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March 10, 2017   (View All Issues)

Eric D. Tetzlaff, MHS, PA-C, Receives National Recognition as AAPA Distinguished Fellow

Eric D. Tetzlaff, MHS, PA-C, a physician assistant at Fox Chase Cancer Center, has been recognized as a Distinguished Fellow of the American Academy of Physician Assistants (AAPA). He practices clinical care for patients with gastrointestinal cancers and...

Breast Cancer

Cancer Has Aged Me

The news that I had breast cancer came at an especially difficult time in my life and was quite shocking to hear. My father had died of lung cancer just 1 month before my diagnosis, and I was still grieving his death when I suddenly had to confront my own mortality. In...

Multiple Myeloma

FDA Approves Lenalidomide as Maintenance Therapy for Patients With Multiple Myeloma Following Autologous Stem Cell Transplant

On February 22, the U.S. Food and Drug Administration (FDA) expanded the existing indication for lenalidomide (Revlimid) 10-mg capsules to include use for patients with multiple myeloma as maintenance therapy following autologous hematopoietic stem cell transplant.

Clinical Trial Findings

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Issues in Oncology

Potential Biomarker of Recurrent Venous Thromboembolism in Patients Receiving Anticoagulants

In a biomarker analysis of the CATCH trial reported in the Journal of Clinical Oncology, Alok A. Khorana, MD, of the Cleveland Clinic, and colleagues found that elevated circulating tissue factor levels were associated with an increased risk of recurrent venous thromboembolism in cancer patients on ...

Colorectal Cancer

Germline Cancer Susceptibility Mutations in Early-Onset Colorectal Cancer

In a study reported in JAMA Oncology, Pearlman et al found that 16% of patients with early-onset colorectal cancer had germline cancer susceptibility mutations, with a wide array of such mutations being identified. Heather Hampel, MS, CGC, of The Ohio State University Comprehensive Cancer Center,...

Colorectal Cancer

Addition of Cetuximab to Chemoradiotherapy for Anal Carcinoma

In a phase II trial (Eastern Cooperative Oncology Group–American College of Radiology Imaging Network Cancer Research Group E3205) reported in the Journal of Clinical Oncology, Garg et al found that the addition of cetuximab (Erbitux) to definitive chemoradiotherapy appeared to reduce the rates of...

Bladder Cancer

Pembrolizumab in Locally Advanced or Metastatic Urothelial Cancer

As reported by Elizabeth R. Plimack, MD, of Fox Chase Cancer Center, Temple Health, and colleagues in The Lancet Oncology, pembrolizumab (Keytruda) has shown activity in patients in the locally advanced or metastatic urothelial carcinoma cohort included in the phase Ib KEYNOTE-012 trial.

In the...

2017 Oncology Meetings

MARCH

ESMO Symposium on Signaling Pathways in Cancer 2017
March 17-18 • Barcelona, Spain
For more information: 
http://esmo.org/Conferences/Signalling-Pathways-2017

17th Multidisciplinary Management of Cancers: A Case-Based Approach
March 17-19 • Napa, California
For more information:

Gynecologic Cancers

Cervical Cancer Mortality Is Higher and Racial Disparity Wider Than Previously Reported

Cervical cancer mortality rates were significantly higher, particularly among black women, when national data were corrected to exclude women who have had hysterectomies. For black women, the cervical cancer mortality rate rose from 5.7 to 10.1 per 100,000 when corrected for...

Gynecologic Cancers

Expect Questions About the Cervical Cancer Mortality Study

A widely reported study found that cervical cancer mortality was higher and the racial disparity between black and white women greater than previously reported.1 The study omitted from the mortality estimates those women who had undergone hysterectomies, usually involving removal of the cervix.

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Scripps Florida Collaboration Awarded $3.3 Million to Develop Next-Generation Breast Cancer Therapies

A pair of scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded up to $3.3 million from the National Cancer Institute of the National Institutes of Health (NIH) to create the next generation of breast...

Colorectal Cancer

Clinical Trials Actively Recruiting Patients With Colorectal Cancer

Phase I

Study Title: A Pilot Study of SGI-110 in Combination With an Allogeneic Colon Cancer Cell Vaccine and Cyclophosphamide in Metastatic Colorectal Cancer as Maintenance Therapy

Study Type: Phase I/interventional/parallel assignment

Study Sponsor and Collaborators: Sidney Kimmel...

Hematologic Malignancies

Pacritinib Reduces Spleen Volume in Myelofibrosis

The investigational drug pacritinib met the primary endpoint of the phase III PERSIST-2 trial in high-risk patients with myelofibrosis and thrombocytopenia. Treatment with the Janus kinase (JAK)1/2 inhibitor pacritinib achieved a significant reduction in spleen volume compared with best available...

Expert Point of View: Selina Luger, MD, Stephanie Lee, MD, and Gabriela Hobbs, MD

Speaking at the 2016 American Society of Hematology (ASH) Annual Meeting & Exposition, before the hold on pacritinib was lifted (in January 2017), Selina Luger, MD, of the University of Pennsylvania, Philadelphia, commented, “I think the U.S. Food and Drug...

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