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Lung Cancer

Entrectinib in Advanced ROS1 Fusion–Positive NSCLC

An integrated analysis of three phase I/II trials has shown high activity of the TRK and ROS1 inhibitor entrectinib in ROS1 fusion-positive non–small cell lung cancer (NSCLC)...

Breast Cancer

Mixed Results With Weekly Nab-paclitaxel, Denosumab in Primary Breast Cancer

A weekly schedule of nab-paclitaxel as part of neoadjuvant chemotherapy significantly improved pathologic complete response compared with nab-paclitaxel in patients with primary breast cancer...

Myelodysplastic Syndromes
Gynecologic Cancers
Bladder Cancer
Gastrointestinal Cancer

Luspatercept in Transfusion-Dependent Lower-Risk Myelodysplastic Syndromes

We’ll start off this week on The ASCO Post Podcast by discussing results from the MEDALIST trial of luspatercept in transfusion-dependent lower-risk myelodysplastic syndromes...

 

 

 


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Lung Cancer

Impact of the NCI Cell-Line Database: A Testament to Patient Altruism

In an homage to gracious patients and dedicated researchers, James L. Mulshine, MD, and colleagues have described the impact of the NCI cell-line database over the past 25 years...

Immunotherapy
Skin Cancer
Sarcoma
Kidney Cancer

Three Studies Examine Relationship Between B-Cell Enrichment and Response to Immunotherapy

The likelihood of a patient responding to immune checkpoint blockade may depend on B cells in the tumor, according to three studies all recently published in Nature...

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More Top Stories

Leukemia

Jerald P. Radich, MD, on CML: Predicting Deep Molecular Response to Treatment

Hematologic Malignancies

Transplantation Specialist Karen Ballen, MD, Treasures Long-Term Connections With Her Patients

Karen Ballen, MD, an international expert in stem cell transplantation, particularly for patients who have a difficult time finding a donor, was born and reared in the Bronx in a family that encouraged academic and professional pursuits. “My grandfather was an old-fashioned pediatrician who made...

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Impact of Genes on Total Number and Type of Nevi

A study by Duffy et al in the Journal of Investigative Dermatology reported on specific gene variations affecting the number and types of moles on the body and their role in causing skin cancer.  “The goal was to investigate the genetic underpinnings of different mole classes, or...

Breast Cancer
Immunotherapy

Hope S. Rugo, MD, on HER2-Positive Metastatic Breast Cancer: SOPHIA Trial of Chemotherapy Plus Margetuximab or Trastuzumab

Myelodysplastic Syndromes

Luspatercept in Transfusion-Dependent Lower-Risk Myelodysplastic Syndromes

In the phase III MEDALIST trial reported in The New England Journal of Medicine, Fenaux et al found that luspatercept significantly reduced the severity of anemia vs placebo in red blood cell transfusion–dependent patients with very low- to intermediate-risk myelodysplastic syndromes with ring...

Multiple Myeloma

Selected Abstracts on New Therapies for Newly Diagnosed Multiple Myeloma

To complement The ASCO Post’s comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel therapeutic regimens including the monoclonal antibody daratumumab in combination ...

Gemcitabine/Eribulin in Cisplatin-Ineligible Metastatic Urothelial Carcinoma

In the final analysis from a phase II California Cancer Consortium trial (NCI-9653) reported in the Journal of Clinical Oncology, Sadeghi et al found the combination of gemcitabine and eribulin showed activity in cisplatin-ineligible patients with metastatic urothelial carcinoma. Study Details...

Lymphoma

Loretta J. Nastoupil, MD, on Follicular Lymphoma: Trial Results With Obinutuzumab/Lenalidomide

Lung Cancer

Impact of the NCI Cell-Line Database: A Testament to Patient Altruism

In an homage to the gracious patients who provided biospecimens and to the dedicated researchers who have tended and studied the derived cell lines, James L. Mulshine, MD, of the Center for Healthy Aging, Department of Internal Medicine, Rush University, and colleagues have described the impact of...

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Deintensified Chemoradiotherapy for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

In a phase II trial reported in the Journal of Clinical Oncology, Chera et al found that deintensified chemoradiotherapy produced favorable outcomes in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma. Study Details In the multicenter trial, 114 patients were recruited...