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Expert Point of View: Geraldine M. Jacobson, MD



Although it is widely used, we didn’t have the data to support this practice. Now we have the data and it is clear that using a boost in ductal carcinoma in situ improves local control. This study should be practice-changing.
— Geraldine M. Jacobson, MD

Geraldine M. Jacobson, MD, of West Virginia University, Morgantown, commented on the study by Moran et al at a press conference held during the American Society of Radiation Oncology (ASTRO) meeting, where the data were presented.

“To date evidence has been lacking for a radiation boost following whole-breast radiation therapy for ductal carcinoma in situ. This study shows a lower recurrence rate in the same breast when a radiation boost is added to breast-conserving therapy with surgery and whole-breast radiation therapy. The study is notable for its size and long-term follow-up,” Dr. Jacobson said.

“Using a radiation boost is common and standard of care in many centers for ductal carcinoma in situ as well as for invasive cancer. Although it is widely used, we didn’t have the data to support this practice for ductal carcinoma in situ. Now we have the data, and it is clear that using a boost in ductal carcinoma in situ improves local control. This study should be practice-changing,” Dr. Jacobson said. ■

Disclosure: Dr. Jacobson reported no potential conflicts of interest.


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A radiation boost to the local tumor bed following treatment with breast-conserving therapy (ie, local excision followed by whole-breast radiation therapy) improves local control for patients with ductal carcinoma in situ, according to a study of pooled data from 10 academic centers,1 presented at...


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