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Issues in Oncology

AACR Environmental Carcinogenesis: Lowering Exposure to Nitrates in Drinking Water May Reduce U.S. Cancer Cases

Nitrate levels in water resources have increased in many areas of the world, largely due to the use of inorganic fertilizer and animal manure in agricultural areas. Research has shown that the risk of specific cancers and birth defects may be increased when nitrate is ingested under conditions that increase levels of N-nitroso compounds.

Breast Cancer

Personalized Assay May Aid in Determining Risk of Recurrence of Triple-Negative Breast Cancer

Sixty percent of patients with triple-negative breast cancer will survive more than 5 years without disease after standard treatment, but 4 out of 10 women will have a rapid recurrence of the disease. There are currently no clinical tests to assess an individual patient’s prognosis, so all patients receive aggressive chemotherapy. Katherine Varley, PhD, a researcher at the Huntsman Cancer Institute and Assistant Professor of Oncological Sciences at the University of Utah, and colleagues recently published findings in Cancer Research that may allow for more personalized assessment of risk of recurrence.

Colorectal Cancer

2019 ASCO: Resection of Liver Metastases

In this episode of The ASCO Post Podcast, we discuss more news from the ASCO Annual Meeting, including findings from a study with relevance to surgical oncology...


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Immunotherapy
Lung Cancer

KEYNOTE-001 Shows Long-Term Survival Benefit With Pembrolizumab in Advanced NSCLC

Before the introduction of immunotherapy with checkpoint inhibitors, the 5-year life expectancy for patients with advanced non–small cell lung cancer (NSCLC) was 5.5%. This dismal outlook has changed. Treatment with the immune checkpoint inhibitor pembrolizumab dramatically improved overall survival in this group of patients, according to 5-year follow-up data from the phase Ib KEYNOTE-001 clinical trial. The greatest benefit of pembrolizumab was observed in patients with high programmed cell death ligand 1 (PD-L1) expression (≥ 50%).

Issues in Oncology

10 Patient-Centered Principles for More Conservative Cancer Diagnosis

Although diagnostic errors date back to antiquity, in recent years, they have begun to receive attention as an important patient safety issue. This culminated in the National Academy of Medicine’s 2015 landmark report, which concluded that most people in the United States would experience at least one diagnostic error in their lifetime. Diagnostic errors are the leading cause of medical malpractice claims, and cancer is the most frequently missed or delayed diagnosis.

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More Top Stories

Prostate Cancer

Miriam Knoll, MD, and Zachery Reichert, MD, PhD, on Prostate Cancer: Focal Radiation for Oligometastatic Castration-Resistant Disease

Hepatobiliary Cancer
Gynecologic Cancers

Aspirin Use and Cancer Prevention: Long-Term Data Needed on Benefits and Risks

In addition to its well-known cardioprotective benefits, aspirin has a substantial body of observational, preclinical, and clinical evidence supporting its efficacy in preventing cancer, most strongly for colorectal cancer.1 The strength of this evidence led the U.S. Preventive Services Task...

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Study Finds Primary Care Providers Are Engaged in Cancer Survivorship Care but Report Barriers to Optimal Care Delivery

A new study published by McDonough et al in the Journal of Oncology Practice found that while primary care physicians are often involved in cancer survivorship care, many do not feel adequately prepared for key components of it. The study shared the results of a survey of 117...

Bladder Cancer

Brian C. Baumann, MD, on Locally Advanced Bladder Cancer: Adjuvant Radiotherapy After Radical Cystectomy

Ahead of the Curve, Breast Cancer Specialist Advocates Prevention Through Exercise and Lifestyle

Breast cancer specialist Julie Gralow, MD, FASCO, Director, Breast Medical Oncology, Seattle Cancer Care Alliance, has a straightforward philosophy about her career: “Cancer is about living, not dying. I enjoy helping my patients with breast cancer take control of their health through...

Offerings From the ASCO Research Community Forum

Members of the research community can access resources developed by the ASCO Research Community Forum year-round to address challenges they may be facing in conducting and managing clinical trials, including the ASCO Toolkit of Resources on the Business of Clinical Trials; the ASCO Insurance...

Link Between Poor Oral Health and Increased Liver Cancer Risk

Poor oral health is associated with an increased risk of hepatocellular carcinoma, according to new research published by Jordão et al in the United European Gastroenterology Journal. Methods “Poor oral health has been associated with the risk of several chronic diseases, such as...

Multiple Myeloma

Francesca Gay, MD, on Multiple Myeloma: Carfilzomib/Lenalidomide/Dexamethasone With or Without Transplantation

Ronald Walters, MD, and Ruth O’Regan, MD, Elected to NCCN Board of Directors

The National Comprehensive Cancer Network® (NCCN®) recently announced the election of Ronald Walters, MD, to the role of Chair of the Board of Directors and Ruth O’Regan, MD, was named Vice Chair. Dr. Walters is Associate Head for the Institute for Cancer Care Innovation and a breast cancer...

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AACR Environmental Carcinogenesis: Silicone-Based Wristbands for Detection of Occupational Environmental Exposures for Firefighters

First responders such as paramedics and firefighters may be exposed to hazardous occupational environmental exposures, but linking these exposures to conditions such as cancers is difficult due to the latency period of disease, magnitude of potential exposure, and potential interactions of...