for Merck Sharp & Dohme, Roche, Bayer, AstraZeneca, Clovis Oncology, Janssen, Incyte, Seattle Genetics/Astellas, Bristol-Myers Squibb, and Rainier Therapeutics; has received institutional research funding from Merck Sharp & Dohme and AstraZeneca; has received travel expenses from Roche, Merck Sharp & Dohme, AstraZeneca, Janssen, and Rainier Therapeutics; and has an immediate family member who has other relationships with Bayer.


Related Articles

Enfortumab Vedotin After Checkpoint Inhibition in Metastatic Urothelial Cancer

A phase II study found that treatment with the antibody-drug conjugate enfortumab vedotin achieved responses in 44% of patients with locally advanced or metastatic urothelial cancer previously treated with platinum chemotherapy and a checkpoint inhibitor. This is a noteworthy study because it...

Advertisement

Advertisement



;
Advertisement