Anne-Lise Børresen-Dale, DSc, Professor at the University of Oslo and Head of the Department of Genetics at the University Hospital Radiumhospitalet in Oslo, Norway, was honored with the 8th Annual American Association for Cancer Research (AACR) Distinguished Lectureship in Breast Cancer Research at the 2015 San Antonio Breast Cancer Symposium.
The AACR Distinguished Lectureship in Breast Cancer Research was established to recognize outstanding science that has inspired or has the potential to inspire new perspectives on the etiology, diagnosis, treatment, or prevention of breast cancer.
Pioneer in Genetics
Dr. Børresen-Dale is among the leading geneticists in research on molecular biology of breast cancer, and her group was among the pioneers in expression profiling of breast carcinomas in collaboration with groups at Stanford University, demonstrating that breast cancer can be divided into distinct subgroups with differences in molecular profiles and in overall and relapse-free survival. Her achievements are seminal for understanding breast cancer evolution and have had an enormous impact on our view of the complexity of breast cancer.
Dr. Børresen-Dale’s current research projects focus on exploring the systems biology of breast cancer using high-dimensional data in integrated approaches. These studies aim to identify the genotypes and gene-expression profiles that contribute to elevated cancer risk, radiation sensitivity, tumor aggressiveness, and therapy resistance. The goal of this work is to follow the linear time course of tumor progression to dissect the molecular mechanisms triggered at each stage of disease. ■