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Lung Cancer

First-Line Nivolumab Alone and Combined With Platinum-Based Chemotherapy in Advanced NSCLC

The phase I CheckMate 012 study examined the effects of nivolumab monotherapy and nivolumab combined with platinum-based doublets as first-line treatments in patients with...

Issues in Oncology

ASCO and AACI Initiative to Reduce Administrative and Regulatory Burden in Cancer Clinical Trials

As reported in the Journal of Clinical OncologyJulie M. Vose, MD, MBA, FASCO, of the University of Nebraska Medical Center, Omaha, and colleagues have provided...

Head and Neck Cancer

Testosterone Therapy May Be Cardioprotective in Patients Undergoing Chemotherapy

The anabolic hormone testosterone may lessen the early adverse cardiovascular effects of chemotherapy and chemoradiation for advanced or recurrent cancer, according to a randomized...


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CNS Cancers

Martin J. Van Den Bent, MD, PhD, on Anaplastic Glioma: Results from the CATNON Trial

President Obama Names Margaret Spitz, MPH, to National Cancer Advisory Board

Margaret Spitz, MPH, Professor in the National Cancer Institute (NCI)-designated Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine, has been appointed by President Barack Obama as a member of the National Cancer Advisory Board (NCAB).

A renowned expert in molecular...

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Nonwhite Organ Transplant Recipients Also at Heightened Risk for Skin Cancer

A new study from Drexel University College of Medicine suggests all organ transplant recipients, regardless of race, should receive routine, total-body screenings for skin cancer.

Out of 259 nonwhite transplant recipients who were evaluated in the study, 19 skin cancer lesions were identified in...

Palliative Care
Issues in Oncology

Charles D. Blanke, MD, on Oregon’s Death With Dignity Act

Lung Cancer

Phase III Study Launches in Patients With Small Cell Lung Cancer

On August 2, 2016, PharmaMar announced the start of a pivotal phase III ATLANTIS study evaluating the efficacy and safety of ­lurbinectedin (PM1183), a novel synthetic tetrahydroisoquinoline that targets active transcription. The study is evaluating lurbinectedin combined with doxorubicin vs...

Breast Cancer

Nipple-Sparing Mastectomy Shown to Be Safe—and Increasingly Preferred

Prophylactic mastectomy that preserves a woman’s nipple is oncologically safe in patients with deleterious BRCA mutations, according to the largest study yet to evaluate this approach in this high-risk population. “In more than 500 risk-reducing nipple-sparing mastectomies in 348 deleterious...

High-Calcium, Low-Lactose Diet May Reduce Risk of Ovarian Cancer in African American Women

Research from Rutgers Cancer Institute of New Jersey and and other U.S. health and academic institutions shows a diet high in calcium and low in lactose may reduce the risk of ovarian cancer in African American women. The work, published by Qin et al in the British Journal of Cancer, also found sun ...

Lymphoma

James O. Armitage, MD, on Improving Lymphoma Treatment

Breast Cancer

New SSO, ASTRO, ASCO Joint Ductal Carcinoma in Situ Consensus Guideline Could Curb Unnecessary Breast Surgery and Reduce Health-System Costs

Three leading national cancer organizations have issued a consensus guideline for physicians treating women who have ductal carcinoma in situ treated with breast-conserving surgery with whole-breast irradiation. The new guideline has the potential to save many women from unnecessary surgeries,...

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Comparison of Second-Line Treatments in Advanced Pancreatic Cancer After Gemcitabine-Based Chemotherapy

In the Canadian phase III PANCREOX trial reported in the Journal of Clinical Oncology, Gill et al found no benefit of modified FOLFOX6 (infusional fluorouracil [5-FU], leucovorin, and oxaliplatin) vs infusional 5-FU/leucovorin as second-line treatment in patients with advanced pancreatic cancer who ...


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