First Comprehensive Pediatric Hematology/Oncology Initiative Launched in Africa


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Through public-private partnerships with the governments of Botswana, Uganda, and Malawi, His Excellency the President Lieutenant General Dr. Seretse Khama Ian Khama, of the Republic of Botswana; the Honorable Minister Dorcas Makgato, of the Ministry of Health and Wellness; the Bristol-Myers Squibb Foundation; Texas Children’s Cancer and Hematology Centers (TXCH), and Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children’s Hospital (BIPAI) have announced a $100 million initiative to create an innovative pediatric hematology/oncology treatment network in southern and eastern Africa. The comprehensive initiative called Global HOPE (Hematology-Oncology Pediatric Excellence) will build long-term capacity to treat and dramatically improve the prognosis of thousands of children with cancer and blood disorders in southern and eastern Africa.


With only five pediatric oncologists currently in the countries of Botswana, Malawi, and Uganda combined, there are simply not enough expert doctors to treat all the children diagnosed with blood disorders and cancer.
— David G. Poplack, MD

In the United States, 80% of children with cancer survive. In sub-Saharan Africa, the overwhelming majority of pediatric patients with cancer do not survive. The mortality rate is estimated to be as high as 90%, meaning thousands of children die of cancer across Africa each year. This is in large part due to an inadequate health-care infrastructure and a significant lack of expert physicians and other health-care workers trained to treat children with cancer. The most common types of childhood cancers are hematologic cancers, including leukemia and lymphoma.

Global HOPE will partner with local governments and ministries of health to build medical capacity to diagnose and treat pediatric blood disorders and cancer in Botswana, Malawi, and Uganda. The initiative will also create significant clinical, educational, and research capabilities. Doctors, nurses, and ancillary professionals will be recruited from around the world to provide training to local health-care professionals and begin treating children with blood disorders and cancer immediately.

The Bristol-Myers Squibb Foundation is committing $50 million over 5 years to fund the training of health-care providers, as well as a clinical infrastructure and operations. BIPAI will raise an additional $50 million for the initiative.

The various governments will each play an important role in developing the pediatric hematology/oncology network, assisting with the training, technical assistance, logistics, and resources to support Global HOPE. The Global HOPE initiative will train an estimated 4,800 health-care professionals from Botswana, Uganda, Malawi, and other African countries, including doctors and nurses specializing in pediatric hematology/oncology and social workers. The program estimates that over 5,000 children will receive care in the first 5 years.

Collaboration Needed

“This project is building on a solid foundation for pediatric cancer treatment in Botswana that began with pediatric oncologists from Texas Children’s Cancer and Hematology Centers,” said Dr. Seretse Khama Ian Khama. “The Global HOPE program will bring to Botswana the latest biomedical technologies and the potential to work with local institutions such as the Botswana Innovation Hub and the University of Botswana to quickly increase the survival of children with cancer and life-threatening blood disorders in Botswana and the region.”

Dr. Seretse Khama Ian Khama

Dr. Seretse Khama Ian Khama

Dorcas Makgato

Dorcas Makgato

Giovanni Caforio, MD

Giovanni Caforio, MD

“We are eager to get started on this critical initiative to help children with blood disorders and cancer. Working with our partners and drawing on our expertise of building sustainable health systems in underserved countries, we will help make a significant difference in the outcomes for children while creating a blueprint for other countries to follow,” said Giovanni Caforio, MD, Chairman of the Board of the Bristol-Myers Squibb Foundation and Chief Executive Officer, Bristol-Myers Squibb Company.

“With only five pediatric oncologists currently in the countries of Botswana, Malawi, and Uganda combined, there are simply not enough expert doctors to treat all the children diagnosed with blood disorders and cancer. We believe in these countries there are more than 11,000 new cases annually of pediatric cancer and 40,000 new cases of serious, life-threatening blood disorders, such as sickle cell disease and hemophilia. Because of these staggering numbers, more health-care providers with special expertise are urgently needed,” said David G. Poplack, MD, Director of Texas Children’s Cancer and Hematology Centers and Professor of Pediatric Oncology at Baylor College of Medicine.

The Global HOPE initiative will be modeled on the work of the Bristol-Myers Squibb Foundation; BIPAI; and the governments of Botswana, Uganda, and Malawi, which created the largest pediatric HIV treatment network in the world, leveraging existing experience, infrastructure, and public/private partnerships created through the initiative. Since 2003, the Bristol-Myers Squibb Foundation and BIPAI have trained 52,000 health-care professionals and currently provide care for nearly 300,000 children with HIV and their families in sub-Saharan Africa, lowering the mortality rate for these children to 1.2%. ■



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