AATS 2016: Stage IIIA NSCLC Survival Rates Improved When Care Included Four Specific Quality Measures
Current guidelines from the National Comprehensive Cancer Network (NCCN) and American College of Chest Physicians (ACCP) recommend that operable patients with clinical stage IIIA non–small cell lung cancer (NSCLC) should receive induction chemotherapy (with or without concurrent radiotherapy) followed by resection if there is no apparent progression of disease. While four quality measures have been identified as associated with improved overall survival, until now it has been unclear to what extent patients are actually receiving each of these measures as part of their care. A presentation by Samson et al at the 96th American Association for Thoracic Surgery (AATS) Annual Meeting clearly demonstrates that survival rates increase as more quality measures are incorporated into patient care—but only 13% of eligible patients actually received all four measures.
Analysis of data from the National Cancer Data Base (NCDB) demonstrated that the survival rates of patients with stage IIIA NSCLC who underwent surgery increased more than three-fold for those who received four quality measures as part of their care. The study, presented by Pamela Samson MD, MPHS, of Washington University in St. Louis, also shows a wide variability in compliance with quality measures, with only 12.8% of almost 8,000 eligible patients having received all four interventions. The study highlights the importance of implementing these recommended steps into actual practice.
“Compliance with national recommendations regarding induction therapy and approach to surgical resection are crucial to optimizing long-term survival outcomes in clinical stage IIIA NSCLC,” explained Dr. Samson.
Study Findings
The investigators analyzed NCDB data to identify clinical stage IIIA NSCLC patients who underwent surgical resection from 2006–2011. The four quality measures investigated were neoadjuvant multiagent chemotherapy, lobar resection, sampling of at least 10 lymph nodes, and R0 resection.
Data clearly indicated the benefit of including more quality measures into patient care. Overall median survival, which began at 12.7 months for patients who did not receive any of the measures, increased to 25.0 months for those receiving one measure; 31.4 months for those receiving two measures; 36.6 months for those receiving three measures; and 43.5 months for receiving all four measures.
Between 2006 and 2010, 19% (10,304) of 54,069 patients with clinical stage IIIA NSCLC underwent surgical resection. Among these patients, the most frequently missed measure was receipt of neoadjuvant multiagent chemotherapy (only approximately 30%), followed by sampling of at least 10 lymph nodes taken for only 40% of patients. Eighty-four percent received a lobectomy or greater resection and 87% obtained negative surgical margins. Despite the proven benefits of receiving all four quality measures as part of patient care, the investigators found that only 12.8% of individuals with clinical stage IIIA NSCLC received all four interventions.
When the investigators looked at what variables were associated with receiving the most complete care, they found private insurance or Medicare status, higher education, and receiving care at an academic cancer or high-volume surgical center were associated with increased likelihood of receiving all four quality measures. Those who received fewer interventions tended to be older, non-Caucasian, and with multiple comorbidities.
“This analysis demonstrated that the majority of clinical stage IIIA NSCLC patients are not receiving multiagent induction chemotherapy prior to resection. This is surprising, given the fact that the majority of patients in this study (80%) presented with clinical N2 disease,” commented Dr. Samson. Noting that median overall survival was greater for patients who received multiagent induction chemotherapy compared to those who did not, Dr. Samson emphasized, “This underscores the need for evaluation of the clinical stage IIIA NSCLC patient by a multidisciplinary group.”
The authors noted, “While this study demonstrated that achieving these selected quality measures, both individually and collectively, was associated with improved overall survival, it also revealed that patient, institutional, and tumor factors independently influence whether patients receive these key quality measures.”
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
