Older People With Faster Decline in Memory and Thinking Skills May Have Lower Risk of Cancer Death
Older people who are starting to have memory and thinking problems, but do not yet have dementia, may have a lower risk of dying from cancer than people who have no memory and thinking problems, according to a study by Benito-León et al published online in Neurology.
“Studies have shown that people with Alzheimer’s disease are less likely to develop cancer, but we don’t know the reason for that link,” said study author Julián Benito-León, MD, PhD, of University Hospital “12 of October” in Madrid. “One possibility is that cancer is underdiagnosed in people with dementia, possibly because they are less likely to mention their symptoms or because caregivers and doctors are focused on the problems caused by dementia. The current study helps us discount that theory.”
Study Details
The study involved 2,627 people age 65 and older in Spain who did not have dementia at the start of the study. They took tests of memory and thinking skills at the start of the study and again 3 years later, and were followed for an average of almost 13 years. The participants were divided into three groups: those whose scores on the thinking tests were declining the fastest, those whose scores improved on the tests, and those in the middle.
During the study, 1,003 of the participants died, including 339 deaths (34%) among those with the fastest decline in thinking skills and 664 deaths (66%) among those in the other two groups. A total of 21% of those in the group with the fastest decline died of cancer, according to their death certificates, compared to 29% of those in the other two groups (hazard ratio [HR] = 0.75, P = .04).
People in the fastest-declining group were still 30% less likely to die of cancer when the results were adjusted to control for factors such as smoking, diabetes, and heart disease among others (HR = 0.70, P = .01).
“We need to understand better the relationship between a disease that causes abnormal cell death and one that causes abnormal cell growth,” Dr. Benito-León said. “With the increasing number of people with both dementia and cancer, understanding this association could help us better understand and treat both diseases.”
Dr. Benito-Leónis the corresponding author for the Neurology article.
The study was supported by the Spanish Health Research Agency, the Spanish Office of Science and Technology, the National Institutes of Health and the European Commission.
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
