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By DAN L. LONGO, MD, MACP, AND JAMES O. ARMITAGE, MD, FASCO  / October 2025

Considerations on Cancer Drug Development

In the 1940s, the first drugs proven to cause objective responses in human cancers were developed. Mechlorethamine was discovered as a possible treatment of lymphoid cancers after autopsies on military personnel exposed to mustard gas found destruction of lymphatic tissue and bone marrow....