Dasatinib/Letrozole Drug Combination Delays Disease Progression in Hormone Receptor–Positive, HER2-Negative Metastatic Breast Cancer
Adding dasatinib (Sprycel) to a standard antihormone therapy, letrozole, doubled the time before disease progressed for women with hormone receptor–positive, HER2-negative metastatic breast cancer, according to results of a phase II clinical trial presented at the 2013 San Antonio Breast Cancer Symposium (Abstract S3-07).
Dasatinib, which inhibits the activity of the Src protein, is approved by the U.S. Food and Drug Administration for the treatment of chronic myeloid leukemia.
“Patients with metastatic breast cancer desperately need new treatment options that can lengthen and improve the quality of their lives,” said Devchand Paul, DO, PhD, a breast oncologist at US Oncology and Rocky Mountain Cancer Centers in Denver. “Because several studies have linked high levels of Src activity to breast cancer metastasis to the bone, we wanted to see whether combining letrozole and dasatinib as first-line treatment for metastatic breast cancer would improve the clinical-benefit rate and progression-free survival compared with letrozole alone," he said.
“We are encouraged to see that the combination doubled progression-free survival time,” he added. “But this was a small study, and we really need a biomarker to measure Src activity in breast tumors, so that we can better determine which patients will be most likely to benefit from the addition of dasatinib to letrozole.”
Study Details
Dr. Paul and colleagues enrolled 120 postmenopausal women with locally recurrent or metastatic hormone receptor–positive, HER2-negative breast cancer in the phase II clinical trial. They randomly assigned 63 participants to letrozole and 57 to letrozole plus dasatinib. The primary aim of the study was to determine whether adding dasatinib to letrozole increased the clinical-benefit rate (the number of patients who had a complete response, plus the number who had a partial response, plus the number who had stable disease for 6 or more months).
The researchers found that adding dasatinib to letrozole did not increase the clinical-benefit rate compared with letrozole alone (64% vs 61%). When a second measure of the study’s outcome was analyzed, the combination therapy was shown to dramatically improve progression-free survival. Progression-free survival for patients receiving dasatinib and letrozole was 20.1 months compared with 9.9 months for letrozole alone.
Patients receiving dasatinib plus letrozole did experience additional side effects, but none were considered severe adverse events, according to Dr. Paul, and most patients tolerated the full dose of dasatinib.
Biomarker for Src Activity Needed
“Although these data suggest that adding dasatinib to letrozole improves progression-free survival for postmenopausal women with hormone receptor–positive, HER2-negative metastatic breast cancer, we would like to find a biomarker for Src activity in the breast before conducting larger clinical studies of this drug combination,” said Dr. Paul.
This study was supported by funds from Bristol-Myers Squibb. Dr. Paul reported no potential conflicts of interest.
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