CHAARTED and GETUG-15 Studies


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Christopher J. Sweeney, MBBS

Gwenaelle Gravis, MD

At the 2014 ASCO Annual Meeting, the phase III E3805 (CHAARTED) trial presented at the Plenary Session showed that the addition of docetaxel to standard hormone therapy extended survival by more than 1 year in men with newly diagnosed, hormone-sensitive prostate cancer.1 The survival benefit of docetaxel was mainly driven by men with extensive metastatic disease.

Lead author Christopher J. Sweeney, MBBS, of the Lank Center of Genitourinary Oncology at the Dana-Farber Cancer Institute in Boston, said: “The data from STAMPEDE and CHAARTED identify a strategy that prolongs survival in newly diagnosed metastatic prostate cancer. The benefit is substantial and warrants this being adopted as a new standard treatment for men who have high-extent disease and are able to tolerate chemotherapy.”

The study randomized 790 men to androgen-deprivation therapy alone vs androgen deprivation plus six cycles of docetaxel. Median overall survival was significantly superior in the docetaxel-containing arm: 57.6 months vs 44 months (P = .0003), for a 39% reduction in the risk of death. In men with extensive disease, median overall survival was 49.2 months for the combination vs 32.2 months for androgen deprivation alone (P < .0006), for a 40% reduction in the risk of death.

At the 2015 Genitourinary Cancers Symposium, lead author Gwenaelle Gravis, MD, reported an updated overall survival analysis of GETUG-15.2 The updated analysis, with a follow-up of 82.9 months, showed a median overall survival of 60.9 months for androgen-deprivation therapy plus docetaxel vs 46.5 months for androgen-deprivation therapy alone, which was not statistically significant. ■

Disclosure: Dr. Gravis is on the board of and receives travel support from Sanofi-Aventis. Dr. Sweeney is a compensated consultant for Astellas, AstraZeneca, Bayer, BIND Therapeutics, Genentech, Janssen, and Sanofi.

References

1. Sweeney C, et al: 2014 ASCO Annual Meeting. Abstract LBA2.

2. Gravis G, et al: 2015 ASCO Annual Meeting. Abstract 140.


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