In the final analysis of the phase III POTOMAC trial reported in The Lancet, De Santis et al found that the addition of durvalumab to bacillus Calmette-Guérin (BCG) induction and maintenance improved disease-free survival in patients with high-risk non–muscle-invasive bladder cancer (NMIBC) who underwent transurethral resection of bladder tumor (TURBT).
In 2018, the federal government expanded the coverage duration of short-term limited-duration (STLD) health plans from 3 months to less than 12 months, with the option to renew for a total duration of up to 36 months. Some states imposed more stringent regulations than those federally imposed or banned the sale of these STLD plans, while other states did not have any additional regulations.
The U.S. Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER) and Center for Biologics Evaluation and Research (CBER) have collaborated with the European Medicines Agency (EMA) to develop a set of 10 guiding principles for good uses of artificial intelligence (AI) in drug development. The principles are aimed at industry members and product developers who are using AI to facilitate and accelerate drug/biological product development.
In a prespecified interim analysis of a phase III trial (University of Texas MD Anderson Cancer Center Clinical Trial Consortium trial) reported in The Lancet, Frank et al found that intensity-modulated proton therapy (IMPT) was noninferior to standard intensity-modulated photon radiation therapy (IMRT) in progression-free survival among patients with stage III or IV oropharyngeal cancer.
A machine-learning model has calculated country-specific cancer mortality-to-incidence ratios and evaluated the factors that contribute the most to each country's survival gaps. Additionally, the artificial intelligence (AI) tool mapped out actions each country could take to improve cancer outcomes. A report explaining the establishment of the machine learning framework and its country-specific findings was published in Annals of Oncology.
Editor’s note: On November 22, 2025—the 62nd anniversary of her grandfather President John F. Kennedy’s assassination—Tatiana Celia Kennedy Schlossberg published an essay in The New Yorker detailing her diagnosis of acute myeloid leukemia with chromosome 3 inversion, a rare and aggressive subtype...
Repeated methodological flaws in published research result in misinformation that may cause eligible patients to forego or not be offered lung cancer screening, according to a joint publication from the Society of Thoracic Surgeons (STS), American Society for Radiation Oncology (ASTRO), and...
A new ASCO guideline provides recommendations on managing cancer during pregnancy, addressing a range of topics from the selection and timing of diagnostic testing and therapeutic interventions to delivery planning and ethical and legal considerations.1 The guideline aims to inform evidence-based...
In patients with advanced HER2-positive gastroesophageal adenocarcinoma, treatment with the bispecific antibody zanidatamab-hrii and chemotherapy, with or without the PD-1 inhibitor tislelizumab-jsgr, reduced the risk of disease progression or death by 35% over trastuzumab plus chemotherapy in the...
The results of a recent survey showed that patients largely support the use of artificial intelligence (AI) to aid radiologists in reading mammograms. The findings, which were published in Breast Cancer Research and Treatment, also indicated acceptance varied in association with factors such as...
Deb Schrag, MD, MPH, FASCO On December 19, 2025, ASCO announced its members had elected Deb Schrag, MD, MPH, FASCO,as President for the 2027–2028 term. Dr. Schrag will begin her term as President-Elect upon the conclusion of the 2026 ASCO Annual Meeting. Dr. Schrag, a gastrointestinal medical...
In a phase II trial (RedirecTT-1) reported in The New England Journal of Medicine, Kumar et al found that the combination of talquetamab (anti–G protein–coupled receptor family C group 5 member D) and teclistamab (anti–B-cell maturation antigen) produced high response rates in patients with...