Clinical Trials Actively Recruiting Geriatric Oncology Patients


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THE INFORMATION contained in this Clinical Trials Resource Guide includes actively recruiting clinical studies focused on geriatric oncology. These studies highlight psychological interventions, managing cancer symptoms, the surgical process, fall prevention, and making treatment decisions; as well as platelet recovery in hematologic malignancies and endocrine therapy in breast cancer. All of the studies are listed on the National Institutes of Health website at ClinicalTrials.gov. 

INTERVENTIONAL 

Study Title: Managing Anxiety From Cancer: A Pilot Randomized Controlled Trial of a Psychological Intervention for Anxiety in Older Adults With Cancer and Their Caregivers 

Study Type: Interventional/randomized/parallel assignment 

Study Sponsor and Collaborators: Weill Medical College of Cornell University, National Institute on Aging, American Federation for Aging Research 

Purpose: To examine the preliminary efficacy of a telephone-administered cognitive behavioral therapy intervention for anxiety in older adults (65 years and older) with cancer and their primary informal caregiver 

Primary Outcome Measures: Anxiety subscale of the Hospital Anxiety and Depression Scale; Hamilton Anxiety Rating Scale [time frame: baseline (1–2 weeks after enrollment) and follow-up (7–9 weeks after baseline)] 

Principal Investigator: Kelly Trevino, PhD, Weill Cornell Medicine; contact Chrystal Marte, BA, (646) 962-6179, chm2075@ med.cornell.edu 

ClinicalTrials.gov Identifier: NCT03168971

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Study Title: Promoting Cancer Symptom Management in Older Adults 

Study Type: Interventional/randomized/parallel assignment 

Study Sponsor and Collaborators: University of Central Florida, University of South Florida, Orlando Health Inc. 

Purpose: To estimate the effect size of a technology-based intervention for older adults with cancer for nausea and vomiting 

Primary Outcome Measures: Symptom severity change, cognitive representation change, and health-related quality of life change over time [time frame: weeks 1, 4, 7, 10]; self-management behaviors over time, resource use over time [time frame: weeks 4, 7, 10] 

Principal Investigator: Victoria Loerzel, PhD, University of Central Florida; (407) 823-0762, victoria.loerzel@ucf.edu 

ClinicalTrials.gov Identifier: NCT03143829

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Study Title: Perioperative Geriatrics Intervention for Older Cancer Patients Undergoing Surgical Resection 

Study Type: Interventional/randomized/parallel assignment 

Study Sponsor and Collaborators: Massachusetts General Hospital, National Comprehensive Cancer Network 

Purpose: To addresses the challenge of managing the unique perioperative needs of older cancer patients undergoing surgical resection in pancreatic, esophageal, and gastric cancers 

Primary Outcome Measures: Hospital length of stay [time frame: 2 years] 

Principal Investigator: Ryan Nipp, MD, Massachusetts General Hospital; (617) 724-4000 

ClinicalTrials.gov Identifier: NCT02810652 

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Study Title: A Breast Cancer Treatment Decision Aid for Women Aged 70 and Older 

Study Sponsor and Collaborators: Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center 

Purpose: To evaluate a decision aid to help women aged 70 and older decide on treatment for breast cancer 

Primary Outcome Measures: Change in decisional conflict scale at 1 week [time frame: baseline, 1 week] 

Principal Investigator: Mara Schonberg, MD, MPH, Beth Israel Deaconess Medical Center; (617) 754-1414 

ClinicalTrials.gov Identifier: NCT02823262 

PHASE I 

Study Title: Adaptation of the Stepping On Fall Prevention Program for Older Adults Receiving Cancer Therapy 

Study Type: Phase I/interventional/single-group assignment 

Study Sponsor and Collaborators: Washington University School of Medicine 

Purpose: To adapt the effective group education–based fall-prevention intervention Stepping On, tailored to cancer patients 

Primary Outcome Measures: Percent of participants who completed the 7 educational sessions [time frame: completion of all participants in the Pilot Wave groups (approximately 85 weeks)] 

Principal Investigator: Tanya Wildes, MD, MSCI, Washington University School of Medicine; (314) 454-8681, twildes@wustl.edu 

ClinicalTrials.gov Identifier: NCT02737839 

PHASE II 

Study Title: A Single-Arm, Phase II Study of Eltrombopag to Enhance Platelet Count Recovery in Elderly Patients With Acute Myeloid Leukemia Undergoing Remission Induction Therapy 

Study Type: Phase II/interventional/single-group assignment 

Study Sponsor and Collaborators: Case Comprehensive Cancer Center, National Cancer Institute 

Purpose: To evaluate how well eltrombopag olamine works in improving the recovery of platelet counts in older patients with acute myeloid leukemia undergoing induction chemotherapy 

Primary Outcome Measures: Patients with a median platelet count ≥ 50,000/mL [time frame: day 24 of treatment] 

Principal Investigator: Sudipto Mukherjee, MD, PhD, MPH, Case Comprehensive Cancer Center; (216) 445-9353, sekerem@ccf.org 

ClinicalTrials.gov Identifier: NCT02071901 

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Study Title: Endocrine Treatment Alone as Primary Treatment for Elderly Patients With Estrogen Receptor–Positive Operable Breast Cancer and a Low Recurrence Score 

Study Type: Phase II/interventional/single-group assignment 

Study Sponsor and Collaborators: Washington University School of Medicine 

Purpose: To evaluate whether endocrine therapy alone provides adequate local/systemic control of breast cancer in women 70 or older with estrogen receptor–positive breast cancer and low Ki67 scores 

Primary Outcome Measures: Response rate [time frame: 6 months] 

Principal Investigator: Rebecca L. Aft, MD, PhD, Washington University School of Medicine; (314) 747-0063, aftr@wustl.edu 

ClinicalTrials.gov Identifier: NCT02476786 

Editor’s Note: The clinical trials presented here do not represent all the trials listed on ClinicalTrials.gov. For the complete list, go to ClinicalTrials.gov.


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