2012 San Antonio Breast Cancer Symposium

breast cancer

Radiation Therapy for Patients with Invasive Breast Cancer: 3 Weeks Proves as Effective as 5 Weeks

Ten-year follow-up of the two-part UK Standardisation of Breast Radiotherapy Trials (START) supported the 5-year findings, demonstrating that a 3-week course of adjuvant radiation therapy is equivalen...

breast cancer

Adjuvant Tamoxifen for Women with ER-positive Breast Cancer: 10 Years Superior to 5 Years

Five years of tamoxifen has long been considered the standard of care as adjuvant therapy for women with estrogen receptor–positive breast cancer. However, extending tamoxifen treatment for 10 years r...

breast cancer

Primary Endpoint Not Met for Eribulin vs Capecitabine in Breast Cancer 

While a global phase III trial failed to meet its primary endpoint in showing an overall or progression-free survival benefit for eribulin (Halavan) in metastatic breast cancer, a trend toward greater...

breast cancer

Somatic HER2 Mutations That Drive Cancer Found in HER2-negative Breast Cancer 

A proportion of patients with breast cancer whose tumors test HER2-negative for gene amplification on fluorescence in situ hybridization or immunohistochemistry harbor HER2 mutations that are amenable...

breast cancer

Key Pathways Identified in Triple-negative Breast Cancer 

Five key biologic pathways have become evident in triple-negative breast cancer tumors, and these pathways may be targetable with agents that are currently available or in development, results from an...

breast cancer

Research Roundup from San Antonio: New Data on Triple-negative, HER2-positive, Local, and Advanced Breast Cancer 

The 2012 San Antonio Breast Cancer Symposium featured more than 2,500 abstracts and lectures, including timely research in the field and discussions for scientists and clinicians alike. In addition to...

breast cancer

For Lobular Carcinoma, Letrozole Works Better Than Tamoxifen  

In the treatment of postmenopausal estrogen receptor–positive women with lobular carcinoma, letrozole appears to have a greater benefit than tamoxifen, according to an analysis of this subset of patie...

breast cancer

Novel Oral Agent plus Letrozole Improves Progression-free Survival in ER-positive Advanced Breast Cancer 

The combination of letrozole plus a novel oral inhibitor of cyclin-dependent kinase 4/6 called PD 0332991 achieved an unprecedented improvement in progression-free survival among women with advanced e...

breast cancer
leukemia

Chemotherapy for Breast Cancer Carries a Small, but Concerning, Risk for Leukemia 

The risk for developing a secondary malignancy after chemotherapy for breast cancer is very small, but it is statistically significantly higher than for the general population, a review of the Nationa...

breast cancer

Pathologic Complete Response Yields Long-term Benefits in Meta-analysis  

Breast cancer patients who achieve a pathologic complete response to neoadjuvant therapy have more favorable outcomes than those who do not, according to a meta-analysis of neoadjuvant trials presente...

breast cancer

Dose-dense Chemotherapy in Breast Cancer: Epirubicin-based Regimens Studied in German and UK Trials

In the treatment of early breast cancer, dose-dense regimens (given every 2 weeks) have proven superior to conventionally dosed chemotherapy (given every 3 weeks), but data on long-term survival are l...

breast cancer

Final 'Joint Analysis' Confirms Life-saving Benefit of Trastuzumab in Patients with HER2-positive Early Breast Cancer

In the final planned joint analysis of overall survival from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-31 and North Central Cancer Treatment Group (NCCTG) N9831 trials, the add...

breast cancer

Black Women Less Likely to Get Sentinel Lymph Node Biopsy and More Likely to Have Lymphedema on Axillary Lymph Node Dissection 

Although sentinel lymph node biopsy is the recommended method for axillary staging of node-negative breast cancer, racial disparities in access to care were found in a study presented at the 2012 San ...

breast cancer

Role of Sentinel Node Surgery Explored in Node-positive Breast Cancer 

Sentinel lymph node surgery performed after neoadjuvant chemotherapy in women presenting with node-positive disease could spare many patients with breast cancer needless axillary lymph node dissection...

breast cancer

21-gene Recurrence Score Does Not Predict Paclitaxel Benefit  

The 21-gene recurrence score significantly predicted the risk of recurrence and death in node-positive, estrogen receptor–positive patients treated with adjuvant chemoendocrine therapy, but it did not...

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