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Researchers Observe an Increased Risk of Cancer in People with History of Nonmelanoma Skin Cancer

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Key Points

  • Researchers analyzed data from two large United States cohort studies: the Health Professionals Follow-up Study and the Nurses' Health Study.
  • A history of nonmelanoma skin cancer was significantly associated with a 15% higher risk of other primary cancers in men, and a 26% higher risk of other primary cancers in women.
  • Because the study was observational, results should be interpreted cautiously and are insufficient evidence to alter current clinical recommendations.

A prospective study by researchers at Brigham and Women's Hospital observed an association between risk of second primary cancer and history of nonmelanoma skin cancer in white men and women.

The researchers found that people with a history of nonmelanoma skin cancer had a modestly increased risk of getting cancer in the future, specifically breast and lung cancer in women and melanoma in both men and women. Nonmelanoma skin cancer, which includes basal cell and squamous cell carcinoma, is the most common form of cancer in the United States.

The study was published on April 23, 2013 in PLOS Medicine.

Two Large Cohort Studies

The researchers analyzed data from two large United States cohort studies: the Health Professionals Follow-up Study and the Nurses' Health Study. The researchers followed 46,237 men from June 1986 to June 2008 in the Health Professionals Follow-up Study, and 107,339 women from June 1984 to June 2008 in the Nurses' Health Study. The researchers identified 36,102 new cases of nonmelanoma skin cancer and 29,447 new cases of other primary cancers.

A history of nonmelanoma skin cancer was significantly associated with a 15% higher risk of other primary cancers in men, and a 26% higher risk of other primary cancers in women. When melanoma was excluded from this analysis, the rates changed slightly, with a history of nonmelanoma skin cancer associated with an 11% higher risk of other primary cancers in men, and a 20% higher risk of other primary cancers in women. 

After using statistical models to correct for multiple comparisons, looking at individual cancer sites, the researchers found that a history of nonmelanoma skin cancer was significantly linked to an increased risk of breast and lung cancer in women, and an increased risk of melanoma in both men and women.

Continued Investigation Needed

According to the researchers, these findings should be interpreted cautiously.

"Because our study was observational, these results should be interpreted cautiously and are insufficient evidence to alter current clinical recommendations," said Jiali Han, PhD, Channing Division of Network Medicine, Department of Medicine and Department of Dermatology, Brigham and Women's Hospital. "Nevertheless, these data support a need for continued investigation of the potential mechanisms underlying this relationship."

This research was supported by the National Institutes of Health (CA87969 and CA055075).

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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