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Leukemia

Phase III Data Support Use of Gilteritinib in Relapsed or Refractory FLT3-Mutated AML

Treatment with gilteritinib, an oral type 1, FLT inhibitor, significantly improved overall survival compared with chemotherapy in patients with FLT3-positive...

Immunotherapy

The Microbiome: The Next Target in Cancer Therapy

With the recent breakthroughs in immunotherapy, treatments that modulate the immune system are now being used across numerous cancer types...

Lung Cancer
Issues in Oncology

Shared Decision-Making in Lung Cancer Screening: Whence? Whither?

We read with interest a recent article published on ASCOPost.com, which summarized a paper on the role of shared decision-making...


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Breast Cancer

Biomarkers Can Now Help Guide Treatment Selections in Breast Cancer

A growing list of biomarkers is beginning to drive targeted therapy in breast cancer, and clinicians can take advantage of these assays to make treatment selections...

Multiple Myeloma

PRIMeR Study Explores Meaning of Minimal Residual Disease in Myeloma

In a study that earned a Best Abstract Award at the 2019 Transplantation & Cellular Therapy (TCT) Meetings in Houston, minimal residual disease...

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Pancreatic Cancer

Heinz-Josef Lenz, MD, on Pancreatic Cancer Tumor Profiling and Treatment Response: Results From the COMPASS Trial

Giulio Draetta, MD, PhD, Named Chief Scientific Officer at MD Anderson

The University of Texas MD Anderson Cancer Center has named Giulio Draetta, MD, PhD, as Chief Scientific Officer, a new position that champions innovation, develops strong partnerships, and provides focused leadership on the science and clinical translation of research programs. Dr. Draetta joined ...

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Low-Dose Tamoxifen vs Placebo in Preventing Local and Contralateral Recurrence in Breast Intraepithelial Neoplasia

In an Italian phase III study reported in the Journal of Clinical Oncology, DeCensi et al found that tamoxifen at 5 mg/d vs placebo for 3 years reduced the risk of recurrence of breast intraepithelial neoplasia and was associated with limited toxicity. As noted by the investigators,...

Lung Cancer

Susan Y. Wu, MD, on Non–Small Cell Lung Cancer: Using an Online Tool in Treatment

Photos From the 2019 ASCO-SITC Clinical Immuno-Oncology Symposium

Arie S. Belldegrun, MD, FACS (right), receives the Keynote Award before delivering his lecture on “Progress in Cell Therapy: A Three-Decade Personal Journey.” Dr. Belldegrun is Surgical Director of the Genitourinary Oncology Department at the University of California, Los Angeles. The award was...

Well-Deserved Attention on Lung Cancer Screening

SCREENING FOR LUNG CANCER among high-risk groups deserves the attention that Steven E. Vogl, MD, brought to it in his column At Microphone 1 in the February 10 issue of The ASCO Post. Subspecialist oncologists are not always attuned to the needs of their patients outside of their own specialty.1...

SUNSHINE Trial: High-Dose Vitamin D May Benefit Patients With Metastatic Colorectal Cancer

Results of a small clinical trial suggest that supplementing chemotherapy with high doses of vitamin D may benefit patients with metastatic colorectal cancer by delaying progression of the disease. These findings were published by Ng et al in JAMA. Initial trial findings were reported at the 2017...

Immunotherapy

Jedd D. Wolchok, MD, PhD, on The Future of Immunotherapy: Keynote Lecture

Solid Tumors
Immunotherapy

Preliminary Results Show Activity for Mesothelin‑Directed CAR T-Cell Therapy in Malignant Mesothelioma

A phase I clinical trial showed encouraging results with chimeric antigen receptor (CAR) T-cell therapy targeted to the mesothelin protein in patients with mesothelin-associated malignant pleural solid tumors—primarily, malignant mesothelioma—that had progressed following standard platinum-based...

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Colonoscopy Polyp Detection Rates and Endoscopist Characteristics

Previous research has suggested that specific factors about the doctor performing colonoscopy—for example, a gastroenterologist vs a surgeon, female vs male—were associated with different rates of detection of precancerous polyps. However, a Cleveland Clinic–led research team...