Researchers Awarded NCI Grants to Address ‘Provocative Questions’


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Two scientists are among the first recipients of grants geared to answer “Provocative Questions” in cancer research, a new project funded by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).  Cynthia Sears, MD, and Peter Searson, PhD, both of Johns Hopkins, will receive more than $500,000 combined in the first of 5 years of funding.

The federally funded “Provocative Questions” project will distribute more than $22 million this year among 57 grant recipients nationwide.  Each grant aims to provide answers to one of 24 questions, solicited from the research community, that address neglected or unsolved areas of cancer research.

Dr. Sears and Dr. Searson’s projects were chosen by a specially-designed peer-review process from among more than 700 applications submitted by scientists.

Infection and Cancer

Dr. Sears will receive $236,480 in the first year of funding to examine how and why certain cancers may be caused by infections.  An infectious disease expert, Dr. Sears has previously linked some colon cancers to common diarrheal bacteria, and her research will further explore how these and other microbes may cause colon cancer.  Dr. Sears, a professor of medicine and oncology at Johns Hopkins, says these discoveries may help physicians detect earlier those at risk for colon cancer and prevent it more effectively.

Metastasis

With $316,513 in first-year funding, Dr. Searson will develop a new method to study metastasis. He proposes a device with an artificial blood vessel and other cellular components to study the spread of cancer. The “lab-on-a-chip” approach could replicate processes that occur in metastasis and provide a testing ground for experiments with a method easily reproduced by scientists. Dr. Searson is the Joseph R. and Lynn C. Reynolds Professor of Materials Science and Engineering and directs the Johns Hopkins Institute for NanoBioTechnology.

For more about NCI’s Provocative Questions, visit http://provocativequestions.nci.nih.gov/ ■



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