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Immunotherapy
Gastroesophageal Cancer

Bemarituzumab for FGFR2b-Overexpressing Gastroesophageal Adenocarcinoma

In a phase I trial reported in the Journal of Clinical OncologyDaniel V.T. Catenacci, MD, PhD, and colleagues found that the...

Issues in Oncology

ASCO Coronavirus Resources

As the coronavirus (COVID-19) continues to spread, organizations all over the world are focusing on the health and safety of their...

Breast Cancer

Quality of Life After Adjuvant Radiotherapy With vs Without Tumor Bed Boost for Patients With Non–Low-Risk DCIS

In a health-related quality-of-life study reported in The Lancet Oncology, King et al found that adjuvant radiotherapy with a...


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Immunotherapy
Hematologic Malignancies

Bispecific Antibodies: Successes and Challenges

Bispecific T-cell engager (BiTE) antibodies, such blinatumomab, may be the most appealing type of bispecific antibodies...

Issues in Oncology
Lung Cancer

Disparities in Receipt of Chemotherapy Among Patients With pN1 Lung Cancer

In patients with non–small cell lung cancer (NSCLC) where the cancer has spread to one or more lymph nodes close to the lung...

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Breast Cancer
Genomics/Genetics

Nicholas C. Turner, MD, PhD, on ctDNA Testing to Direct Targeted Therapies in Advanced Breast Cancer

Issues in Oncology

A Message From the FDA OCE for Patients With Cancer and Health-Care Providers on COVID-19

On March 23, the U.S. Food and Drug Administration (FDA) Oncology Center of Excellence (OCE) issued the following statement: The FDA OCE recognizes that patients with cancer constitute a vulnerable population at risk of contracting the coronavirus disease (COVID-19). While everyone’s daily lives...

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Impact of Genes on Total Number and Type of Nevi

A study by Duffy et al in the Journal of Investigative Dermatology reported on specific gene variations affecting the number and types of moles on the body and their role in causing skin cancer.  “The goal was to investigate the genetic underpinnings of different mole classes, or...

Immunotherapy

Dario Vignali, PhD, on Immune Resistance Mechanisms in Cancer

Issues in Oncology

COVID-19 and Pediatric Patients With Cancer

In a correspondence published in The Lancet Oncology, Rishi S. Kotecha, MB, ChB, of the Government of Western Australia Department of Health, identified challenges in protecting children with cancer from COVID-19 infection and stressed that some measures proposed to protect adults with cancer may...

Gynecologic Cancers

Risk of Cervical Cancer With Different Types of Intrauterine Devices

Patients who used copper intrauterine devices (IUDs) were found to have a lower risk of high-grade cervical neoplasms vs users of the levonorgestrel-releasing intrauterine system, according to a study published by Spotnitz et al in the journal Obstetrics & Gynecology. The study notes that more...

Gemcitabine/Eribulin in Cisplatin-Ineligible Metastatic Urothelial Carcinoma

In the final analysis from a phase II California Cancer Consortium trial (NCI-9653) reported in the Journal of Clinical Oncology, Sadeghi et al found the combination of gemcitabine and eribulin showed activity in cisplatin-ineligible patients with metastatic urothelial carcinoma. Study Details...

Immunotherapy
Bladder Cancer

Jonathan E. Rosenberg, MD, on Locally Advanced or Metastatic Urothelial Carcinoma: Enfortumab Vedotin Plus Pembrolizumab

Issues in Oncology
Survivorship

Cancer Incidence and Survivorship in Transgender Patients

The first-ever population-based study of cancer prevalence in transgender people was recently published by Boehmer et al in the journal Cancer. The authors of the report estimate that 62,530 of the nearly 17 million cancer survivors in the United States are transgender. Methods The researchers used ...

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Deintensified Chemoradiotherapy for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

In a phase II trial reported in the Journal of Clinical Oncology, Chera et al found that deintensified chemoradiotherapy produced favorable outcomes in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma. Study Details In the multicenter trial, 114 patients were recruited...